FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016044957> ?p ?o ?g. }

• W2016044957 endingPage "2012" @default.
• W2016044957 startingPage "2002" @default.
• W2016044957 abstract "Acute myeloid leukemia (AML), a type of blood cancer, is characterized by an increase in the number of abnormal white blood cells in the bone marrow, frequently causing hematopoietic insufficiency. It is a heterogeneous disease featuring cytogenetic aberrations, recurrent somatic mutations and alterations in gene expression. DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) is closely associated with epigenetic modifications in mammalian development and disease. More recent studies have identified recurrent somatic mutations in DNMT3A in AML, most of which are heterozygous. The DNMT3A R882 codon is a mutational hotspot. The frequency of DNMT3A mutations varies among different countries, but mutations have been found to be associated with cytogenetics, age, white blood cell (WBC) count, prognosis and response of patients to chemotherapy. The normal function of DNMT3A can be disrupted by these mutations, which subsequently results in an abnormality of epigenetic modification. These data suggest that mutations in the DNMT3A gene represent a novel class of mutations in AML with distinct biological and clinical features. Further studies are needed to elucidate the exact molecular mechanism and function of DNMT3A mutations in leukemogenesis." @default.
• W2016044957 created "2016-06-24" @default.
• W2016044957 creator A5009313040 @default.
• W2016044957 creator A5052738583 @default.
• W2016044957 date "2014-03-07" @default.
• W2016044957 modified "2023-10-16" @default.
• W2016044957 title "Acute myeloid leukemia with DNMT3A mutations" @default.
• W2016044957 cites W1255676896 @default.
• W2016044957 cites W1508163514 @default.
• W2016044957 cites W1571174293 @default.
• W2016044957 cites W1577875429 @default.
• W2016044957 cites W1584887708 @default.
• W2016044957 cites W1601398749 @default.
• W2016044957 cites W1685529373 @default.
• W2016044957 cites W1808990955 @default.
• W2016044957 cites W1965530514 @default.
• W2016044957 cites W1966379304 @default.
• W2016044957 cites W1967386932 @default.
• W2016044957 cites W1968717432 @default.
• W2016044957 cites W1973759523 @default.
• W2016044957 cites W1976097852 @default.
• W2016044957 cites W1979818557 @default.
• W2016044957 cites W1981042908 @default.
• W2016044957 cites W1981438266 @default.
• W2016044957 cites W1993362540 @default.
• W2016044957 cites W1995789257 @default.
• W2016044957 cites W1999580244 @default.
• W2016044957 cites W1999886232 @default.
• W2016044957 cites W2004743749 @default.
• W2016044957 cites W2006040339 @default.
• W2016044957 cites W2006413310 @default.
• W2016044957 cites W2010318973 @default.
• W2016044957 cites W2010455776 @default.
• W2016044957 cites W2012959081 @default.
• W2016044957 cites W2018243060 @default.
• W2016044957 cites W2018304597 @default.
• W2016044957 cites W2022301078 @default.
• W2016044957 cites W2023593657 @default.
• W2016044957 cites W2027687637 @default.
• W2016044957 cites W2028803880 @default.
• W2016044957 cites W2029422337 @default.
• W2016044957 cites W2036832665 @default.
• W2016044957 cites W2041191257 @default.
• W2016044957 cites W2046829201 @default.
• W2016044957 cites W2050985416 @default.
• W2016044957 cites W2059300459 @default.
• W2016044957 cites W2061164841 @default.
• W2016044957 cites W2064268598 @default.
• W2016044957 cites W2066599338 @default.
• W2016044957 cites W2068311105 @default.
• W2016044957 cites W2073793098 @default.
• W2016044957 cites W2074464967 @default.
• W2016044957 cites W2075796965 @default.
• W2016044957 cites W2076426515 @default.
• W2016044957 cites W2079944042 @default.
• W2016044957 cites W2081773938 @default.
• W2016044957 cites W2082605238 @default.
• W2016044957 cites W2088621765 @default.
• W2016044957 cites W2094703195 @default.
• W2016044957 cites W2096638244 @default.
• W2016044957 cites W2108002997 @default.
• W2016044957 cites W2109554035 @default.
• W2016044957 cites W2115707319 @default.
• W2016044957 cites W2117291755 @default.
• W2016044957 cites W2125034361 @default.
• W2016044957 cites W2127130948 @default.
• W2016044957 cites W2130966079 @default.
• W2016044957 cites W2131072337 @default.
• W2016044957 cites W2134490567 @default.
• W2016044957 cites W2138417167 @default.
• W2016044957 cites W2140058995 @default.
• W2016044957 cites W2140929811 @default.
• W2016044957 cites W2149790281 @default.
• W2016044957 cites W2150470057 @default.
• W2016044957 cites W2151802396 @default.
• W2016044957 cites W2157326360 @default.
• W2016044957 cites W2159789606 @default.
• W2016044957 cites W2999833470 @default.
• W2016044957 cites W4312790597 @default.
• W2016044957 cites W4385970358 @default.
• W2016044957 cites W84052312 @default.
• W2016044957 doi "https://doi.org/10.3109/10428194.2013.869802" @default.
• W2016044957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24283755" @default.
• W2016044957 hasPublicationYear "2014" @default.
• W2016044957 type Work @default.
• W2016044957 sameAs 2016044957 @default.
• W2016044957 citedByCount "16" @default.
• W2016044957 countsByYear W20160449572014 @default.
• W2016044957 countsByYear W20160449572015 @default.
• W2016044957 countsByYear W20160449572016 @default.
• W2016044957 countsByYear W20160449572017 @default.
• W2016044957 countsByYear W20160449572018 @default.
• W2016044957 countsByYear W20160449572019 @default.
• W2016044957 countsByYear W20160449572020 @default.
• W2016044957 countsByYear W20160449572021 @default.
• W2016044957 crossrefType "journal-article" @default.
• W2016044957 hasAuthorship W2016044957A5009313040 @default.
• W2016044957 hasAuthorship W2016044957A5052738583 @default.

• next