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• W2016038296 abstract "<abstitle>Abstract</abstitle><p><i>Background/Aim:</i> The role of angiotensin-converting enzyme (ACE)-related carboxypeptidase-2 (ACE2) in the regulation of the renin-angiotensin system is not well characterized. This study investigated the changes in the expression of ACE and ACE2 in the kidney in early diabetic rats. <i>Methods:</i> Streptozotocin-induced diabetic rats were examined. The concentrations of angiotensin II in plasma, urine, and renal cortex were measured by radioimmunoassay. The mRNA expression of ACE, ACE2, angiotensin II type 1 receptor (AT1R), and Mas receptor (MasR) in glomeruli and cortex was assessed using real-time PCR. The glomerular and cortical expression of ACE and ACE2 was assessed by immunohistochemistry. <i>Results:</i> For renal cortical tissue, the angiotensin II level was more intensified in the 8-week diabetic rats. Immunohistochemical experiments showed that ACE was increased, but ACE2 was decreased in the glomeruli of 8-week diabetic rats, while both ACE and ACE2 in the tubules were increased. The AT1R mRNA in the glomeruli was decreased, while the MasR mRNA was increased in 2-week diabetic rats. <i>Conclusion:</i> The combined effects of increased ACE and decreased ACE2 in glomeruli may be associated with the activation of the renin-angiotensin system in early diabetic rats, which is known to increase proteinuria.</p>" @default.
• W2016038296 created "2016-06-24" @default.
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• W2016038296 date "2008-08-04" @default.
• W2016038296 modified "2023-10-03" @default.
• W2016038296 title "Renal ACE and ACE2 Expression in Early Diabetic Rats" @default.
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• W2016038296 doi "https://doi.org/10.1159/000149586" @default.
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