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• W2016044199 abstract "Many bacterial toxins utilize cell surface glycoconjugate receptors for attachment to target cells. In the present study the potential carbohydrate binding of Helicobacter pylori vacuolating cytotoxin VacA was investigated by binding to human gastric glycosphingolipids on thin-layer chromatograms. Thereby a distinct binding of the toxin to two compounds in the non-acid glycosphingolipid fraction was detected. The VacA-binding glycosphingolipids were isolated and characterized by mass spectrometry and proton NMR as galactosylceramide (Galβ1Cer) and galabiosylceramide (Galα4Galβ1Cer). Comparison of the binding preferences of the protein to reference glycosphingolipids from other sources showed an additional recognition of glucosylceramide (Glcβ1Cer), lactosylceramide (Galβ4Glcβ1Cer) and globotriaosylceramide (Galα4Galβ4Glcβ1Cer). No binding to the glycosphingolipids recognized by the VacA holotoxin was obtained with a mutant toxin with deletion of the 37 kDa fragment of VacA (P58 molecule). Collectively our data show that the VacA cytotoxin is a glycosphingolipid binding protein, where the 37 kDa moiety is required for carbohydrate recognition. The ability to bind to short chain glycosphingolipids will position the toxin close to the cell membrane, which may facilitate toxin internalization." @default.
• W2016044199 created "2016-06-24" @default.
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• W2016044199 date "2007-04-01" @default.
• W2016044199 modified "2023-10-14" @default.
• W2016044199 title "Human gastric glycosphingolipids recognized by Helicobacter pylori vacuolating cytotoxin VacA" @default.
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• W2016044199 doi "https://doi.org/10.1016/j.micinf.2007.01.023" @default.
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