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- W2016020065 abstract "The nucleotide sequence coding for the structural proteins and nonstructural protein P2A has been determined for a foot-and-mouth disease virus (FMDV) isolated in Africa. This virus, serotypically designated SAT3 (South African Territories type 3), shows about 60% homology at the nucleotide level to prototype viruses from the O, A and C serotypes of FMDV. The highest region of variability was shown in structural protein VP1, presumably a consequence of its position on the surface of the virus and its exposure to selection pressure by neutralising antibody. Within this region amino acids (aa) 141-160, which have been shown to represent an immunodominant region in other FMDV serotypes, showed hypervariability as well as the insertion of 5 or 9 additional aa relative to the O1 and C1 serotypes, respectively. In contrast, the sequence of nonstructural protein P2A was completely conserved indicating a probable important role in virus replication." @default.
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- W2016020065 date "1989-02-01" @default.
- W2016020065 modified "2023-09-27" @default.
- W2016020065 title "The nucleotide sequence of the structural-protein-coding region of foot-and-mouth disease virus serotype SAT3" @default.
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- W2016020065 doi "https://doi.org/10.1016/0378-1119(89)90268-0" @default.
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