FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016040804> ?p ?o ?g. }

• W2016040804 endingPage "422" @default.
• W2016040804 startingPage "412" @default.
• W2016040804 abstract "This study argues that, in contrast to accepted excitotoxicity theory, O2/glucose deprivation damages neurons acutely by eliciting ischemic spreading depression (SD), a process not blocked by glutamate antagonists. In live rat hippocampal slices, the initiation, propagation, and resolution of SD can be imaged by monitoring wide-band changes in light transmittance (i.e., intrinsic optical signals). Oxygen/glucose deprivation for 10 minutes at 37.5 degrees C evokes a propagating wave of elevated light transmittance across the slice, representing the SD front. Within minutes, CA1 neurons in regions undergoing SD display irreversible damage in the form of field potential inactivation, swollen cell bodies, and extensively beaded dendrites, the latter revealed by single-cell injection of lucifer yellow. Importantly, glutamate receptor antagonists do not block SD induced by O2/glucose deprivation, nor do they prevent the resultant dendritic beading of CA1 neurons. However, CA1 neurons are spared if SD is suppressed by reducing the temperature to 35 degrees C during O2/glucose deprivation. This supports previous electrophysiologic evidence in vivo that SD during ischemia promotes acute neuronal damage and that glutamate antagonists are not protective of the metabolically stressed tissue. The authors propose that the inhibition of ischemic SD should be targeted as an important therapeutic strategy against stroke damage." @default.
• W2016040804 created "2016-06-24" @default.
• W2016040804 creator A5041699483 @default.
• W2016040804 creator A5050458060 @default.
• W2016040804 creator A5087468075 @default.
• W2016040804 date "2000-02-01" @default.
• W2016040804 modified "2023-09-30" @default.
• W2016040804 title "Glutamate Does Not Mediate Acute Neuronal Damage after Spreading Depression Induced by O₂/Glucose Deprivation in the Hippocampal Slice" @default.
• W2016040804 cites W1533229430 @default.
• W2016040804 cites W1927904330 @default.
• W2016040804 cites W1968305429 @default.
• W2016040804 cites W1975850619 @default.
• W2016040804 cites W1976265701 @default.
• W2016040804 cites W1984571713 @default.
• W2016040804 cites W1989483418 @default.
• W2016040804 cites W1994638214 @default.
• W2016040804 cites W1994907910 @default.
• W2016040804 cites W1996057550 @default.
• W2016040804 cites W2006904109 @default.
• W2016040804 cites W2023402127 @default.
• W2016040804 cites W2024085735 @default.
• W2016040804 cites W2026044579 @default.
• W2016040804 cites W2044636914 @default.
• W2016040804 cites W2046938559 @default.
• W2016040804 cites W2048533614 @default.
• W2016040804 cites W2051143596 @default.
• W2016040804 cites W2056539638 @default.
• W2016040804 cites W2064133423 @default.
• W2016040804 cites W2064158371 @default.
• W2016040804 cites W2075166773 @default.
• W2016040804 cites W2075350214 @default.
• W2016040804 cites W2075473660 @default.
• W2016040804 cites W2076878418 @default.
• W2016040804 cites W2077643795 @default.
• W2016040804 cites W2100482324 @default.
• W2016040804 cites W2129266568 @default.
• W2016040804 cites W2131054267 @default.
• W2016040804 cites W2161759029 @default.
• W2016040804 cites W2217637761 @default.
• W2016040804 cites W2398246806 @default.
• W2016040804 cites W2399997114 @default.
• W2016040804 cites W4251597444 @default.
• W2016040804 doi "https://doi.org/10.1097/00004647-200002000-00024" @default.
• W2016040804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10698080" @default.
• W2016040804 hasPublicationYear "2000" @default.
• W2016040804 type Work @default.
• W2016040804 sameAs 2016040804 @default.
• W2016040804 citedByCount "87" @default.
• W2016040804 countsByYear W20160408042012 @default.
• W2016040804 countsByYear W20160408042013 @default.
• W2016040804 countsByYear W20160408042014 @default.
• W2016040804 countsByYear W20160408042015 @default.
• W2016040804 countsByYear W20160408042016 @default.
• W2016040804 countsByYear W20160408042017 @default.
• W2016040804 countsByYear W20160408042018 @default.
• W2016040804 countsByYear W20160408042019 @default.
• W2016040804 countsByYear W20160408042020 @default.
• W2016040804 countsByYear W20160408042021 @default.
• W2016040804 countsByYear W20160408042022 @default.
• W2016040804 countsByYear W20160408042023 @default.
• W2016040804 crossrefType "journal-article" @default.
• W2016040804 hasAuthorship W2016040804A5041699483 @default.
• W2016040804 hasAuthorship W2016040804A5050458060 @default.
• W2016040804 hasAuthorship W2016040804A5087468075 @default.
• W2016040804 hasBestOaLocation W20160408041 @default.
• W2016040804 hasConcept C122356138 @default.
• W2016040804 hasConcept C126322002 @default.
• W2016040804 hasConcept C134018914 @default.
• W2016040804 hasConcept C148762608 @default.
• W2016040804 hasConcept C158157758 @default.
• W2016040804 hasConcept C169760540 @default.
• W2016040804 hasConcept C170493617 @default.
• W2016040804 hasConcept C185263204 @default.
• W2016040804 hasConcept C185592680 @default.
• W2016040804 hasConcept C2778541695 @default.
• W2016040804 hasConcept C2779486281 @default.
• W2016040804 hasConcept C2781012912 @default.
• W2016040804 hasConcept C2781161787 @default.
• W2016040804 hasConcept C29694410 @default.
• W2016040804 hasConcept C42219234 @default.
• W2016040804 hasConcept C541997718 @default.
• W2016040804 hasConcept C61174792 @default.
• W2016040804 hasConcept C67018056 @default.
• W2016040804 hasConcept C71924100 @default.
• W2016040804 hasConcept C79879829 @default.
• W2016040804 hasConcept C86803240 @default.
• W2016040804 hasConcept C95444343 @default.
• W2016040804 hasConceptScore W2016040804C122356138 @default.
• W2016040804 hasConceptScore W2016040804C126322002 @default.
• W2016040804 hasConceptScore W2016040804C134018914 @default.
• W2016040804 hasConceptScore W2016040804C148762608 @default.
• W2016040804 hasConceptScore W2016040804C158157758 @default.
• W2016040804 hasConceptScore W2016040804C169760540 @default.
• W2016040804 hasConceptScore W2016040804C170493617 @default.
• W2016040804 hasConceptScore W2016040804C185263204 @default.
• W2016040804 hasConceptScore W2016040804C185592680 @default.
• W2016040804 hasConceptScore W2016040804C2778541695 @default.
• W2016040804 hasConceptScore W2016040804C2779486281 @default.

• next