Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016046811> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2016046811 endingPage "228" @default.
- W2016046811 startingPage "224" @default.
- W2016046811 abstract "New effective therapy is desirable for outpatients with advanced non-small-cell lung cancer (NSCLC). Fractionated administration of paclitaxel may be less toxic and more active against NSCLC. The aim of this study was to evaluate the activity and toxicity of weekly paclitaxel therapy for chemotherapy-naive NSCLC.Patients with pathological or cytological diagnosis of NSCLC, measurable lesions, and no prior therapy were enrolled. We administered weekly infusions of 80 mg/m(2) paclitaxel 3 times in a 4-week cycle. In the absence of progressive disease or intolerable toxicity, we treated each patient for a minimum of four cycles.Of 35 patients enrolled, 17 patients achieved partial response, although no complete responses were observed (response rate 49%; 95% confidence interval 32-66%). The median survival time was 55 weeks (range 6-93 weeks). Grade 3 or 4 leukopenia occurred in only 1 patient (3%). Neurotoxicity was the most frequent adverse effect (grades 1 and 2, 26 and 3%, respectively). Serious toxicity, observed in 2 patients (6%), was interstitial pneumonia, and 1 patient died from sequela.Low-dose weekly paclitaxel is a promising therapy for advanced NSCLC with high effectiveness and low toxicity." @default.
- W2016046811 created "2016-06-24" @default.
- W2016046811 creator A5000703352 @default.
- W2016046811 creator A5005767516 @default.
- W2016046811 creator A5007746744 @default.
- W2016046811 creator A5015118724 @default.
- W2016046811 creator A5022500691 @default.
- W2016046811 creator A5053435376 @default.
- W2016046811 creator A5058635421 @default.
- W2016046811 creator A5060956511 @default.
- W2016046811 creator A5062357486 @default.
- W2016046811 creator A5070432030 @default.
- W2016046811 creator A5078139392 @default.
- W2016046811 creator A5084973794 @default.
- W2016046811 date "2003-01-01" @default.
- W2016046811 modified "2023-09-24" @default.
- W2016046811 title "Phase II Trial of Weekly Paclitaxel in Previously Untreated Advanced Non-Small-Cell Lung Cancer" @default.
- W2016046811 cites W2034288807 @default.
- W2016046811 cites W2092977595 @default.
- W2016046811 doi "https://doi.org/10.1159/000074475" @default.
- W2016046811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14657596" @default.
- W2016046811 hasPublicationYear "2003" @default.
- W2016046811 type Work @default.
- W2016046811 sameAs 2016046811 @default.
- W2016046811 citedByCount "19" @default.
- W2016046811 countsByYear W20160468112012 @default.
- W2016046811 countsByYear W20160468112016 @default.
- W2016046811 countsByYear W20160468112017 @default.
- W2016046811 countsByYear W20160468112018 @default.
- W2016046811 countsByYear W20160468112019 @default.
- W2016046811 countsByYear W20160468112020 @default.
- W2016046811 countsByYear W20160468112021 @default.
- W2016046811 crossrefType "journal-article" @default.
- W2016046811 hasAuthorship W2016046811A5000703352 @default.
- W2016046811 hasAuthorship W2016046811A5005767516 @default.
- W2016046811 hasAuthorship W2016046811A5007746744 @default.
- W2016046811 hasAuthorship W2016046811A5015118724 @default.
- W2016046811 hasAuthorship W2016046811A5022500691 @default.
- W2016046811 hasAuthorship W2016046811A5053435376 @default.
- W2016046811 hasAuthorship W2016046811A5058635421 @default.
- W2016046811 hasAuthorship W2016046811A5060956511 @default.
- W2016046811 hasAuthorship W2016046811A5062357486 @default.
- W2016046811 hasAuthorship W2016046811A5070432030 @default.
- W2016046811 hasAuthorship W2016046811A5078139392 @default.
- W2016046811 hasAuthorship W2016046811A5084973794 @default.
- W2016046811 hasConcept C126322002 @default.
- W2016046811 hasConcept C141071460 @default.
- W2016046811 hasConcept C143998085 @default.
- W2016046811 hasConcept C197934379 @default.
- W2016046811 hasConcept C2776256026 @default.
- W2016046811 hasConcept C2776694085 @default.
- W2016046811 hasConcept C2776907518 @default.
- W2016046811 hasConcept C2777292972 @default.
- W2016046811 hasConcept C2777609351 @default.
- W2016046811 hasConcept C2778822529 @default.
- W2016046811 hasConcept C2780873365 @default.
- W2016046811 hasConcept C2781047374 @default.
- W2016046811 hasConcept C29730261 @default.
- W2016046811 hasConcept C71924100 @default.
- W2016046811 hasConcept C90924648 @default.
- W2016046811 hasConceptScore W2016046811C126322002 @default.
- W2016046811 hasConceptScore W2016046811C141071460 @default.
- W2016046811 hasConceptScore W2016046811C143998085 @default.
- W2016046811 hasConceptScore W2016046811C197934379 @default.
- W2016046811 hasConceptScore W2016046811C2776256026 @default.
- W2016046811 hasConceptScore W2016046811C2776694085 @default.
- W2016046811 hasConceptScore W2016046811C2776907518 @default.
- W2016046811 hasConceptScore W2016046811C2777292972 @default.
- W2016046811 hasConceptScore W2016046811C2777609351 @default.
- W2016046811 hasConceptScore W2016046811C2778822529 @default.
- W2016046811 hasConceptScore W2016046811C2780873365 @default.
- W2016046811 hasConceptScore W2016046811C2781047374 @default.
- W2016046811 hasConceptScore W2016046811C29730261 @default.
- W2016046811 hasConceptScore W2016046811C71924100 @default.
- W2016046811 hasConceptScore W2016046811C90924648 @default.
- W2016046811 hasIssue "3" @default.
- W2016046811 hasLocation W20160468111 @default.
- W2016046811 hasLocation W20160468112 @default.
- W2016046811 hasOpenAccess W2016046811 @default.
- W2016046811 hasPrimaryLocation W20160468111 @default.
- W2016046811 hasRelatedWork W2016046811 @default.
- W2016046811 hasRelatedWork W2020274747 @default.
- W2016046811 hasRelatedWork W2053778437 @default.
- W2016046811 hasRelatedWork W2055244776 @default.
- W2016046811 hasRelatedWork W2187491254 @default.
- W2016046811 hasRelatedWork W2300554255 @default.
- W2016046811 hasRelatedWork W2352614411 @default.
- W2016046811 hasRelatedWork W2383394202 @default.
- W2016046811 hasRelatedWork W2396672633 @default.
- W2016046811 hasRelatedWork W2413020017 @default.
- W2016046811 hasVolume "65" @default.
- W2016046811 isParatext "false" @default.
- W2016046811 isRetracted "false" @default.
- W2016046811 magId "2016046811" @default.
- W2016046811 workType "article" @default.