FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016029316> ?p ?o ?g. }

• W2016029316 endingPage "247" @default.
• W2016029316 startingPage "240" @default.
• W2016029316 abstract "One of the claims of reductionism is that it can explain all the features of living systems by an analysis of their physico-chemical constituents. Such a claim disregards the existence in biological systems of emergent properties that do not exist in their isolated components but which allow autonomous organisms to be directively organized in a self-regulated and integrated manner. It is not possible to describe biological systems adequately without using functional language that is meaningless in the physical sciences. The description of biological functions is also an essential part of immunology and functional explanations are more useful than causal explanations also in this discipline. Since causality is not a relation between a material object and an event, the structure of an antibody cannot be the cause of its binding activity. When structure-function relationships are analysed, the search should be for correlations rather than for causal relations. Methods used to find correlations between the atomic structure of antibody binding sites and their binding activity are mostly based on mutagenesis studies. Since the effect of any mutation depends on the molecular context, it is usually very difficult to predict the effects of multiple mutations on antibody function. Our knowledge of the molecular basis of antigen-antibody recognition has led to the expectation that it may be possible to develop new vaccines using molecular design principles. Such unwarranted hopes arise because of a confusion between antigenicity and immunogenicity. Although knowledge of antibody structure is of little use in vaccine design, it may help to develop therapeutic inhibitors and antibodies effective in the passive immunotherapy of viral infection." @default.
• W2016029316 created "2016-06-24" @default.
• W2016029316 creator A5085260797 @default.
• W2016029316 date "2002-09-01" @default.
• W2016029316 modified "2023-10-13" @default.
• W2016029316 title "Reductionism and the search for structure–function relationships in antibody molecules" @default.
• W2016029316 cites W1489338305 @default.
• W2016029316 cites W1515209736 @default.
• W2016029316 cites W1528520360 @default.
• W2016029316 cites W1541909877 @default.
• W2016029316 cites W1570966565 @default.
• W2016029316 cites W1596710757 @default.
• W2016029316 cites W1966781760 @default.
• W2016029316 cites W1973144212 @default.
• W2016029316 cites W1985953075 @default.
• W2016029316 cites W198753228 @default.
• W2016029316 cites W1989584103 @default.
• W2016029316 cites W1999213485 @default.
• W2016029316 cites W2002672149 @default.
• W2016029316 cites W2005481172 @default.
• W2016029316 cites W2007054796 @default.
• W2016029316 cites W2008309858 @default.
• W2016029316 cites W2010536179 @default.
• W2016029316 cites W2012524224 @default.
• W2016029316 cites W2019455970 @default.
• W2016029316 cites W2023028613 @default.
• W2016029316 cites W2024331611 @default.
• W2016029316 cites W2026245568 @default.
• W2016029316 cites W2026370952 @default.
• W2016029316 cites W2030051164 @default.
• W2016029316 cites W2032401333 @default.
• W2016029316 cites W2034883796 @default.
• W2016029316 cites W2035209628 @default.
• W2016029316 cites W2039573534 @default.
• W2016029316 cites W2040377223 @default.
• W2016029316 cites W2042492527 @default.
• W2016029316 cites W2043100866 @default.
• W2016029316 cites W2044875778 @default.
• W2016029316 cites W2052563447 @default.
• W2016029316 cites W2056261693 @default.
• W2016029316 cites W2059666235 @default.
• W2016029316 cites W2084949662 @default.
• W2016029316 cites W2089994382 @default.
• W2016029316 cites W2091276095 @default.
• W2016029316 cites W2091600194 @default.
• W2016029316 cites W2091649083 @default.
• W2016029316 cites W2093504415 @default.
• W2016029316 cites W2094831175 @default.
• W2016029316 cites W2096387523 @default.
• W2016029316 cites W2097463865 @default.
• W2016029316 cites W2098781795 @default.
• W2016029316 cites W2101783948 @default.
• W2016029316 cites W2105922705 @default.
• W2016029316 cites W2108663264 @default.
• W2016029316 cites W2116089633 @default.
• W2016029316 cites W2122995887 @default.
• W2016029316 cites W2133667940 @default.
• W2016029316 cites W2136134567 @default.
• W2016029316 cites W2136756281 @default.
• W2016029316 cites W2147009832 @default.
• W2016029316 cites W2155015540 @default.
• W2016029316 cites W2158609362 @default.
• W2016029316 cites W2162304109 @default.
• W2016029316 cites W2162787435 @default.
• W2016029316 cites W2171253232 @default.
• W2016029316 cites W4211073935 @default.
• W2016029316 cites W4231969745 @default.
• W2016029316 cites W4239103237 @default.
• W2016029316 cites W4250543930 @default.
• W2016029316 cites W4290960102 @default.
• W2016029316 cites W53287835 @default.
• W2016029316 doi "https://doi.org/10.1002/jmr.584" @default.
• W2016029316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12447900" @default.
• W2016029316 hasPublicationYear "2002" @default.
• W2016029316 type Work @default.
• W2016029316 sameAs 2016029316 @default.
• W2016029316 citedByCount "69" @default.
• W2016029316 countsByYear W20160293162012 @default.
• W2016029316 countsByYear W20160293162013 @default.
• W2016029316 countsByYear W20160293162014 @default.
• W2016029316 countsByYear W20160293162015 @default.
• W2016029316 countsByYear W20160293162016 @default.
• W2016029316 countsByYear W20160293162017 @default.
• W2016029316 countsByYear W20160293162018 @default.
• W2016029316 countsByYear W20160293162019 @default.
• W2016029316 countsByYear W20160293162020 @default.
• W2016029316 countsByYear W20160293162021 @default.
• W2016029316 countsByYear W20160293162022 @default.
• W2016029316 crossrefType "journal-article" @default.
• W2016029316 hasAuthorship W2016029316A5085260797 @default.
• W2016029316 hasBestOaLocation W20160293161 @default.
• W2016029316 hasConcept C111472728 @default.
• W2016029316 hasConcept C121332964 @default.
• W2016029316 hasConcept C124101348 @default.
• W2016029316 hasConcept C138885662 @default.
• W2016029316 hasConcept C14036430 @default.
• W2016029316 hasConcept C151730666 @default.
• W2016029316 hasConcept C159654299 @default.

• next