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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016019304> ?p ?o ?g. }

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• W2016019304 abstract "Mad2 is a component of the spindle checkpoint, which delays the onset of anaphase until all chromosomes are attached to the spindle. Mad2 formed a complex with Slp1, a WD (tryptophan–aspartic acid)–repeat protein essential for the onset of anaphase. When the physical interaction between the two proteins was disrupted, the spindle checkpoint was no longer functional. Post-anaphase events such as chromosome decondensation and the next round of DNA replication were not delayed even when the spindle assembly was incomplete. This relief of dependence appears to be a result of deregulation of ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex." @default.
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• W2016019304 date "1998-02-13" @default.
• W2016019304 modified "2023-10-18" @default.
• W2016019304 title "Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint" @default.
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• W2016019304 doi "https://doi.org/10.1126/science.279.5353.1045" @default.
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