FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016028487> ?p ?o ?g. }

• W2016028487 endingPage "e10687" @default.
• W2016028487 startingPage "e10687" @default.
• W2016028487 abstract "Background Patients starting antiretroviral therapy (ART) for acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa have high rates of mortality in the initial weeks of treatment. We assessed the association of serum phosphate with early mortality among HIV-infected adults with severe malnutrition and/or advanced immunosuppression. Methodology/Principal Findings An observational cohort of 142 HIV-infected adults initiating ART in Lusaka, Zambia with body mass index (BMI) <16 kg/m2 or CD4+ lymphocyte count <50 cells/µL, or both, was followed prospectively during the first 12 weeks of ART. Detailed health and dietary intake history, review of systems, physical examination, serum metabolic panel including phosphate, and serum ferritin and high-sensitivity C-reactive protein (hsCRP) were monitored. The primary outcome was mortality. Baseline serum phosphate was a significant predictor of mortality; participants alive at 12 weeks had a median value of 1.30 mmol/L (interquartile range [IQR]: 1.04, 1.43), compared to 1.06 mmol/L (IQR: 0.89, 1.27) among those who died (p<0.01). Each 0.1 mmol/L increase in baseline phosphate was associated with an incremental decrease in mortality (AHR 0.83; 95% CI 0.72 to 0.95). The association was independent of other metabolic parameters and known risk factors for early ART-associated mortality in sub-Saharan Africa. While participant attrition represented a limitation, it was consistent with local program experience. Conclusions/Significance Low serum phosphate at ART initiation was an independent predictor of early mortality among HIV patients starting ART with severe malnutrition or advanced immunosuppression. This may represent a physiologic phenomenon similar to refeeding syndrome, and may lead to therapeutic interventions that could reduce mortality." @default.
• W2016028487 created "2016-06-24" @default.
• W2016028487 creator A5019896304 @default.
• W2016028487 creator A5020344819 @default.
• W2016028487 creator A5048891443 @default.
• W2016028487 creator A5050533501 @default.
• W2016028487 creator A5050621494 @default.
• W2016028487 creator A5054053039 @default.
• W2016028487 creator A5055932532 @default.
• W2016028487 creator A5056779273 @default.
• W2016028487 creator A5057523831 @default.
• W2016028487 creator A5080728144 @default.
• W2016028487 creator A5085744275 @default.
• W2016028487 creator A5086570640 @default.
• W2016028487 creator A5090564785 @default.
• W2016028487 creator A5090832540 @default.
• W2016028487 date "2010-05-18" @default.
• W2016028487 modified "2023-10-18" @default.
• W2016028487 title "Serum Phosphate Predicts Early Mortality in Adults Starting Antiretroviral Therapy in Lusaka, Zambia: A Prospective Cohort Study" @default.
• W2016028487 cites W1525831404 @default.
• W2016028487 cites W1976506287 @default.
• W2016028487 cites W1982092703 @default.
• W2016028487 cites W1992237955 @default.
• W2016028487 cites W1999408007 @default.
• W2016028487 cites W2001017566 @default.
• W2016028487 cites W2009164701 @default.
• W2016028487 cites W2019687711 @default.
• W2016028487 cites W2054862054 @default.
• W2016028487 cites W2076079580 @default.
• W2016028487 cites W2082077320 @default.
• W2016028487 cites W2093788811 @default.
• W2016028487 cites W2097586599 @default.
• W2016028487 cites W2106524327 @default.
• W2016028487 cites W2132241786 @default.
• W2016028487 cites W2133652309 @default.
• W2016028487 cites W2139894829 @default.
• W2016028487 cites W2150364761 @default.
• W2016028487 cites W2163477848 @default.
• W2016028487 cites W2187955543 @default.
• W2016028487 doi "https://doi.org/10.1371/journal.pone.0010687" @default.
• W2016028487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2872675" @default.
• W2016028487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20502700" @default.
• W2016028487 hasPublicationYear "2010" @default.
• W2016028487 type Work @default.
• W2016028487 sameAs 2016028487 @default.
• W2016028487 citedByCount "35" @default.
• W2016028487 countsByYear W20160284872012 @default.
• W2016028487 countsByYear W20160284872013 @default.
• W2016028487 countsByYear W20160284872014 @default.
• W2016028487 countsByYear W20160284872015 @default.
• W2016028487 countsByYear W20160284872016 @default.
• W2016028487 countsByYear W20160284872017 @default.
• W2016028487 countsByYear W20160284872018 @default.
• W2016028487 countsByYear W20160284872020 @default.
• W2016028487 countsByYear W20160284872021 @default.
• W2016028487 countsByYear W20160284872022 @default.
• W2016028487 crossrefType "journal-article" @default.
• W2016028487 hasAuthorship W2016028487A5019896304 @default.
• W2016028487 hasAuthorship W2016028487A5020344819 @default.
• W2016028487 hasAuthorship W2016028487A5048891443 @default.
• W2016028487 hasAuthorship W2016028487A5050533501 @default.
• W2016028487 hasAuthorship W2016028487A5050621494 @default.
• W2016028487 hasAuthorship W2016028487A5054053039 @default.
• W2016028487 hasAuthorship W2016028487A5055932532 @default.
• W2016028487 hasAuthorship W2016028487A5056779273 @default.
• W2016028487 hasAuthorship W2016028487A5057523831 @default.
• W2016028487 hasAuthorship W2016028487A5080728144 @default.
• W2016028487 hasAuthorship W2016028487A5085744275 @default.
• W2016028487 hasAuthorship W2016028487A5086570640 @default.
• W2016028487 hasAuthorship W2016028487A5090564785 @default.
• W2016028487 hasAuthorship W2016028487A5090832540 @default.
• W2016028487 hasBestOaLocation W20160284871 @default.
• W2016028487 hasConcept C119060515 @default.
• W2016028487 hasConcept C126322002 @default.
• W2016028487 hasConcept C179755657 @default.
• W2016028487 hasConcept C188816634 @default.
• W2016028487 hasConcept C201903717 @default.
• W2016028487 hasConcept C2780221984 @default.
• W2016028487 hasConcept C551997983 @default.
• W2016028487 hasConcept C71924100 @default.
• W2016028487 hasConcept C72563966 @default.
• W2016028487 hasConceptScore W2016028487C119060515 @default.
• W2016028487 hasConceptScore W2016028487C126322002 @default.
• W2016028487 hasConceptScore W2016028487C179755657 @default.
• W2016028487 hasConceptScore W2016028487C188816634 @default.
• W2016028487 hasConceptScore W2016028487C201903717 @default.
• W2016028487 hasConceptScore W2016028487C2780221984 @default.
• W2016028487 hasConceptScore W2016028487C551997983 @default.
• W2016028487 hasConceptScore W2016028487C71924100 @default.
• W2016028487 hasConceptScore W2016028487C72563966 @default.
• W2016028487 hasIssue "5" @default.
• W2016028487 hasLocation W20160284871 @default.
• W2016028487 hasLocation W20160284872 @default.
• W2016028487 hasLocation W20160284873 @default.
• W2016028487 hasLocation W20160284874 @default.
• W2016028487 hasLocation W20160284875 @default.
• W2016028487 hasOpenAccess W2016028487 @default.
• W2016028487 hasPrimaryLocation W20160284871 @default.

• next