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- W2016035269 abstract "The relationship between immunoregulatory T-cell function and the expression of T-cell subset-specific differentiation antigens was examined using a phenotypically anomalous human T-cell line (TCL), termed H-1. H-1 cells were found to express T11, extremely high levels of T3, but no T4 nor T8 antigen. Despite their lack of T4 antigen expression, H-1 cells could be actived by coculture with pokeweed mitogen (PWM), anti-T3 antibody, or autologous B cells to provide potent help for B-cell differentiation into plaque-forming cells (PFC). In contrast, H-1 cells did not suppress the PFC response triggered by PWM-activated T4+ cells. These results demonstrate that the expression of the T-cell subclass-specific differentiation antigen, T4, is not required for a T cell to become activated and to implement the program for helper function. In addition, enhanced expression of T3 on the T4−, T8−, H-1 cell surface may reflect a compensatory upregulation of the T3/Ti receptor complex on T cells which are deficient in these nonpolymorphic associative recognition structures." @default.
- W2016035269 created "2016-06-24" @default.
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- W2016035269 date "1986-11-01" @default.
- W2016035269 modified "2023-10-14" @default.
- W2016035269 title "Human helper-T-cell function does not require T4 antigen expression" @default.
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- W2016035269 doi "https://doi.org/10.1016/0008-8749(86)90072-9" @default.
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