FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016027026> ?p ?o ?g. }

• W2016027026 endingPage "820" @default.
• W2016027026 startingPage "811" @default.
• W2016027026 abstract "Nanoparticle lipid matrices are being recently explored for controlled drug delivery applications. The degree of crystallinity of the lipid matrix governs drug loading capacity and release rates. Current methods of preparing nanoparticle lipid matrices, like high-pressure homogenization and solvent-emulsification evaporation, offer limited or poor control over lipid crystallinity. The present work explores a droplet-phase aerosol synthesis method to prepare nanoparticle aerosol lipid matrices (NALM). Control of evaporation rate was used to achieve control over crystallinity of NALM. NALM were synthesized in an aerosol reactor using precursor solutions of stearic acid in organic solvents with widely different vapour pressures, resulting in different rates of evaporation. Mean mobility diameter, measured using a scanning mobility particle sizer (SMPS), ranged from 94–127 nm, with a unimodal distribution and geometric standard deviation of 1.7–1.9. Aerodynamic diameters measured using gravimetric analysis of samples collected in a micro-orifice cascade impactor, ranged from 423–608 nm. Relatively higher peak intensities and peak areas in X-ray diffractograms, and higher melting enthalpies in the differential scanning calorimetry (DSC) thermograms were obtained for NALM synthesized under lower evaporation rates, using lower vapour pressure solvents, similar to that of bulk stearic acid. In contrast, NALM synthesized at higher evaporation rates, using higher vapour pressure solvents consistently showed a lower degree of crystallinity, evidenced by blunt X-ray diffraction peaks and lower melting enthalpies in DSC analysis. These results suggest the formation of non-equilibrium crystal structures within NALM, under the influence of faster evaporation rates, leading to a lower degree of crystallinity. The work demonstrates proof of concept of droplet-phase aerosol synthesis for preparing nanoparticle lipid matrices and for achieving control over their crystallinity." @default.
• W2016027026 created "2016-06-24" @default.
• W2016027026 creator A5039920902 @default.
• W2016027026 creator A5065322765 @default.
• W2016027026 date "2011-07-01" @default.
• W2016027026 modified "2023-10-14" @default.
• W2016027026 title "Droplet-Phase Synthesis of Nanoparticle Aerosol Lipid Matrices with Controlled Properties" @default.
• W2016027026 cites W1579046626 @default.
• W2016027026 cites W196564504 @default.
• W2016027026 cites W1976444992 @default.
• W2016027026 cites W1976677427 @default.
• W2016027026 cites W1977543574 @default.
• W2016027026 cites W1977755432 @default.
• W2016027026 cites W1982560226 @default.
• W2016027026 cites W1986161411 @default.
• W2016027026 cites W1994660012 @default.
• W2016027026 cites W1995350290 @default.
• W2016027026 cites W2009692390 @default.
• W2016027026 cites W2011920500 @default.
• W2016027026 cites W2012406121 @default.
• W2016027026 cites W2020882358 @default.
• W2016027026 cites W2025155370 @default.
• W2016027026 cites W2026546128 @default.
• W2016027026 cites W2028330536 @default.
• W2016027026 cites W2031088474 @default.
• W2016027026 cites W2033380744 @default.
• W2016027026 cites W2033752561 @default.
• W2016027026 cites W2034082246 @default.
• W2016027026 cites W2038504778 @default.
• W2016027026 cites W2044072446 @default.
• W2016027026 cites W2048724968 @default.
• W2016027026 cites W2050199502 @default.
• W2016027026 cites W2054189154 @default.
• W2016027026 cites W2062194933 @default.
• W2016027026 cites W2062334879 @default.
• W2016027026 cites W2066412524 @default.
• W2016027026 cites W2069572791 @default.
• W2016027026 cites W2073667348 @default.
• W2016027026 cites W2074037814 @default.
• W2016027026 cites W2075948283 @default.
• W2016027026 cites W2084005730 @default.
• W2016027026 cites W2085901859 @default.
• W2016027026 cites W2086319321 @default.
• W2016027026 cites W2086626740 @default.
• W2016027026 cites W2087577205 @default.
• W2016027026 cites W2090392987 @default.
• W2016027026 cites W2110537853 @default.
• W2016027026 cites W2111023720 @default.
• W2016027026 cites W2124701838 @default.
• W2016027026 cites W2140017935 @default.
• W2016027026 cites W4234618391 @default.
• W2016027026 cites W74968428 @default.
• W2016027026 doi "https://doi.org/10.1080/02786826.2011.565089" @default.
• W2016027026 hasPublicationYear "2011" @default.
• W2016027026 type Work @default.
• W2016027026 sameAs 2016027026 @default.
• W2016027026 citedByCount "11" @default.
• W2016027026 countsByYear W20160270262012 @default.
• W2016027026 countsByYear W20160270262013 @default.
• W2016027026 countsByYear W20160270262015 @default.
• W2016027026 countsByYear W20160270262016 @default.
• W2016027026 countsByYear W20160270262017 @default.
• W2016027026 countsByYear W20160270262022 @default.
• W2016027026 crossrefType "journal-article" @default.
• W2016027026 hasAuthorship W2016027026A5039920902 @default.
• W2016027026 hasAuthorship W2016027026A5065322765 @default.
• W2016027026 hasBestOaLocation W20160270261 @default.
• W2016027026 hasConcept C113196181 @default.
• W2016027026 hasConcept C121332964 @default.
• W2016027026 hasConcept C127413603 @default.
• W2016027026 hasConcept C147789679 @default.
• W2016027026 hasConcept C155672457 @default.
• W2016027026 hasConcept C159985019 @default.
• W2016027026 hasConcept C171250308 @default.
• W2016027026 hasConcept C178790620 @default.
• W2016027026 hasConcept C185592680 @default.
• W2016027026 hasConcept C187530423 @default.
• W2016027026 hasConcept C19184958 @default.
• W2016027026 hasConcept C192562407 @default.
• W2016027026 hasConcept C2779345167 @default.
• W2016027026 hasConcept C2779516699 @default.
• W2016027026 hasConcept C39519442 @default.
• W2016027026 hasConcept C42360764 @default.
• W2016027026 hasConcept C43617362 @default.
• W2016027026 hasConcept C46275449 @default.
• W2016027026 hasConcept C61441594 @default.
• W2016027026 hasConcept C97355855 @default.
• W2016027026 hasConceptScore W2016027026C113196181 @default.
• W2016027026 hasConceptScore W2016027026C121332964 @default.
• W2016027026 hasConceptScore W2016027026C127413603 @default.
• W2016027026 hasConceptScore W2016027026C147789679 @default.
• W2016027026 hasConceptScore W2016027026C155672457 @default.
• W2016027026 hasConceptScore W2016027026C159985019 @default.
• W2016027026 hasConceptScore W2016027026C171250308 @default.
• W2016027026 hasConceptScore W2016027026C178790620 @default.
• W2016027026 hasConceptScore W2016027026C185592680 @default.
• W2016027026 hasConceptScore W2016027026C187530423 @default.
• W2016027026 hasConceptScore W2016027026C19184958 @default.

• next