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• W2016035737 abstract "EphA2 gene silencing has been shown to result in anti-tumor efficacy. Here weconsidered whether silencing additional targets downstream of EphA2 would furtherenhance the therapeutic effect. EphA2 targeted siRNA was tested in combination witheither FAK or Src targeted siRNA using DOPC nanoliposomes in orthotopic models ofovarian carcinoma. The effects of therapy were determined by changes in tumor weight,proliferation (Ki-67), and microvessel density (CD31). In our initial in vivo study, EphA2plus FAK silencing resulted in the greatest reduction in tumor growth (by 73%, P" @default.
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• W2016035737 date "2009-06-01" @default.
• W2016035737 modified "2023-10-17" @default.
• W2016035737 title "Dual targeting of EphA2 and FAK in ovarian carcinoma" @default.
• W2016035737 doi "https://doi.org/10.4161/cbt.8.11.8523" @default.
• W2016035737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2748749" @default.
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