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- W2016044475 endingPage "1436" @default.
- W2016044475 startingPage "1428" @default.
- W2016044475 abstract "The last 20 years have seen major progress in the treatment of relapsing–remitting multiple sclerosis (RRMS) using a variety of drugs targeting immune dysfunction. In contrast, all clinical trials of such agents in primary progressive multiple sclerosis (PPMS) have failed and there is limited evidence of their efficacy in secondary progressive disease. Evolving concepts of the complex interplay between inflammatory and neurodegenerative processes across the course of multiple sclerosis (MS) may explain this discrepancy. This paper will provide an up-to-date overview of the rationale and results of the published clinical trials that have sought to alter the trajectory of both primary and secondary MS, considering studies involving drugs with a primary immune target and also those aiming for neuroprotection. Future areas of study will be discussed, building on these results combined with the experience of treating RRMS and new concepts emerging from laboratory science and animal models." @default.
- W2016044475 created "2016-06-24" @default.
- W2016044475 creator A5043499649 @default.
- W2016044475 date "2013-09-23" @default.
- W2016044475 modified "2023-10-18" @default.
- W2016044475 title "Disease-modifying treatments for progressive multiple sclerosis" @default.
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