Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016029519> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2016029519 endingPage "235" @default.
- W2016029519 startingPage "230" @default.
- W2016029519 abstract "The structure of Pyrococcus furiosus DNA ligase (PfuLig), which architecturally resembles human DNA ligase I (hLigI), revealed that the C-terminal helix stabilizes the closed conformation through several ionic interactions between two domains (adenylylation domain (AdD) and C-terminal OB-fold domain (OBD)). This helix is oriented differently in DNA-bound hLigI, suggesting that the disruption of its interactions with AdD facilitates DNA binding. Previously, we demonstrated that the replacement of Asp540 with arginine improves the ligation activity. Here we report that the combination of the Asp540-replacement and the elimination of ionic residues in the helix, forming interactions with AdD, effectively enhanced the activity." @default.
- W2016029519 created "2016-06-24" @default.
- W2016029519 creator A5045012147 @default.
- W2016029519 creator A5052065215 @default.
- W2016029519 creator A5064466680 @default.
- W2016029519 creator A5067107875 @default.
- W2016029519 date "2013-11-05" @default.
- W2016029519 modified "2023-09-26" @default.
- W2016029519 title "Mutations of Asp540 and the domain-connecting residues synergistically enhance <i>Pyrococcus furiosus</i> DNA ligase activity" @default.
- W2016029519 cites W1964798261 @default.
- W2016029519 cites W1967354453 @default.
- W2016029519 cites W1976548111 @default.
- W2016029519 cites W1981435842 @default.
- W2016029519 cites W1995897604 @default.
- W2016029519 cites W2007437374 @default.
- W2016029519 cites W2029113606 @default.
- W2016029519 cites W2037240454 @default.
- W2016029519 cites W2069671060 @default.
- W2016029519 cites W2072785909 @default.
- W2016029519 cites W2082956579 @default.
- W2016029519 cites W2115121941 @default.
- W2016029519 cites W2125735909 @default.
- W2016029519 cites W2126856425 @default.
- W2016029519 doi "https://doi.org/10.1016/j.febslet.2013.10.037" @default.
- W2016029519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24211832" @default.
- W2016029519 hasPublicationYear "2013" @default.
- W2016029519 type Work @default.
- W2016029519 sameAs 2016029519 @default.
- W2016029519 citedByCount "7" @default.
- W2016029519 countsByYear W20160295192015 @default.
- W2016029519 countsByYear W20160295192016 @default.
- W2016029519 countsByYear W20160295192017 @default.
- W2016029519 countsByYear W20160295192018 @default.
- W2016029519 countsByYear W20160295192023 @default.
- W2016029519 crossrefType "journal-article" @default.
- W2016029519 hasAuthorship W2016029519A5045012147 @default.
- W2016029519 hasAuthorship W2016029519A5052065215 @default.
- W2016029519 hasAuthorship W2016029519A5064466680 @default.
- W2016029519 hasAuthorship W2016029519A5067107875 @default.
- W2016029519 hasBestOaLocation W20160295191 @default.
- W2016029519 hasConcept C104317684 @default.
- W2016029519 hasConcept C12554922 @default.
- W2016029519 hasConcept C175114707 @default.
- W2016029519 hasConcept C185592680 @default.
- W2016029519 hasConcept C18903297 @default.
- W2016029519 hasConcept C2776943354 @default.
- W2016029519 hasConcept C2778530040 @default.
- W2016029519 hasConcept C2779965526 @default.
- W2016029519 hasConcept C2908738455 @default.
- W2016029519 hasConcept C550995028 @default.
- W2016029519 hasConcept C552990157 @default.
- W2016029519 hasConcept C55493867 @default.
- W2016029519 hasConcept C86803240 @default.
- W2016029519 hasConceptScore W2016029519C104317684 @default.
- W2016029519 hasConceptScore W2016029519C12554922 @default.
- W2016029519 hasConceptScore W2016029519C175114707 @default.
- W2016029519 hasConceptScore W2016029519C185592680 @default.
- W2016029519 hasConceptScore W2016029519C18903297 @default.
- W2016029519 hasConceptScore W2016029519C2776943354 @default.
- W2016029519 hasConceptScore W2016029519C2778530040 @default.
- W2016029519 hasConceptScore W2016029519C2779965526 @default.
- W2016029519 hasConceptScore W2016029519C2908738455 @default.
- W2016029519 hasConceptScore W2016029519C550995028 @default.
- W2016029519 hasConceptScore W2016029519C552990157 @default.
- W2016029519 hasConceptScore W2016029519C55493867 @default.
- W2016029519 hasConceptScore W2016029519C86803240 @default.
- W2016029519 hasFunder F4320320912 @default.
- W2016029519 hasIssue "2" @default.
- W2016029519 hasLocation W20160295191 @default.
- W2016029519 hasLocation W20160295192 @default.
- W2016029519 hasOpenAccess W2016029519 @default.
- W2016029519 hasPrimaryLocation W20160295191 @default.
- W2016029519 hasRelatedWork W1973233877 @default.
- W2016029519 hasRelatedWork W1981435842 @default.
- W2016029519 hasRelatedWork W1990545177 @default.
- W2016029519 hasRelatedWork W2016029519 @default.
- W2016029519 hasRelatedWork W2055191896 @default.
- W2016029519 hasRelatedWork W2059461836 @default.
- W2016029519 hasRelatedWork W2069671060 @default.
- W2016029519 hasRelatedWork W2162737386 @default.
- W2016029519 hasRelatedWork W2423644403 @default.
- W2016029519 hasRelatedWork W2084248805 @default.
- W2016029519 hasVolume "588" @default.
- W2016029519 isParatext "false" @default.
- W2016029519 isRetracted "false" @default.
- W2016029519 magId "2016029519" @default.
- W2016029519 workType "article" @default.