Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016020580> ?p ?o ?g. }
- W2016020580 endingPage "714" @default.
- W2016020580 startingPage "707" @default.
- W2016020580 abstract "The efficacy and safety of ursodeoxycholic acid for the treatment of primary sclerosing cholangitis were evaluated in a prospective, randomized, double-blind, placebo-controlled trial. Fourteen patients with primary sclerosing cholangitis documented by cholestatic serum enzyme pattern, liver histological appearance and endoscopic retrograde cholangiography were included in the trial. Six patients received ursodeoxycholic acid (13 to 15 mg/kg body wt/day), and eight patients received placebo. Two patients had to be withdrawn from the study, one because of UDCA-related diarrhea and the other because of worsening of the disease during placebo treatment. Patients in the ursodeoxycholic acid group improved significantly during 1 yr of treatment with respect to serum levels of bilirubin (median = − 50%), alkaline phosphatase (median = − 67%), γ-glutamyltransferase (median = − 53%), AST (median = − 54%) and ALT (median = − 36%) compared with the placebo group, but not with respect to serum levels of hydrophobic bile acids. During ursodeoxycholic acid treatment, histopathological features also improved significantly, as evaluated by multiparametric score. Expression of human leukocyte antigen class I molecules appeared to be markedly reduced on liver cells after ursodeoxycholic acid treatment. We conclude that ursodeoxycholic acid is beneficial in reducing disease activity in patients with primary sclerosing cholangitis (HEPATOLOGY 1992;16:707–714.)" @default.
- W2016020580 created "2016-06-24" @default.
- W2016020580 creator A5004014900 @default.
- W2016020580 creator A5013436002 @default.
- W2016020580 creator A5018461629 @default.
- W2016020580 creator A5025623640 @default.
- W2016020580 creator A5031739149 @default.
- W2016020580 creator A5035424488 @default.
- W2016020580 creator A5036524512 @default.
- W2016020580 creator A5057294605 @default.
- W2016020580 creator A5058633927 @default.
- W2016020580 creator A5083074963 @default.
- W2016020580 date "1992-09-01" @default.
- W2016020580 modified "2023-10-03" @default.
- W2016020580 title "Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial" @default.
- W2016020580 cites W1655637944 @default.
- W2016020580 cites W1868512026 @default.
- W2016020580 cites W1963971641 @default.
- W2016020580 cites W1965455197 @default.
- W2016020580 cites W1965984516 @default.
- W2016020580 cites W1976350579 @default.
- W2016020580 cites W1978726559 @default.
- W2016020580 cites W1989687473 @default.
- W2016020580 cites W1993497306 @default.
- W2016020580 cites W1996463505 @default.
- W2016020580 cites W2003832074 @default.
- W2016020580 cites W2011544949 @default.
- W2016020580 cites W2013605037 @default.
- W2016020580 cites W2019185937 @default.
- W2016020580 cites W2026255173 @default.
- W2016020580 cites W2045122920 @default.
- W2016020580 cites W2055967995 @default.
- W2016020580 cites W2066051973 @default.
- W2016020580 cites W2073922746 @default.
- W2016020580 cites W2100345391 @default.
- W2016020580 cites W2136003508 @default.
- W2016020580 cites W2189502830 @default.
- W2016020580 cites W2249424390 @default.
- W2016020580 cites W2316970164 @default.
- W2016020580 cites W65249248 @default.
- W2016020580 doi "https://doi.org/10.1002/hep.1840160315" @default.
- W2016020580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1505913" @default.
- W2016020580 hasPublicationYear "1992" @default.
- W2016020580 type Work @default.
- W2016020580 sameAs 2016020580 @default.
- W2016020580 citedByCount "413" @default.
- W2016020580 countsByYear W20160205802012 @default.
- W2016020580 countsByYear W20160205802013 @default.
- W2016020580 countsByYear W20160205802014 @default.
- W2016020580 countsByYear W20160205802015 @default.
- W2016020580 countsByYear W20160205802016 @default.
- W2016020580 countsByYear W20160205802017 @default.
- W2016020580 countsByYear W20160205802018 @default.
- W2016020580 countsByYear W20160205802019 @default.
- W2016020580 countsByYear W20160205802020 @default.
- W2016020580 countsByYear W20160205802021 @default.
- W2016020580 countsByYear W20160205802022 @default.
- W2016020580 countsByYear W20160205802023 @default.
- W2016020580 crossrefType "journal-article" @default.
- W2016020580 hasAuthorship W2016020580A5004014900 @default.
- W2016020580 hasAuthorship W2016020580A5013436002 @default.
- W2016020580 hasAuthorship W2016020580A5018461629 @default.
- W2016020580 hasAuthorship W2016020580A5025623640 @default.
- W2016020580 hasAuthorship W2016020580A5031739149 @default.
- W2016020580 hasAuthorship W2016020580A5035424488 @default.
- W2016020580 hasAuthorship W2016020580A5036524512 @default.
- W2016020580 hasAuthorship W2016020580A5057294605 @default.
- W2016020580 hasAuthorship W2016020580A5058633927 @default.
- W2016020580 hasAuthorship W2016020580A5083074963 @default.
- W2016020580 hasBestOaLocation W20160205801 @default.
- W2016020580 hasConcept C126322002 @default.
- W2016020580 hasConcept C142724271 @default.
- W2016020580 hasConcept C204787440 @default.
- W2016020580 hasConcept C27081682 @default.
- W2016020580 hasConcept C2779134260 @default.
- W2016020580 hasConcept C2779399885 @default.
- W2016020580 hasConcept C2780615123 @default.
- W2016020580 hasConcept C2780965833 @default.
- W2016020580 hasConcept C41260117 @default.
- W2016020580 hasConcept C71924100 @default.
- W2016020580 hasConcept C90924648 @default.
- W2016020580 hasConceptScore W2016020580C126322002 @default.
- W2016020580 hasConceptScore W2016020580C142724271 @default.
- W2016020580 hasConceptScore W2016020580C204787440 @default.
- W2016020580 hasConceptScore W2016020580C27081682 @default.
- W2016020580 hasConceptScore W2016020580C2779134260 @default.
- W2016020580 hasConceptScore W2016020580C2779399885 @default.
- W2016020580 hasConceptScore W2016020580C2780615123 @default.
- W2016020580 hasConceptScore W2016020580C2780965833 @default.
- W2016020580 hasConceptScore W2016020580C41260117 @default.
- W2016020580 hasConceptScore W2016020580C71924100 @default.
- W2016020580 hasConceptScore W2016020580C90924648 @default.
- W2016020580 hasIssue "3" @default.
- W2016020580 hasLocation W20160205801 @default.
- W2016020580 hasLocation W20160205802 @default.
- W2016020580 hasOpenAccess W2016020580 @default.
- W2016020580 hasPrimaryLocation W20160205801 @default.
- W2016020580 hasRelatedWork W1500136501 @default.