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- W2016028521 abstract "Summary Objectives Elevated circulating androgens are risk factors for several chronic, metabolic and reproductive disorders. Metformin is an insulin‐sensitizing agent that may lower androgen levels. To evaluate the effects of metformin on endogenous androgens and SHBG levels in women, we conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs) comparing metformin with placebo or no treatment. Data source We used OVID to search MEDLINE, EMBASE and CENTRAL until March 2007. Review methods Two reviewers independently extracted data on methodological quality, participants, interventions and outcomes of interest. Our a priori primary outcome was post‐treatment measurements. In a secondary analysis, we evaluated the difference between the pre‐ and post‐treatment levels. We computed the weighted mean difference (WMD) as a measure of effect for each outcome using the DerSimonian–Laird random effects method. We used the I 2 statistic to assess heterogeneity and explored its causes in subgroup analyses of features related to participants’ characteristics and study design. Based on a regression model, we conducted sensitivity analyses by investigating the use of placebo as a predictor of effect size. Results Twenty RCTs fulfilled the inclusion criteria. Pooled WMDs in post‐treatment levels between the metformin and control group were –0·31 nmol/l (95% CI –0·65 to 0·03) for total testosterone (TT), 0·10 pmol/l (95% CI –0·89 to 1·10) for free testosterone (FT), 0·14 µmol/l (95% CI –0·34 to 0·62) for dehydroepiandrosteronesulfate (DHEAS), –0·60 nmol/l (95% CI –1·67 to 0·46) for androstenedione (AND) and 5·88 nmol/l (95% CI 2·01–9·75) for SHBG. Pooled WMDs of the pre‐ to post‐treatment differences (i.e. with adjustment for baseline hormone levels) were –0·38 (95% CI –0·51 to –0·25) for TT, –2·71 (95% CI –10·35 to 4·93) for FT, –0·50 (95% CI –0·83 to –0·16) for DHEAS, –1·39 (95% CI –2·30 to –0·49) for AND and 6·63 (95% CI 2·32–10·94) for SHBG. In subgroup analyses, features related to the administered treatment (i.e. metformin as a single agent or as part of combined regimens) partly explained the heterogeneity. Sensitivity analyses of studies using placebo showed similar results to those not using placebo. Conclusions Our systematic review and meta‐analysis provides evidence of metformin‐induced changes in circulating androgens and SHBG levels in women but the quality of evidence is not high. However, there are no data from RCTs regarding these effects in postmenopausal women or healthy premenopausal women. High‐quality RCTs are required to evaluate whether metformin has effects on surrogate markers and patient‐important outcomes in these patient groups." @default.
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- W2016028521 date "2009-03-31" @default.
- W2016028521 modified "2023-10-15" @default.
- W2016028521 title "The effects of metformin on endogenous androgens and SHBG in women: a systematic review and meta-analysis" @default.
- W2016028521 cites W1511930757 @default.
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- W2016028521 cites W1973495657 @default.
- W2016028521 cites W1977880981 @default.
- W2016028521 cites W1989901309 @default.
- W2016028521 cites W1990427206 @default.
- W2016028521 cites W2008509267 @default.
- W2016028521 cites W2014108789 @default.
- W2016028521 cites W2015778467 @default.
- W2016028521 cites W2019085069 @default.
- W2016028521 cites W2021358564 @default.
- W2016028521 cites W2021450389 @default.
- W2016028521 cites W2026898125 @default.
- W2016028521 cites W2027454738 @default.
- W2016028521 cites W2030062166 @default.
- W2016028521 cites W2034287351 @default.
- W2016028521 cites W2041591082 @default.
- W2016028521 cites W2061107904 @default.
- W2016028521 cites W2071188087 @default.
- W2016028521 cites W2079229176 @default.
- W2016028521 cites W2080973499 @default.
- W2016028521 cites W2087286513 @default.
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- W2016028521 cites W2102239047 @default.
- W2016028521 cites W2103637661 @default.
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- W2016028521 cites W2143635979 @default.
- W2016028521 cites W2149142116 @default.
- W2016028521 cites W2149222599 @default.
- W2016028521 cites W2152389407 @default.
- W2016028521 cites W2162695110 @default.
- W2016028521 cites W2163833854 @default.
- W2016028521 cites W2164376387 @default.
- W2016028521 cites W2168731503 @default.
- W2016028521 cites W2314633857 @default.
- W2016028521 cites W2324024668 @default.
- W2016028521 cites W4240940664 @default.
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- W2016028521 cites W4379436002 @default.
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- W2016028521 doi "https://doi.org/10.1111/j.1365-2265.2008.03459.x" @default.
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