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• W2016031341 abstract "The nuclear-associated protein product of the c-myc gene, p62c - myc, was assayed simultaneously with total DNA using flow cytometry in nuclei extracted from archival biopsies of serous papillary carcinoma of the ovary, the oncoprotein was probed with a synthetic peptide-induced mouse monoclonal antibody which was subsequently labeled with a fluorescenated rabbit anti-mouse immunoglobulin and DNA was assayed using the nucleic acid fluorochrome propidium iodide. Serous papillary ovarian carcinoma expressed significantly higher p62c − myc levels compared with normal ovary (P < 0.00003 Mann-Whitney U test). Biopsies classified as “borderline” low-potential malignancy exhibited levels between normal ovary and carcinoma. The difference between normal and “borderline” was significant at P < 0.003, but no difference between “borderline” and frankly invasive biopsies was observed, P = 0.149. There was no difference among the histological grades of carcinomas. All normal ovaries had diploid DNA content as did cases of “borderline” malignancy. The majority of cases of carcinoma, , were aneuploid. There was a statistically significant difference in the distribution of aneuploidy, P < 0.005, between invasive carcinomas and those classified as “borderline” low-potential malignancy." @default.
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• W2016031341 date "1987-10-01" @default.
• W2016031341 modified "2023-10-01" @default.
• W2016031341 title "Oncogene expression in ovarian cancer: A pilot study of c-myc oncoprotein in serous papillary ovarian cancer" @default.
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• W2016031341 doi "https://doi.org/10.1016/0090-8258(87)90207-1" @default.
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