FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016045900> ?p ?o ?g. }

• W2016045900 endingPage "120" @default.
• W2016045900 startingPage "115" @default.
• W2016045900 abstract "In Brief Acute pulmonary embolism (APE) is a major cause of pulmonary hypertension and death. We examined the effects of sildenafil on the hemodynamic changes caused by APE in anesthetized dogs. Sham-operated dogs (n = 3) received only saline. APE was induced by stepwise IV injections of 300 μm microspheres in amounts adjusted to increase mean pulmonary artery pressures by 20 mm Hg. Hemodynamic evaluation was performed at baseline, after APE was induced, and then after sildenafil 0.25 mg/kg (n = 8), or sildenafil 1 mg/kg + 0.3 mg · kg−1 · h−1 (n = 8) or saline (n = 9) infusions were started. Similar experiments were conducted to examine the effects of sildenafil in rat isolated perfused lung preparation. Plasma thiobarbituric acid reactive species were also determined in both studies to measure oxidative stress. Both doses of sildenafil reduced mean pulmonary artery pressures in dogs by approximately 8 to 16 mm Hg (both P < 0.05) and attenuated the increase in oxidative stress after APE. Mean arterial blood pressure remained unaltered after both doses of sildenafil. Sildenafil produced similar effects after APE in rat isolated perfused lung preparation. These findings indicate that IV sildenafil can selectively attenuate the increases in mean pulmonary artery pressures after APE, possibly through antioxidant mechanisms. IMPLICATIONS: We evaluated the effects of IV sildenafil in two animal models of acute pulmonary embolism. IV sildenafil selectively decreased pulmonary vascular resistance and pulmonary artery pressure and attenuated the increase in oxidative stress after acute pulmonary embolism in both models." @default.
• W2016045900 created "2016-06-24" @default.
• W2016045900 creator A5010550862 @default.
• W2016045900 creator A5014804546 @default.
• W2016045900 creator A5022834761 @default.
• W2016045900 creator A5038181755 @default.
• W2016045900 creator A5072496715 @default.
• W2016045900 creator A5072613067 @default.
• W2016045900 date "2005-07-01" @default.
• W2016045900 modified "2023-10-18" @default.
• W2016045900 title "The Effect of Sildenafil on Pulmonary Embolism-Induced Oxidative Stress and Pulmonary Hypertension" @default.
• W2016045900 cites W1995919025 @default.
• W2016045900 cites W2003373618 @default.
• W2016045900 cites W2013722019 @default.
• W2016045900 cites W2015156318 @default.
• W2016045900 cites W2019759992 @default.
• W2016045900 cites W2021965311 @default.
• W2016045900 cites W2029879665 @default.
• W2016045900 cites W2033568251 @default.
• W2016045900 cites W2036613128 @default.
• W2016045900 cites W2036828118 @default.
• W2016045900 cites W2039140390 @default.
• W2016045900 cites W2052825698 @default.
• W2016045900 cites W2067508004 @default.
• W2016045900 cites W2069888510 @default.
• W2016045900 cites W2093518775 @default.
• W2016045900 cites W2094151199 @default.
• W2016045900 cites W2095898150 @default.
• W2016045900 cites W2111836353 @default.
• W2016045900 cites W2112498799 @default.
• W2016045900 cites W2114079218 @default.
• W2016045900 cites W2114893250 @default.
• W2016045900 cites W2121819343 @default.
• W2016045900 cites W2138448233 @default.
• W2016045900 cites W2149688277 @default.
• W2016045900 cites W2160314451 @default.
• W2016045900 cites W2236223798 @default.
• W2016045900 cites W3027783053 @default.
• W2016045900 cites W4231702115 @default.
• W2016045900 cites W4248870929 @default.
• W2016045900 cites W4252265106 @default.
• W2016045900 doi "https://doi.org/10.1213/01.ane.0000153499.10558.f3" @default.
• W2016045900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15976216" @default.
• W2016045900 hasPublicationYear "2005" @default.
• W2016045900 type Work @default.
• W2016045900 sameAs 2016045900 @default.
• W2016045900 citedByCount "69" @default.
• W2016045900 countsByYear W20160459002012 @default.
• W2016045900 countsByYear W20160459002013 @default.
• W2016045900 countsByYear W20160459002014 @default.
• W2016045900 countsByYear W20160459002015 @default.
• W2016045900 countsByYear W20160459002018 @default.
• W2016045900 countsByYear W20160459002019 @default.
• W2016045900 countsByYear W20160459002020 @default.
• W2016045900 countsByYear W20160459002021 @default.
• W2016045900 crossrefType "journal-article" @default.
• W2016045900 hasAuthorship W2016045900A5010550862 @default.
• W2016045900 hasAuthorship W2016045900A5014804546 @default.
• W2016045900 hasAuthorship W2016045900A5022834761 @default.
• W2016045900 hasAuthorship W2016045900A5038181755 @default.
• W2016045900 hasAuthorship W2016045900A5072496715 @default.
• W2016045900 hasAuthorship W2016045900A5072613067 @default.
• W2016045900 hasBestOaLocation W20160459001 @default.
• W2016045900 hasConcept C126322002 @default.
• W2016045900 hasConcept C164705383 @default.
• W2016045900 hasConcept C178853913 @default.
• W2016045900 hasConcept C2776151105 @default.
• W2016045900 hasConcept C2776265017 @default.
• W2016045900 hasConcept C2776768464 @default.
• W2016045900 hasConcept C2777714996 @default.
• W2016045900 hasConcept C2780930700 @default.
• W2016045900 hasConcept C2780940725 @default.
• W2016045900 hasConcept C42219234 @default.
• W2016045900 hasConcept C58245268 @default.
• W2016045900 hasConcept C71924100 @default.
• W2016045900 hasConceptScore W2016045900C126322002 @default.
• W2016045900 hasConceptScore W2016045900C164705383 @default.
• W2016045900 hasConceptScore W2016045900C178853913 @default.
• W2016045900 hasConceptScore W2016045900C2776151105 @default.
• W2016045900 hasConceptScore W2016045900C2776265017 @default.
• W2016045900 hasConceptScore W2016045900C2776768464 @default.
• W2016045900 hasConceptScore W2016045900C2777714996 @default.
• W2016045900 hasConceptScore W2016045900C2780930700 @default.
• W2016045900 hasConceptScore W2016045900C2780940725 @default.
• W2016045900 hasConceptScore W2016045900C42219234 @default.
• W2016045900 hasConceptScore W2016045900C58245268 @default.
• W2016045900 hasConceptScore W2016045900C71924100 @default.
• W2016045900 hasIssue "1" @default.
• W2016045900 hasLocation W20160459001 @default.
• W2016045900 hasLocation W20160459002 @default.
• W2016045900 hasLocation W20160459003 @default.
• W2016045900 hasOpenAccess W2016045900 @default.
• W2016045900 hasPrimaryLocation W20160459001 @default.
• W2016045900 hasRelatedWork W1558132769 @default.
• W2016045900 hasRelatedWork W1982601738 @default.
• W2016045900 hasRelatedWork W1989128070 @default.
• W2016045900 hasRelatedWork W2008435861 @default.
• W2016045900 hasRelatedWork W2016646568 @default.

• next