FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016024450> ?p ?o ?g. }

• W2016024450 endingPage "e3215" @default.
• W2016024450 startingPage "e3215" @default.
• W2016024450 abstract "Background Numerous studies were performed to illuminate mechanisms of tumorigenesis and metastases from gene expression profiles of Head and Neck Squamous Cell Carcinoma (HNSCC). The objective of this review is to conduct a network-based meta-analysis to identify the underlying biological signatures of the HNSCC transcriptome. Methods and Findings We included 63 HNSCC transcriptomic studies into three specific categories of comparisons: Pre, premalignant lesions v.s. normal; TvN, primary tumors v.s. normal; and Meta, metastatic or invasive v.s. primary tumors. Reported genes extracted from the literature were systematically analyzed. Participation of differential gene activities across three progressive stages deciphered the evolving nature of HNSCC. In total, 1442 genes were verified, i.e. reported at least twice, with ECM1, EMP1, CXCL10 and POSTN shown to be highly reported across all three stages. Knowledge-based networks of the HNSCC transcriptome were constructed, demonstrating integrin signaling and antigen presentation pathways as highly enriched. Notably, functional estimates derived from topological characteristics of integrin signaling networks identified such important genes as ITGA3 and ITGA5, which were supported by findings of invasiveness in vitro [1]. Moreover, we computed genome-wide probabilities of reporting differential gene activities for the Pre, TvN, and Meta stages, respectively. Results highlighted chromosomal regions of 6p21, 19p13 and 19q13, where genomic alterations were shown to be correlated with the nodal status of HNSCC [2]. Conclusions By means of a systems-biology approach via network-based meta-analyses, we provided a deeper insight into the evolving nature of the HNSCC transcriptome. Enriched canonical signaling pathways, hot-spots of transcriptional profiles across the genome, as well as topologically significant genes derived from network analyses were highlighted for each of the three progressive stages, Pre, TvN, and Meta, respectively." @default.
• W2016024450 created "2016-06-24" @default.
• W2016024450 creator A5055239555 @default.
• W2016024450 creator A5061074200 @default.
• W2016024450 creator A5066656738 @default.
• W2016024450 date "2008-09-15" @default.
• W2016024450 modified "2023-10-11" @default.
• W2016024450 title "The Evolving Transcriptome of Head and Neck Squamous Cell Carcinoma: A Systematic Review" @default.
• W2016024450 cites W1977381126 @default.
• W2016024450 cites W1979141644 @default.
• W2016024450 cites W1984389010 @default.
• W2016024450 cites W1986311875 @default.
• W2016024450 cites W2000442546 @default.
• W2016024450 cites W2003918239 @default.
• W2016024450 cites W2004182185 @default.
• W2016024450 cites W2012852001 @default.
• W2016024450 cites W2017987256 @default.
• W2016024450 cites W2020830322 @default.
• W2016024450 cites W2023208820 @default.
• W2016024450 cites W2057626690 @default.
• W2016024450 cites W2062889582 @default.
• W2016024450 cites W2091119718 @default.
• W2016024450 cites W2114496328 @default.
• W2016024450 cites W2122683221 @default.
• W2016024450 cites W2136976640 @default.
• W2016024450 cites W2137082708 @default.
• W2016024450 cites W2142741765 @default.
• W2016024450 cites W2146027304 @default.
• W2016024450 cites W2159675211 @default.
• W2016024450 doi "https://doi.org/10.1371/journal.pone.0003215" @default.
• W2016024450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2533097" @default.
• W2016024450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18791647" @default.
• W2016024450 hasPublicationYear "2008" @default.
• W2016024450 type Work @default.
• W2016024450 sameAs 2016024450 @default.
• W2016024450 citedByCount "55" @default.
• W2016024450 countsByYear W20160244502012 @default.
• W2016024450 countsByYear W20160244502013 @default.
• W2016024450 countsByYear W20160244502014 @default.
• W2016024450 countsByYear W20160244502015 @default.
• W2016024450 countsByYear W20160244502016 @default.
• W2016024450 countsByYear W20160244502017 @default.
• W2016024450 countsByYear W20160244502018 @default.
• W2016024450 countsByYear W20160244502020 @default.
• W2016024450 countsByYear W20160244502021 @default.
• W2016024450 countsByYear W20160244502023 @default.
• W2016024450 crossrefType "journal-article" @default.
• W2016024450 hasAuthorship W2016024450A5055239555 @default.
• W2016024450 hasAuthorship W2016024450A5061074200 @default.
• W2016024450 hasAuthorship W2016024450A5066656738 @default.
• W2016024450 hasBestOaLocation W20160244501 @default.
• W2016024450 hasConcept C104317684 @default.
• W2016024450 hasConcept C121608353 @default.
• W2016024450 hasConcept C150194340 @default.
• W2016024450 hasConcept C162317418 @default.
• W2016024450 hasConcept C2776530083 @default.
• W2016024450 hasConcept C2776833033 @default.
• W2016024450 hasConcept C502942594 @default.
• W2016024450 hasConcept C54355233 @default.
• W2016024450 hasConcept C555283112 @default.
• W2016024450 hasConcept C60644358 @default.
• W2016024450 hasConcept C70721500 @default.
• W2016024450 hasConcept C86803240 @default.
• W2016024450 hasConceptScore W2016024450C104317684 @default.
• W2016024450 hasConceptScore W2016024450C121608353 @default.
• W2016024450 hasConceptScore W2016024450C150194340 @default.
• W2016024450 hasConceptScore W2016024450C162317418 @default.
• W2016024450 hasConceptScore W2016024450C2776530083 @default.
• W2016024450 hasConceptScore W2016024450C2776833033 @default.
• W2016024450 hasConceptScore W2016024450C502942594 @default.
• W2016024450 hasConceptScore W2016024450C54355233 @default.
• W2016024450 hasConceptScore W2016024450C555283112 @default.
• W2016024450 hasConceptScore W2016024450C60644358 @default.
• W2016024450 hasConceptScore W2016024450C70721500 @default.
• W2016024450 hasConceptScore W2016024450C86803240 @default.
• W2016024450 hasIssue "9" @default.
• W2016024450 hasLocation W20160244501 @default.
• W2016024450 hasLocation W20160244502 @default.
• W2016024450 hasLocation W20160244503 @default.
• W2016024450 hasLocation W20160244504 @default.
• W2016024450 hasLocation W20160244505 @default.
• W2016024450 hasLocation W20160244506 @default.
• W2016024450 hasOpenAccess W2016024450 @default.
• W2016024450 hasPrimaryLocation W20160244501 @default.
• W2016024450 hasRelatedWork W2028462563 @default.
• W2016024450 hasRelatedWork W2104762330 @default.
• W2016024450 hasRelatedWork W2399513595 @default.
• W2016024450 hasRelatedWork W2523545060 @default.
• W2016024450 hasRelatedWork W2982720988 @default.
• W2016024450 hasRelatedWork W3150324899 @default.
• W2016024450 hasRelatedWork W3155641129 @default.
• W2016024450 hasRelatedWork W4229998356 @default.
• W2016024450 hasRelatedWork W4311517665 @default.
• W2016024450 hasRelatedWork W4379374180 @default.
• W2016024450 hasVolume "3" @default.
• W2016024450 isParatext "false" @default.
• W2016024450 isRetracted "false" @default.
• W2016024450 magId "2016024450" @default.

• next