Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016029556> ?p ?o ?g. }
- W2016029556 endingPage "164" @default.
- W2016029556 startingPage "154" @default.
- W2016029556 abstract "Proteolytic cleavage in an exposed loop of human tartrate-resistant acid phosphatase (TRAcP) with trypsin leads to a significant increase in activity. At each pH value between 3.25 and 8.0 the cleaved enzyme is more active. Substrate specificity is also influenced by proteolysis. Only the cleaved form is able to hydrolyze unactivated substrates efficiently, and at pH >6 cleaved TRAcP acquires a marked preference for ATP. The cleaved enzyme also has altered sensitivity to inhibitors. Interestingly, the magnitude and mode of inhibition by fluoride depends not only on the proteolytic state but also pH. The combined kinetic data imply a role of the loop residue D158 in catalysis in the cleaved enzyme. Notably, at low pH this residue may act as a proton donor for the leaving group. In this respect the mechanism of cleaved TRAcP resembles that of sweet potato purple acid phosphatase." @default.
- W2016029556 created "2016-06-24" @default.
- W2016029556 creator A5001004015 @default.
- W2016029556 creator A5007489810 @default.
- W2016029556 creator A5008028164 @default.
- W2016029556 creator A5026257435 @default.
- W2016029556 creator A5056866538 @default.
- W2016029556 creator A5066250216 @default.
- W2016029556 creator A5084003680 @default.
- W2016029556 creator A5086500057 @default.
- W2016029556 date "2005-07-01" @default.
- W2016029556 modified "2023-10-16" @default.
- W2016029556 title "Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation" @default.
- W2016029556 cites W1534572318 @default.
- W2016029556 cites W1572561340 @default.
- W2016029556 cites W1580813094 @default.
- W2016029556 cites W1590478241 @default.
- W2016029556 cites W1822169786 @default.
- W2016029556 cites W1823025905 @default.
- W2016029556 cites W1845439488 @default.
- W2016029556 cites W1963663894 @default.
- W2016029556 cites W1964768954 @default.
- W2016029556 cites W1968834775 @default.
- W2016029556 cites W1971115725 @default.
- W2016029556 cites W1982423863 @default.
- W2016029556 cites W1984226723 @default.
- W2016029556 cites W1984820528 @default.
- W2016029556 cites W1984965767 @default.
- W2016029556 cites W1991319540 @default.
- W2016029556 cites W1992367607 @default.
- W2016029556 cites W1997304859 @default.
- W2016029556 cites W1999576323 @default.
- W2016029556 cites W2001209015 @default.
- W2016029556 cites W2006385943 @default.
- W2016029556 cites W2007073637 @default.
- W2016029556 cites W2010750554 @default.
- W2016029556 cites W2013873050 @default.
- W2016029556 cites W2027390381 @default.
- W2016029556 cites W2028756633 @default.
- W2016029556 cites W2031900710 @default.
- W2016029556 cites W2034018882 @default.
- W2016029556 cites W2037504646 @default.
- W2016029556 cites W2039111221 @default.
- W2016029556 cites W2040687623 @default.
- W2016029556 cites W2044218027 @default.
- W2016029556 cites W2047094545 @default.
- W2016029556 cites W2048546942 @default.
- W2016029556 cites W2048781270 @default.
- W2016029556 cites W2049001186 @default.
- W2016029556 cites W2055787208 @default.
- W2016029556 cites W2059751568 @default.
- W2016029556 cites W2071119458 @default.
- W2016029556 cites W2071677610 @default.
- W2016029556 cites W2073609202 @default.
- W2016029556 cites W2090930525 @default.
- W2016029556 cites W2092494777 @default.
- W2016029556 cites W2096305507 @default.
- W2016029556 cites W2107228249 @default.
- W2016029556 cites W2109650101 @default.
- W2016029556 cites W2121214339 @default.
- W2016029556 cites W2131628538 @default.
- W2016029556 cites W2143563671 @default.
- W2016029556 cites W2150494686 @default.
- W2016029556 cites W2165539758 @default.
- W2016029556 cites W2167706373 @default.
- W2016029556 cites W2169061872 @default.
- W2016029556 cites W2397174584 @default.
- W2016029556 cites W4236727128 @default.
- W2016029556 doi "https://doi.org/10.1016/j.abb.2005.05.013" @default.
- W2016029556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15950921" @default.
- W2016029556 hasPublicationYear "2005" @default.
- W2016029556 type Work @default.
- W2016029556 sameAs 2016029556 @default.
- W2016029556 citedByCount "63" @default.
- W2016029556 countsByYear W20160295562012 @default.
- W2016029556 countsByYear W20160295562013 @default.
- W2016029556 countsByYear W20160295562014 @default.
- W2016029556 countsByYear W20160295562015 @default.
- W2016029556 countsByYear W20160295562016 @default.
- W2016029556 countsByYear W20160295562017 @default.
- W2016029556 countsByYear W20160295562018 @default.
- W2016029556 countsByYear W20160295562019 @default.
- W2016029556 countsByYear W20160295562020 @default.
- W2016029556 countsByYear W20160295562021 @default.
- W2016029556 countsByYear W20160295562022 @default.
- W2016029556 countsByYear W20160295562023 @default.
- W2016029556 crossrefType "journal-article" @default.
- W2016029556 hasAuthorship W2016029556A5001004015 @default.
- W2016029556 hasAuthorship W2016029556A5007489810 @default.
- W2016029556 hasAuthorship W2016029556A5008028164 @default.
- W2016029556 hasAuthorship W2016029556A5026257435 @default.
- W2016029556 hasAuthorship W2016029556A5056866538 @default.
- W2016029556 hasAuthorship W2016029556A5066250216 @default.
- W2016029556 hasAuthorship W2016029556A5084003680 @default.
- W2016029556 hasAuthorship W2016029556A5086500057 @default.
- W2016029556 hasConcept C151730666 @default.
- W2016029556 hasConcept C175156509 @default.
- W2016029556 hasConcept C178666793 @default.