Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016020339> ?p ?o ?g. }
- W2016020339 endingPage "4668" @default.
- W2016020339 startingPage "4655" @default.
- W2016020339 abstract "The study of molybdocene dichloride and related metallocenes has been dominated by their remarkable catalytic properties in organic synthesis and polymer chemistry. Interest in the aqueous, bioorganometallic chemistry of metallocene dihalides has stemmed from the potent antitumor properties of titanocene dichloride, including results from human clinical trials. This review will summarize key results reported in the last decade on the biological chemistry of molybdocene dichloride. The effect of concentration, pH and ionic strength on the rates of hydrolysis of both the cyclopentadienyl and halide ligands have established that the positively charged monoaquated species Cp2Mo(OH)(OH2)+, in equilibrium with the dipositively charged dimer Cp2Mo(μ-OH)2MoCp2, is present under physiological conditions. Systematic studies of the coordination chemistry of Cp2MoCl2 with nucleobases, nucleotides, single-stranded and double-stranded oligonucleotides, and calf-thymus DNA have shown that while simultaneous phosphate(O) and heterocyclic(N) adducts are formed with nucleotides, negligible interaction with DNA occurs under physiological conditions. In contrast, Cp2MoCl2 forms strong, non-labile complexes with deprotonated thiols in amino acids. Molybdocene dichloride is able to catalyse the hydrolysis of activated phosphate esters under physiological conditions, but hydrolysis of unactivated phosphodiesters is only significant at pH 4. Limited antitumor activity results, inhibition studies with protein kinase C and topoisomerase II, structure–activity and cell-uptake studies have provided some insight into possible mechanisms of antitumor action." @default.
- W2016020339 created "2016-06-24" @default.
- W2016020339 creator A5041073658 @default.
- W2016020339 creator A5059883521 @default.
- W2016020339 date "2004-12-01" @default.
- W2016020339 modified "2023-10-12" @default.
- W2016020339 title "Bioorganometallic chemistry of molybdocene dichloride" @default.
- W2016020339 cites W1504792186 @default.
- W2016020339 cites W1556983269 @default.
- W2016020339 cites W1964339338 @default.
- W2016020339 cites W1964686168 @default.
- W2016020339 cites W1967716470 @default.
- W2016020339 cites W1969608306 @default.
- W2016020339 cites W1972769427 @default.
- W2016020339 cites W1972777289 @default.
- W2016020339 cites W1973591492 @default.
- W2016020339 cites W1974075450 @default.
- W2016020339 cites W1976070579 @default.
- W2016020339 cites W1978612964 @default.
- W2016020339 cites W1980602295 @default.
- W2016020339 cites W1980637183 @default.
- W2016020339 cites W1981519760 @default.
- W2016020339 cites W1981608558 @default.
- W2016020339 cites W1982200369 @default.
- W2016020339 cites W1988006807 @default.
- W2016020339 cites W1990991016 @default.
- W2016020339 cites W1991588605 @default.
- W2016020339 cites W1992673178 @default.
- W2016020339 cites W1992689192 @default.
- W2016020339 cites W1994386521 @default.
- W2016020339 cites W2012952812 @default.
- W2016020339 cites W2016041661 @default.
- W2016020339 cites W2017030176 @default.
- W2016020339 cites W2020843484 @default.
- W2016020339 cites W2024056557 @default.
- W2016020339 cites W2028058466 @default.
- W2016020339 cites W2032458072 @default.
- W2016020339 cites W2032974886 @default.
- W2016020339 cites W2033210527 @default.
- W2016020339 cites W2036389903 @default.
- W2016020339 cites W2039102028 @default.
- W2016020339 cites W2040529066 @default.
- W2016020339 cites W2041363678 @default.
- W2016020339 cites W2045108068 @default.
- W2016020339 cites W2050139724 @default.
- W2016020339 cites W2050545246 @default.
- W2016020339 cites W2051299003 @default.
- W2016020339 cites W2052597254 @default.
- W2016020339 cites W2055423055 @default.
- W2016020339 cites W2061104651 @default.
- W2016020339 cites W2061623771 @default.
- W2016020339 cites W2064108777 @default.
- W2016020339 cites W2065539197 @default.
- W2016020339 cites W2067392488 @default.
- W2016020339 cites W2068193883 @default.
- W2016020339 cites W2070896353 @default.
- W2016020339 cites W2075753407 @default.
- W2016020339 cites W2076572569 @default.
- W2016020339 cites W2079496128 @default.
- W2016020339 cites W2081269241 @default.
- W2016020339 cites W2082339176 @default.
- W2016020339 cites W2083433470 @default.
- W2016020339 cites W2084854198 @default.
- W2016020339 cites W2085137152 @default.
- W2016020339 cites W2088982227 @default.
- W2016020339 cites W2092889823 @default.
- W2016020339 cites W2092973670 @default.
- W2016020339 cites W2093282189 @default.
- W2016020339 cites W2104969843 @default.
- W2016020339 cites W2107509757 @default.
- W2016020339 cites W2123374199 @default.
- W2016020339 cites W2125013139 @default.
- W2016020339 cites W2136006702 @default.
- W2016020339 cites W2136412106 @default.
- W2016020339 cites W2147831973 @default.
- W2016020339 cites W2155153351 @default.
- W2016020339 cites W2155942338 @default.
- W2016020339 cites W2241061912 @default.
- W2016020339 cites W2288093942 @default.
- W2016020339 cites W2314230250 @default.
- W2016020339 cites W2484892587 @default.
- W2016020339 cites W2943284274 @default.
- W2016020339 cites W2949845980 @default.
- W2016020339 cites W2951336203 @default.
- W2016020339 cites W3004576110 @default.
- W2016020339 cites W4236530034 @default.
- W2016020339 cites W4321429130 @default.
- W2016020339 cites W2160112818 @default.
- W2016020339 doi "https://doi.org/10.1016/j.jorganchem.2004.08.014" @default.
- W2016020339 hasPublicationYear "2004" @default.
- W2016020339 type Work @default.
- W2016020339 sameAs 2016020339 @default.
- W2016020339 citedByCount "63" @default.
- W2016020339 countsByYear W20160203392012 @default.
- W2016020339 countsByYear W20160203392013 @default.
- W2016020339 countsByYear W20160203392014 @default.
- W2016020339 countsByYear W20160203392015 @default.
- W2016020339 countsByYear W20160203392016 @default.