FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016050222> ?p ?o ?g. }

• W2016050222 endingPage "2087" @default.
• W2016050222 startingPage "2082" @default.
• W2016050222 abstract "The aim of this study was to evaluate the efficacy of using matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9)-cleavable ratiometric activatable cell-penetrating peptides (RACPPs) conjugated to Cy5 and Cy7 fluorophores to accurately label pancreatic cancer for fluorescence-guided surgery (FGS) in an orthotopic mouse model. Orthotopic mouse models were established using MiaPaCa-2-GFP human pancreatic cancer cells. Two weeks after implantation, tumor-bearing mice were randomized to conventional white light reflectance (WLR) surgery or FGS. FGS was performed at far-red and infrared wavelengths with a customized fluorescence-dissecting microscope 2 h after injection of MMP-2 and MMP-9-cleavable RACPPs. Green fluorescence imaging of the GFP-labeled cancer cells was used to assess the effectiveness of surgical resection and monitor recurrence. At 8 weeks, mice were sacrificed to evaluate tumor burden and metastases. Mice in the WLR group had larger primary tumors than mice in the FGS group at termination [1.72 g ± standard error (SE) 0.58 vs. 0.25 g ± SE 0.14; respectively, p = 0.026). Mean disease-free survival was significantly lengthened from 5.33 weeks in the WLR group to 7.38 weeks in the FGS group (p = 0.02). Recurrence rates were lower in the FGS group than in the WLR group (38 vs. 73 %; p = 0.049). This translated into lower local and distant recurrence rates for FGS compared to WLR (31 vs. 67 for local recurrence, respectively, and 25 vs. 60 % for distant recurrence, respectively). Metastatic tumor burden was significantly greater in the WLR group than in the FGS group (96.92 mm2 ± SE 52.03 vs. 2.20 mm2 ± SE 1.43; respectively, χ 2 = 5.455; p = 0.02). RACPPs can accurately and effectively label pancreatic cancer for effective FGS, resulting in better postresection outcomes than for WLR surgery." @default.
• W2016050222 created "2016-06-24" @default.
• W2016050222 creator A5005803841 @default.
• W2016050222 creator A5009960666 @default.
• W2016050222 creator A5014315445 @default.
• W2016050222 creator A5040819666 @default.
• W2016050222 creator A5063672133 @default.
• W2016050222 creator A5088487350 @default.
• W2016050222 creator A5089160483 @default.
• W2016050222 creator A5091746677 @default.
• W2016050222 date "2014-10-16" @default.
• W2016050222 modified "2023-10-07" @default.
• W2016050222 title "Ratiometric Activatable Cell-Penetrating Peptides Label Pancreatic Cancer, Enabling Fluorescence-Guided Surgery, Which Reduces Metastases and Recurrence in Orthotopic Mouse Models" @default.
• W2016050222 cites W1569875761 @default.
• W2016050222 cites W1969705513 @default.
• W2016050222 cites W1975148998 @default.
• W2016050222 cites W1978498174 @default.
• W2016050222 cites W2000844719 @default.
• W2016050222 cites W2002767447 @default.
• W2016050222 cites W2017000798 @default.
• W2016050222 cites W2017349266 @default.
• W2016050222 cites W2037679647 @default.
• W2016050222 cites W2045277166 @default.
• W2016050222 cites W2047033241 @default.
• W2016050222 cites W2052406653 @default.
• W2016050222 cites W2059931622 @default.
• W2016050222 cites W2074146371 @default.
• W2016050222 cites W2084181387 @default.
• W2016050222 cites W2098384648 @default.
• W2016050222 cites W2099132605 @default.
• W2016050222 cites W2104644172 @default.
• W2016050222 cites W2112579958 @default.
• W2016050222 cites W2125372543 @default.
• W2016050222 cites W2145057519 @default.
• W2016050222 cites W2168261379 @default.
• W2016050222 cites W2168544783 @default.
• W2016050222 cites W2460048090 @default.
• W2016050222 cites W347202097 @default.
• W2016050222 doi "https://doi.org/10.1245/s10434-014-4144-1" @default.
• W2016050222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4400250" @default.
• W2016050222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25319581" @default.
• W2016050222 hasPublicationYear "2014" @default.
• W2016050222 type Work @default.
• W2016050222 sameAs 2016050222 @default.
• W2016050222 citedByCount "42" @default.
• W2016050222 countsByYear W20160502222015 @default.
• W2016050222 countsByYear W20160502222016 @default.
• W2016050222 countsByYear W20160502222017 @default.
• W2016050222 countsByYear W20160502222018 @default.
• W2016050222 countsByYear W20160502222019 @default.
• W2016050222 countsByYear W20160502222020 @default.
• W2016050222 countsByYear W20160502222021 @default.
• W2016050222 countsByYear W20160502222022 @default.
• W2016050222 crossrefType "journal-article" @default.
• W2016050222 hasAuthorship W2016050222A5005803841 @default.
• W2016050222 hasAuthorship W2016050222A5009960666 @default.
• W2016050222 hasAuthorship W2016050222A5014315445 @default.
• W2016050222 hasAuthorship W2016050222A5040819666 @default.
• W2016050222 hasAuthorship W2016050222A5063672133 @default.
• W2016050222 hasAuthorship W2016050222A5088487350 @default.
• W2016050222 hasAuthorship W2016050222A5089160483 @default.
• W2016050222 hasAuthorship W2016050222A5091746677 @default.
• W2016050222 hasBestOaLocation W20160502222 @default.
• W2016050222 hasConcept C104317684 @default.
• W2016050222 hasConcept C109523444 @default.
• W2016050222 hasConcept C121608353 @default.
• W2016050222 hasConcept C126322002 @default.
• W2016050222 hasConcept C126894567 @default.
• W2016050222 hasConcept C141071460 @default.
• W2016050222 hasConcept C142613039 @default.
• W2016050222 hasConcept C142724271 @default.
• W2016050222 hasConcept C185592680 @default.
• W2016050222 hasConcept C2780140570 @default.
• W2016050222 hasConcept C2780210213 @default.
• W2016050222 hasConcept C2989005 @default.
• W2016050222 hasConcept C55493867 @default.
• W2016050222 hasConcept C71924100 @default.
• W2016050222 hasConceptScore W2016050222C104317684 @default.
• W2016050222 hasConceptScore W2016050222C109523444 @default.
• W2016050222 hasConceptScore W2016050222C121608353 @default.
• W2016050222 hasConceptScore W2016050222C126322002 @default.
• W2016050222 hasConceptScore W2016050222C126894567 @default.
• W2016050222 hasConceptScore W2016050222C141071460 @default.
• W2016050222 hasConceptScore W2016050222C142613039 @default.
• W2016050222 hasConceptScore W2016050222C142724271 @default.
• W2016050222 hasConceptScore W2016050222C185592680 @default.
• W2016050222 hasConceptScore W2016050222C2780140570 @default.
• W2016050222 hasConceptScore W2016050222C2780210213 @default.
• W2016050222 hasConceptScore W2016050222C2989005 @default.
• W2016050222 hasConceptScore W2016050222C55493867 @default.
• W2016050222 hasConceptScore W2016050222C71924100 @default.
• W2016050222 hasIssue "6" @default.
• W2016050222 hasLocation W20160502221 @default.
• W2016050222 hasLocation W20160502222 @default.
• W2016050222 hasLocation W20160502223 @default.
• W2016050222 hasLocation W20160502224 @default.
• W2016050222 hasLocation W20160502225 @default.
• W2016050222 hasOpenAccess W2016050222 @default.

• next