FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016050368> ?p ?o ?g. }

• W2016050368 endingPage "e4947" @default.
• W2016050368 startingPage "e4947" @default.
• W2016050368 abstract "Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix. Its functional activity can be modulated by heparanase, an enzyme that cleaves heparan sulfate chains and whose expression has been associated with an aggressive phenotype in many cancers. In addition to remodeling syndecan-1 by cleaving its heparan sulfate chains, heparanase influences syndecan-1 location by upregulating expression of enzymes that accelerate its shedding from the cell surface. In the present study we discovered that heparanase also alters the level of nuclear syndecan-1. Upon upregulation of heparanase expression or following addition of recombinant heparanase to myeloma cells, the nuclear localization of syndecan-1 drops dramatically as revealed by confocal microscopy, western blotting and quantification by ELISA. This effect requires enzymatically active heparanase because cells expressing high levels of mutated, enzymatically inactive heparanase, failed to diminish syndecan-1 levels in the nucleus. Although heparan sulfate function within the nucleus is not well understood, there is emerging evidence that it may act to repress transcriptional activity. The resulting changes in gene expression facilitated by the loss of nuclear syndecan-1 could explain how heparanase enhances expression of MMP-9, VEGF, tissue factor and perhaps other effectors that condition the tumor microenvironment to promote an aggressive cancer phenotype." @default.
• W2016050368 created "2016-06-24" @default.
• W2016050368 creator A5042220394 @default.
• W2016050368 creator A5075208961 @default.
• W2016050368 date "2009-03-23" @default.
• W2016050368 modified "2023-10-12" @default.
• W2016050368 title "Heparanase Regulates Levels of Syndecan-1 in the Nucleus" @default.
• W2016050368 cites W1480795950 @default.
• W2016050368 cites W1484612874 @default.
• W2016050368 cites W1561727975 @default.
• W2016050368 cites W156547651 @default.
• W2016050368 cites W1929379028 @default.
• W2016050368 cites W1968496776 @default.
• W2016050368 cites W1970922431 @default.
• W2016050368 cites W1972892797 @default.
• W2016050368 cites W1973037169 @default.
• W2016050368 cites W1973733841 @default.
• W2016050368 cites W1975446311 @default.
• W2016050368 cites W1977877980 @default.
• W2016050368 cites W1978157514 @default.
• W2016050368 cites W1982819887 @default.
• W2016050368 cites W1998265013 @default.
• W2016050368 cites W2009962397 @default.
• W2016050368 cites W2016390124 @default.
• W2016050368 cites W2021130116 @default.
• W2016050368 cites W2027886908 @default.
• W2016050368 cites W2037813339 @default.
• W2016050368 cites W2050225501 @default.
• W2016050368 cites W2051601626 @default.
• W2016050368 cites W2052798492 @default.
• W2016050368 cites W2057877888 @default.
• W2016050368 cites W2070741299 @default.
• W2016050368 cites W2075422129 @default.
• W2016050368 cites W2118754499 @default.
• W2016050368 cites W2133458484 @default.
• W2016050368 cites W2150436360 @default.
• W2016050368 cites W2165869640 @default.
• W2016050368 cites W2167400776 @default.
• W2016050368 cites W2199761800 @default.
• W2016050368 cites W4233036449 @default.
• W2016050368 doi "https://doi.org/10.1371/journal.pone.0004947" @default.
• W2016050368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2654539" @default.
• W2016050368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19305494" @default.
• W2016050368 hasPublicationYear "2009" @default.
• W2016050368 type Work @default.
• W2016050368 sameAs 2016050368 @default.
• W2016050368 citedByCount "94" @default.
• W2016050368 countsByYear W20160503682012 @default.
• W2016050368 countsByYear W20160503682013 @default.
• W2016050368 countsByYear W20160503682014 @default.
• W2016050368 countsByYear W20160503682015 @default.
• W2016050368 countsByYear W20160503682016 @default.
• W2016050368 countsByYear W20160503682017 @default.
• W2016050368 countsByYear W20160503682018 @default.
• W2016050368 countsByYear W20160503682019 @default.
• W2016050368 countsByYear W20160503682020 @default.
• W2016050368 countsByYear W20160503682021 @default.
• W2016050368 countsByYear W20160503682022 @default.
• W2016050368 countsByYear W20160503682023 @default.
• W2016050368 crossrefType "journal-article" @default.
• W2016050368 hasAuthorship W2016050368A5042220394 @default.
• W2016050368 hasAuthorship W2016050368A5075208961 @default.
• W2016050368 hasBestOaLocation W20160503681 @default.
• W2016050368 hasConcept C104317684 @default.
• W2016050368 hasConcept C127561419 @default.
• W2016050368 hasConcept C1491633281 @default.
• W2016050368 hasConcept C153911025 @default.
• W2016050368 hasConcept C185592680 @default.
• W2016050368 hasConcept C189165786 @default.
• W2016050368 hasConcept C2777478136 @default.
• W2016050368 hasConcept C2778041096 @default.
• W2016050368 hasConcept C55493867 @default.
• W2016050368 hasConcept C65001120 @default.
• W2016050368 hasConcept C86803240 @default.
• W2016050368 hasConcept C95444343 @default.
• W2016050368 hasConceptScore W2016050368C104317684 @default.
• W2016050368 hasConceptScore W2016050368C127561419 @default.
• W2016050368 hasConceptScore W2016050368C1491633281 @default.
• W2016050368 hasConceptScore W2016050368C153911025 @default.
• W2016050368 hasConceptScore W2016050368C185592680 @default.
• W2016050368 hasConceptScore W2016050368C189165786 @default.
• W2016050368 hasConceptScore W2016050368C2777478136 @default.
• W2016050368 hasConceptScore W2016050368C2778041096 @default.
• W2016050368 hasConceptScore W2016050368C55493867 @default.
• W2016050368 hasConceptScore W2016050368C65001120 @default.
• W2016050368 hasConceptScore W2016050368C86803240 @default.
• W2016050368 hasConceptScore W2016050368C95444343 @default.
• W2016050368 hasIssue "3" @default.
• W2016050368 hasLocation W20160503681 @default.
• W2016050368 hasLocation W20160503682 @default.
• W2016050368 hasLocation W20160503683 @default.
• W2016050368 hasLocation W20160503684 @default.
• W2016050368 hasLocation W20160503685 @default.
• W2016050368 hasOpenAccess W2016050368 @default.
• W2016050368 hasPrimaryLocation W20160503681 @default.
• W2016050368 hasRelatedWork W2001535378 @default.
• W2016050368 hasRelatedWork W2012339228 @default.
• W2016050368 hasRelatedWork W2016050368 @default.

• next