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- W2016040226 abstract "The in vitro study of transdermal therapeutic systems is of first importance to ensure a good quality control of such drug dosage forms. As several national Pharmacopoeias have published different in vitro methods, the authors aimed at comparing two of them. The first method described in the French Pharmacopoeia is a cell, consisting of a reservoir which contains a central chamber designed to receive the transdermal therapeutic system and a lid which fits onto the reservoir in order to centre the transdermal therapeutic system and delimit the area of diffusion. The second method described in the USP is a hollow cylinder mounted on the end of a steel rod like a paddle; the transdennal therapeutic systems are stuck on the outside of the cylinder, horizontally. In both cases the transdennal therapeutic systems are placed with the diffusion membrane outward, in direct contact with the medium (degassed distilled water). The transdermal therapeutic systems studied are composed of a reservoir one of the walls of which is a membrane of surface area 10 cm2 when containing 25 mg of trinitrine, or 20 cm2 when containing 50 mg of trinitrine. Released trinitrine was assayed using a HPLC technique. In spite of some small differences in the technique used (e.g. temperature 30° C or 32° C), the release of trinitrine is linear (zero-order) and the results are correlated by an equation of type y = ax + b and thus validated." @default.
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- W2016040226 date "1989-10-01" @default.
- W2016040226 modified "2023-09-25" @default.
- W2016040226 title "A comparative study of the release kinetics of trinitrine from transdermic therapeutic systems" @default.
- W2016040226 doi "https://doi.org/10.1016/0378-5173(89)90036-7" @default.
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