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- W2016043507 abstract "The metabolic activities of a given gut bacterium or gut commensal community fluctuate in a manner largely depending on the physicochemical parameters within the gut niche. Recognition of the bacterial metabolic status in situ, by a sensing of the gut metabolites as a signature of a specific bacterial metabolic activity, has been suggested to be a highly beneficial means for the host to maintain gut–microbe homeostasis. Recently, analysis of Drosophila gut immunity revealed that bacterial-derived uracil and uracil-modulated intestinal reactive oxygen species (ROS) generation play a pivotal role in diverse aspects of host–microbe interactions, such as pathogen clearance, commensal protection, intestinal cell regeneration, colitogenesis, and possibly also interorgan immunological communication. A deeper understanding of the role of uracil in Drosophila immunity will provide additional insight into the molecular mechanisms underlying host–microbe symbiosis and dysbiosis." @default.
- W2016043507 created "2016-06-24" @default.
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- W2016043507 date "2014-10-01" @default.
- W2016043507 modified "2023-09-24" @default.
- W2016043507 title "Homeostasis between gut-associated microorganisms and the immune system in Drosophila" @default.
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- W2016043507 doi "https://doi.org/10.1016/j.coi.2014.06.006" @default.
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