Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016020917> ?p ?o ?g. }
- W2016020917 endingPage "970" @default.
- W2016020917 startingPage "955" @default.
- W2016020917 abstract "Accumulated studies support the concept that angiotensin peptides, ANG II, ANG III, and ANG IV act as neurotransmitters or neuromodulators in specific neuronal pathways in the brain stem, the hypothalamus, and the forebrain. They have been implicated in the regulation of several physiological processes, particularly in excitable brain structures that express high concentration of their receptors. With the help of pharmacological approaches it was shown that angiotensin peptides appear to be anticonvulsant in a variety of experimental seizure models. Thus, ANG II increases the threshold for pentylenetetrazol (PTZ)-, bicuculline-and picrotoxin-induced seizures in mice. It also attenuates the intensity of clonic seizures evoked by PTZ and 3-mercaptopropionic acid and is effective in the maximal electroshock test. Furthermore, ANG II, ANG III, and ANG IV protect against the clonic convulsions in the PTZ kindling model of epilepsy in mice. From the accumulated results it could be assumed that the angiotensin peptides appear to realize their effects acting directly on their receptors (AT1, AT2 and AT4) and through close interaction with different neurotransmitter/neuromodulator systems as dopamine (DA)-, γ-aminobutyric acid (GABA)-and adenosine. This may contribute to a new potential use of angiotensin drugs either alone or in combination with other neuroprotective agents acting through the above mentioned systems, thus providing a more rational strategy for the treatment of neurodegenerative disorders such as epilepsy." @default.
- W2016020917 created "2016-06-24" @default.
- W2016020917 creator A5043759723 @default.
- W2016020917 creator A5054977145 @default.
- W2016020917 date "2005-01-01" @default.
- W2016020917 modified "2023-09-24" @default.
- W2016020917 title "Angiotensin peptides modulatory system: how is it implicated in the control of seizure susceptibility?" @default.
- W2016020917 cites W1451468118 @default.
- W2016020917 cites W1498299392 @default.
- W2016020917 cites W1527240164 @default.
- W2016020917 cites W1547520663 @default.
- W2016020917 cites W180111337 @default.
- W2016020917 cites W1924604258 @default.
- W2016020917 cites W1964431010 @default.
- W2016020917 cites W1965570459 @default.
- W2016020917 cites W1965796042 @default.
- W2016020917 cites W1967396852 @default.
- W2016020917 cites W1967561584 @default.
- W2016020917 cites W1971123881 @default.
- W2016020917 cites W1971877978 @default.
- W2016020917 cites W1976760386 @default.
- W2016020917 cites W1978012759 @default.
- W2016020917 cites W1978919937 @default.
- W2016020917 cites W1979219161 @default.
- W2016020917 cites W1979794715 @default.
- W2016020917 cites W1980243405 @default.
- W2016020917 cites W1980768697 @default.
- W2016020917 cites W1987935978 @default.
- W2016020917 cites W1989043544 @default.
- W2016020917 cites W1990152014 @default.
- W2016020917 cites W1992934690 @default.
- W2016020917 cites W1994092047 @default.
- W2016020917 cites W1994459346 @default.
- W2016020917 cites W1998052464 @default.
- W2016020917 cites W2003365988 @default.
- W2016020917 cites W2004459039 @default.
- W2016020917 cites W2005807525 @default.
- W2016020917 cites W2010544476 @default.
- W2016020917 cites W2015853734 @default.
- W2016020917 cites W2018207510 @default.
- W2016020917 cites W2018953916 @default.
- W2016020917 cites W2020501220 @default.
- W2016020917 cites W2021806512 @default.
- W2016020917 cites W2022366666 @default.
- W2016020917 cites W2028685283 @default.
- W2016020917 cites W2029851860 @default.
- W2016020917 cites W2030261100 @default.
- W2016020917 cites W2030294368 @default.
- W2016020917 cites W2034301751 @default.
- W2016020917 cites W2039784260 @default.
- W2016020917 cites W2044518616 @default.
- W2016020917 cites W2044856070 @default.
- W2016020917 cites W2045263244 @default.
- W2016020917 cites W2047427670 @default.
- W2016020917 cites W2054633565 @default.
- W2016020917 cites W2055165476 @default.
- W2016020917 cites W2055853933 @default.
- W2016020917 cites W2057201665 @default.
- W2016020917 cites W2057497438 @default.
- W2016020917 cites W2059458854 @default.
- W2016020917 cites W2061691710 @default.
- W2016020917 cites W2061898251 @default.
- W2016020917 cites W2064072008 @default.
- W2016020917 cites W2064630989 @default.
- W2016020917 cites W2064810764 @default.
- W2016020917 cites W2065236378 @default.
- W2016020917 cites W2069202057 @default.
- W2016020917 cites W2069623880 @default.
- W2016020917 cites W2069817913 @default.
- W2016020917 cites W2072705096 @default.
- W2016020917 cites W2074553874 @default.
- W2016020917 cites W2075728188 @default.
- W2016020917 cites W2078182584 @default.
- W2016020917 cites W2078679216 @default.
- W2016020917 cites W2080951265 @default.
- W2016020917 cites W2082641194 @default.
- W2016020917 cites W2090122225 @default.
- W2016020917 cites W2092692364 @default.
- W2016020917 cites W2095364526 @default.
- W2016020917 cites W2098355288 @default.
- W2016020917 cites W2101782576 @default.
- W2016020917 cites W2104900442 @default.
- W2016020917 cites W2119995804 @default.
- W2016020917 cites W2142459107 @default.
- W2016020917 cites W2152210748 @default.
- W2016020917 cites W2164533579 @default.
- W2016020917 cites W2170758304 @default.
- W2016020917 cites W2325437079 @default.
- W2016020917 cites W2414953932 @default.
- W2016020917 cites W4253721610 @default.
- W2016020917 doi "https://doi.org/10.1016/j.lfs.2004.10.012" @default.
- W2016020917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15607326" @default.
- W2016020917 hasPublicationYear "2005" @default.
- W2016020917 type Work @default.
- W2016020917 sameAs 2016020917 @default.
- W2016020917 citedByCount "49" @default.
- W2016020917 countsByYear W20160209172012 @default.
- W2016020917 countsByYear W20160209172013 @default.