FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016035695> ?p ?o ?g. }

• W2016035695 endingPage "e1090" @default.
• W2016035695 startingPage "e1090" @default.
• W2016035695 abstract "Background The FFAR1 receptor is expressed mainly in pancreatic beta cells and is activated by medium to long chain free fatty acids (FFAs), as well as by thiazolidinediones, resulting in elevated Ca2+ concentrations and promotion of insulin secretion. These properties suggest that FFAR1 could be a mediator of lipotoxicity and a potential candidate gene for Type 2 diabetes (T2D). We therefore investigated whether variations at the FFAR1 locus are associated with T2D and beta cell function. Methodology/Principal Findings We re-sequenced the FFAR1 region in 96 subjects (48 healthy and 48 T2D individuals) and found 13 single nucleotide polymorphisms (SNPs) 8 of which were not previously described. Two SNPs located in the upstream region of the FFAR1 gene (rs1978013 and rs1978014) were chosen and genotyped in 1929 patients with T2D and 1405 healthy control subjects. We observed an association of rs1978013 and rs1978014 with insulinogenic index in males (p = 0.024) and females (p = 0.032), respectively. After Bonferroni corrections, no association with T2D was found in the case-control material, however a haplotype consisting of the T-G alleles conferred protection against T2D (p = 0.0010). Conclusions/Significance Variation in the FFAR1 gene may contribute to impaired beta cell function in T2D." @default.
• W2016035695 created "2016-06-24" @default.
• W2016035695 creator A5028405616 @default.
• W2016035695 creator A5035080590 @default.
• W2016035695 creator A5040034760 @default.
• W2016035695 creator A5067601421 @default.
• W2016035695 creator A5074771810 @default.
• W2016035695 creator A5089395013 @default.
• W2016035695 date "2007-11-07" @default.
• W2016035695 modified "2023-10-16" @default.
• W2016035695 title "Variants in the FFAR1 Gene Are Associated with Beta Cell Function" @default.
• W2016035695 cites W1572743239 @default.
• W2016035695 cites W1973630137 @default.
• W2016035695 cites W1992286600 @default.
• W2016035695 cites W1994309646 @default.
• W2016035695 cites W1995573327 @default.
• W2016035695 cites W1997024473 @default.
• W2016035695 cites W2008895832 @default.
• W2016035695 cites W2028834965 @default.
• W2016035695 cites W2031414916 @default.
• W2016035695 cites W2040864865 @default.
• W2016035695 cites W2048755332 @default.
• W2016035695 cites W2056922888 @default.
• W2016035695 cites W2068241308 @default.
• W2016035695 cites W2084862721 @default.
• W2016035695 cites W2088888731 @default.
• W2016035695 cites W2092917950 @default.
• W2016035695 cites W2100403796 @default.
• W2016035695 cites W2100725292 @default.
• W2016035695 cites W2102964449 @default.
• W2016035695 cites W2103647262 @default.
• W2016035695 cites W2104622496 @default.
• W2016035695 cites W2115276803 @default.
• W2016035695 cites W2117693425 @default.
• W2016035695 cites W2126718294 @default.
• W2016035695 cites W2128326754 @default.
• W2016035695 cites W2134293572 @default.
• W2016035695 cites W2138842865 @default.
• W2016035695 cites W2139275774 @default.
• W2016035695 cites W2148383459 @default.
• W2016035695 cites W2149185205 @default.
• W2016035695 cites W2153550523 @default.
• W2016035695 cites W2155635136 @default.
• W2016035695 cites W2160234571 @default.
• W2016035695 cites W2160427718 @default.
• W2016035695 cites W2162530578 @default.
• W2016035695 cites W2172193286 @default.
• W2016035695 cites W2473364968 @default.
• W2016035695 doi "https://doi.org/10.1371/journal.pone.0001090" @default.
• W2016035695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2042513" @default.
• W2016035695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17987108" @default.
• W2016035695 hasPublicationYear "2007" @default.
• W2016035695 type Work @default.
• W2016035695 sameAs 2016035695 @default.
• W2016035695 citedByCount "13" @default.
• W2016035695 countsByYear W20160356952012 @default.
• W2016035695 countsByYear W20160356952013 @default.
• W2016035695 countsByYear W20160356952014 @default.
• W2016035695 countsByYear W20160356952016 @default.
• W2016035695 countsByYear W20160356952018 @default.
• W2016035695 countsByYear W20160356952021 @default.
• W2016035695 crossrefType "journal-article" @default.
• W2016035695 hasAuthorship W2016035695A5028405616 @default.
• W2016035695 hasAuthorship W2016035695A5035080590 @default.
• W2016035695 hasAuthorship W2016035695A5040034760 @default.
• W2016035695 hasAuthorship W2016035695A5067601421 @default.
• W2016035695 hasAuthorship W2016035695A5074771810 @default.
• W2016035695 hasAuthorship W2016035695A5089395013 @default.
• W2016035695 hasBestOaLocation W20160356951 @default.
• W2016035695 hasConcept C104317684 @default.
• W2016035695 hasConcept C126322002 @default.
• W2016035695 hasConcept C134018914 @default.
• W2016035695 hasConcept C135763542 @default.
• W2016035695 hasConcept C153209595 @default.
• W2016035695 hasConcept C170493617 @default.
• W2016035695 hasConcept C180754005 @default.
• W2016035695 hasConcept C2777180221 @default.
• W2016035695 hasConcept C2778938600 @default.
• W2016035695 hasConcept C2779306644 @default.
• W2016035695 hasConcept C32670627 @default.
• W2016035695 hasConcept C54355233 @default.
• W2016035695 hasConcept C555293320 @default.
• W2016035695 hasConcept C71924100 @default.
• W2016035695 hasConcept C86803240 @default.
• W2016035695 hasConcept C98335778 @default.
• W2016035695 hasConceptScore W2016035695C104317684 @default.
• W2016035695 hasConceptScore W2016035695C126322002 @default.
• W2016035695 hasConceptScore W2016035695C134018914 @default.
• W2016035695 hasConceptScore W2016035695C135763542 @default.
• W2016035695 hasConceptScore W2016035695C153209595 @default.
• W2016035695 hasConceptScore W2016035695C170493617 @default.
• W2016035695 hasConceptScore W2016035695C180754005 @default.
• W2016035695 hasConceptScore W2016035695C2777180221 @default.
• W2016035695 hasConceptScore W2016035695C2778938600 @default.
• W2016035695 hasConceptScore W2016035695C2779306644 @default.
• W2016035695 hasConceptScore W2016035695C32670627 @default.
• W2016035695 hasConceptScore W2016035695C54355233 @default.
• W2016035695 hasConceptScore W2016035695C555293320 @default.

• next