FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016052034> ?p ?o ?g. }

• W2016052034 endingPage "170" @default.
• W2016052034 startingPage "161" @default.
• W2016052034 abstract "Summary As the absolute numbers and proportion of older adults increases across most of the developed world, a greater understanding of the aetiopathogenic mechanisms of the increased vascular risk and their therapeutic implications becomes essential to all clinicians assessing and managing the geriatric patient. The role of endothelial function and the microcirculation is increasingly recognized in the maintenance of adequate perfusion, and their dysfunction is thought to be an early and potentially reversible mechanism by which age acts to increase cardiovascular risk. Here we review evidence that altered microvascular function appears before other recognized predictors of vascular disease, and progresses from childhood to late adult life, preceding fulminant atherosclerotic or arteriosclerotic disease. Low birth-weight babies have reduced endothelial function in skin microvessels at 3 months, and by age ten brachial artery endothelial function is reduced in comparison with normal birth-weight babies. In overweight/obese adolescent children with clustering of traditional cardiovascular disease risk factors, endothelial function is lower compared with normal weight children and this appears to persist into early adulthood. Adult ageing is associated with impaired microvessel endothelial function and an increase in capillary blood pressure, independent of brachial artery blood pressure. Biological and lifestyle factors that influence microvessel function include body fat and visceral adiposity, sex hormone status, diet and physical activity. Exploration of the therapeutic implications for management of endothelial dysfunction remains in embryonic state. The use of ACE-inhibitors, angiotensin receptor blockers and direct renin inhibitors in patients with evidence of microvascular damage such as retinopathy and microalbuminuria has been established; however, in the general older population the benefit has yet to be established. Therefore current recommendations are to screen for microvascular damage and if present target treatments after control of other vascular risk factors such as hypertension." @default.
• W2016052034 created "2016-06-24" @default.
• W2016052034 creator A5033545395 @default.
• W2016052034 creator A5071927839 @default.
• W2016052034 creator A5072883388 @default.
• W2016052034 creator A5080266840 @default.
• W2016052034 date "2010-05-11" @default.
• W2016052034 modified "2023-09-28" @default.
• W2016052034 title "Age-related change in endothelial and microvessel function and therapeutic consequences" @default.
• W2016052034 cites W1519050139 @default.
• W2016052034 cites W1849785625 @default.
• W2016052034 cites W1870853477 @default.
• W2016052034 cites W1967840107 @default.
• W2016052034 cites W1970221892 @default.
• W2016052034 cites W1971066944 @default.
• W2016052034 cites W1973815850 @default.
• W2016052034 cites W1974376681 @default.
• W2016052034 cites W1976466322 @default.
• W2016052034 cites W1976788185 @default.
• W2016052034 cites W1980746058 @default.
• W2016052034 cites W1984058728 @default.
• W2016052034 cites W2000976083 @default.
• W2016052034 cites W2011277038 @default.
• W2016052034 cites W2014608570 @default.
• W2016052034 cites W2019338486 @default.
• W2016052034 cites W2022057294 @default.
• W2016052034 cites W2025627331 @default.
• W2016052034 cites W2030793158 @default.
• W2016052034 cites W2031185570 @default.
• W2016052034 cites W2033533620 @default.
• W2016052034 cites W2037365395 @default.
• W2016052034 cites W2038273086 @default.
• W2016052034 cites W2041323967 @default.
• W2016052034 cites W2042478264 @default.
• W2016052034 cites W2043618136 @default.
• W2016052034 cites W2057116025 @default.
• W2016052034 cites W2063252794 @default.
• W2016052034 cites W2065836621 @default.
• W2016052034 cites W2071680557 @default.
• W2016052034 cites W2079146383 @default.
• W2016052034 cites W2082506593 @default.
• W2016052034 cites W2083910569 @default.
• W2016052034 cites W2084533532 @default.
• W2016052034 cites W2087798038 @default.
• W2016052034 cites W2088485984 @default.
• W2016052034 cites W2093451430 @default.
• W2016052034 cites W2096308395 @default.
• W2016052034 cites W2096875294 @default.
• W2016052034 cites W2097143249 @default.
• W2016052034 cites W2100312221 @default.
• W2016052034 cites W2103828712 @default.
• W2016052034 cites W2107031719 @default.
• W2016052034 cites W2107295258 @default.
• W2016052034 cites W2110564525 @default.
• W2016052034 cites W2111286589 @default.
• W2016052034 cites W2113082835 @default.
• W2016052034 cites W2116999983 @default.
• W2016052034 cites W2118874116 @default.
• W2016052034 cites W2121065969 @default.
• W2016052034 cites W2121199934 @default.
• W2016052034 cites W2124072410 @default.
• W2016052034 cites W2124251979 @default.
• W2016052034 cites W2128451215 @default.
• W2016052034 cites W2129186954 @default.
• W2016052034 cites W2129730863 @default.
• W2016052034 cites W2131622502 @default.
• W2016052034 cites W2132440861 @default.
• W2016052034 cites W2133465800 @default.
• W2016052034 cites W2134141467 @default.
• W2016052034 cites W2136166321 @default.
• W2016052034 cites W2136242238 @default.
• W2016052034 cites W2137983259 @default.
• W2016052034 cites W2138689448 @default.
• W2016052034 cites W2139968474 @default.
• W2016052034 cites W2140047096 @default.
• W2016052034 cites W2142108077 @default.
• W2016052034 cites W2144919740 @default.
• W2016052034 cites W2145200932 @default.
• W2016052034 cites W2145632481 @default.
• W2016052034 cites W2145899271 @default.
• W2016052034 cites W2146456735 @default.
• W2016052034 cites W2147355061 @default.
• W2016052034 cites W2149734505 @default.
• W2016052034 cites W2151769456 @default.
• W2016052034 cites W2161953383 @default.
• W2016052034 cites W2166928530 @default.
• W2016052034 cites W2170401329 @default.
• W2016052034 cites W2326572543 @default.
• W2016052034 cites W2562329777 @default.
• W2016052034 cites W3021250193 @default.
• W2016052034 cites W4234722722 @default.
• W2016052034 cites W4245974534 @default.
• W2016052034 cites W4365786727 @default.
• W2016052034 cites W75021833 @default.
• W2016052034 doi "https://doi.org/10.1017/s0959259810000158" @default.
• W2016052034 hasPublicationYear "2010" @default.
• W2016052034 type Work @default.
• W2016052034 sameAs 2016052034 @default.

• next