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- W2016050384 abstract "Relatively little has been published on the pharmacology of R-type and T-type Ca(2+) channels. Here, whole-cell Ca(2+) channel currents were recorded from human embryonic kidney 293 cell-lines transfected with either alpha1E subunits (R-type currents) or alpha1G or alpha1I subunits (T-type currents). R-type currents were inhibited by sipatrigine and the related compound 202W92 (R-(-)-2,4-diamino-6-(fluromethyl)-5-(2,3,5-trichlorophenyl)pyrimidine) with IC(50) 10 and 56 microM, respectively. A therapeutic concentration of lamotrigine (10 microM) inhibited R-type currents (30%) but was without effect on alpha1I-mediated T-type currents. Lamotrigine was also a weak inhibitor of T-type currents mediated by alpha1G subunits (<10% inhibition by 100 microM)." @default.
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- W2016050384 date "2003-04-01" @default.
- W2016050384 modified "2023-10-17" @default.
- W2016050384 title "Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents" @default.
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- W2016050384 doi "https://doi.org/10.1016/s0014-2999(03)01625-x" @default.
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