Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016038944> ?p ?o ?g. }
- W2016038944 endingPage "806" @default.
- W2016038944 startingPage "796" @default.
- W2016038944 abstract "Abstract Purpose: To demonstrate that OKN007, a disulfonyl derivative of phenyl‐ tert ‐butyl nitrone (PBN), has anti‐glioma activity in the clinically relevant C6 rat glioma model using multi‐parametric magnetic resonance imaging. Materials and Methods: Twenty‐one rats were intracerebrally implanted with C6 cells and administered OKN007 or kept as controls. Animals were monitored with MRI at 7 Tesla (T), using morphologic, diffusion‐weighted and perfusion imaging, followed by histology and Western blots of angiogenesis and inflammatory markers. Results: OKN007 was found to decrease tumor volumes and increase survival. The glioma tissues of OKN007‐treated rats were found to have longitudinal apparent diffusion coefficients (ADC z ) of 0.76 ± 0.06 × 10 −3 mm 2 /s, similar to the contralateral tissue and significantly smaller than untreated gliomas (0.97 ± 0.13 × 10 −3 mm 2 /s). They had higher perfusion rates (66 ± 4 mL/100 g·min) than untreated gliomas (26 ± 7 mL/100 g·min). All examined molecular markers were decreased in OKN007‐treated rat gliomas, compared with elevated levels in untreated rats. Conclusion: MRI assessment was successfully used to monitor a decrease in tumor growth, and corresponding alterations in ADC and perfusion rates in rat C6 gliomas treated with the anti‐glioma agent, OKN007. J. Magn. Reson. Imaging 2010;31:796–806. ©2010 Wiley‐Liss, Inc." @default.
- W2016038944 created "2016-06-24" @default.
- W2016038944 creator A5001355296 @default.
- W2016038944 creator A5025282648 @default.
- W2016038944 creator A5043870806 @default.
- W2016038944 creator A5046466118 @default.
- W2016038944 creator A5048368457 @default.
- W2016038944 creator A5073331119 @default.
- W2016038944 creator A5078364606 @default.
- W2016038944 creator A5082447132 @default.
- W2016038944 creator A5043448653 @default.
- W2016038944 date "2010-03-29" @default.
- W2016038944 modified "2023-10-10" @default.
- W2016038944 title "Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging" @default.
- W2016038944 cites W118013182 @default.
- W2016038944 cites W1947016183 @default.
- W2016038944 cites W1965179669 @default.
- W2016038944 cites W1965642226 @default.
- W2016038944 cites W1965672071 @default.
- W2016038944 cites W1972365556 @default.
- W2016038944 cites W1976099054 @default.
- W2016038944 cites W1979438580 @default.
- W2016038944 cites W2006202974 @default.
- W2016038944 cites W2009633034 @default.
- W2016038944 cites W2020794437 @default.
- W2016038944 cites W2021648195 @default.
- W2016038944 cites W2025250901 @default.
- W2016038944 cites W2026448631 @default.
- W2016038944 cites W2027330893 @default.
- W2016038944 cites W2029580279 @default.
- W2016038944 cites W2030573007 @default.
- W2016038944 cites W2037945929 @default.
- W2016038944 cites W2039796268 @default.
- W2016038944 cites W2045115936 @default.
- W2016038944 cites W2046212337 @default.
- W2016038944 cites W2060060832 @default.
- W2016038944 cites W2069697787 @default.
- W2016038944 cites W2071667213 @default.
- W2016038944 cites W2080559907 @default.
- W2016038944 cites W2084761689 @default.
- W2016038944 cites W2094773294 @default.
- W2016038944 cites W2095143201 @default.
- W2016038944 cites W2100853822 @default.
- W2016038944 cites W2105215015 @default.
- W2016038944 cites W2115104536 @default.
- W2016038944 cites W2135873813 @default.
- W2016038944 cites W2136280619 @default.
- W2016038944 cites W2142540639 @default.
- W2016038944 cites W2157365364 @default.
- W2016038944 cites W2401478362 @default.
- W2016038944 cites W2726392696 @default.
- W2016038944 doi "https://doi.org/10.1002/jmri.22106" @default.
- W2016038944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20373422" @default.
- W2016038944 hasPublicationYear "2010" @default.
- W2016038944 type Work @default.
- W2016038944 sameAs 2016038944 @default.
- W2016038944 citedByCount "32" @default.
- W2016038944 countsByYear W20160389442012 @default.
- W2016038944 countsByYear W20160389442013 @default.
- W2016038944 countsByYear W20160389442014 @default.
- W2016038944 countsByYear W20160389442015 @default.
- W2016038944 countsByYear W20160389442016 @default.
- W2016038944 countsByYear W20160389442017 @default.
- W2016038944 countsByYear W20160389442018 @default.
- W2016038944 countsByYear W20160389442019 @default.
- W2016038944 countsByYear W20160389442020 @default.
- W2016038944 countsByYear W20160389442021 @default.
- W2016038944 countsByYear W20160389442022 @default.
- W2016038944 crossrefType "journal-article" @default.
- W2016038944 hasAuthorship W2016038944A5001355296 @default.
- W2016038944 hasAuthorship W2016038944A5025282648 @default.
- W2016038944 hasAuthorship W2016038944A5043448653 @default.
- W2016038944 hasAuthorship W2016038944A5043870806 @default.
- W2016038944 hasAuthorship W2016038944A5046466118 @default.
- W2016038944 hasAuthorship W2016038944A5048368457 @default.
- W2016038944 hasAuthorship W2016038944A5073331119 @default.
- W2016038944 hasAuthorship W2016038944A5078364606 @default.
- W2016038944 hasAuthorship W2016038944A5082447132 @default.
- W2016038944 hasConcept C126838900 @default.
- W2016038944 hasConcept C135691158 @default.
- W2016038944 hasConcept C142724271 @default.
- W2016038944 hasConcept C143409427 @default.
- W2016038944 hasConcept C146957229 @default.
- W2016038944 hasConcept C149550507 @default.
- W2016038944 hasConcept C2778227246 @default.
- W2016038944 hasConcept C2780394083 @default.
- W2016038944 hasConcept C2989005 @default.
- W2016038944 hasConcept C502942594 @default.
- W2016038944 hasConcept C57742111 @default.
- W2016038944 hasConcept C71924100 @default.
- W2016038944 hasConceptScore W2016038944C126838900 @default.
- W2016038944 hasConceptScore W2016038944C135691158 @default.
- W2016038944 hasConceptScore W2016038944C142724271 @default.
- W2016038944 hasConceptScore W2016038944C143409427 @default.
- W2016038944 hasConceptScore W2016038944C146957229 @default.
- W2016038944 hasConceptScore W2016038944C149550507 @default.
- W2016038944 hasConceptScore W2016038944C2778227246 @default.
- W2016038944 hasConceptScore W2016038944C2780394083 @default.