FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016052090> ?p ?o ?g. }

• W2016052090 endingPage "72" @default.
• W2016052090 startingPage "65" @default.
• W2016052090 abstract "The pharmacological attenuation of glial activation represents a novel approach for controlling neuropathic pain, but the role of microglial and astroglial cells is not well established. To better understand the potential role of two types of glial cells, microglia and astrocytes, in the pathogenesis of neuropathic pain, we examined markers associated with them by quantitative RT-PCR, western blot and immunohistochemical analyses in the dorsal horn of the lumbar spinal cord 7days after chronic constriction injury (CCI) to the sciatic nerve in mice. The mRNA and protein of microglial cells were labeled with C1q and OX42(CD11b/c), respectively. The mRNA and protein of astrocytes were labeled with GFAP. The RT-PCR results indicated an increase in C1q mRNA that was more pronounced than the increased expression of GFAP mRNA ipsilateral to the injury in the dorsal spinal cord. Similarly, western blot and immunohistochemical analyses demonstrated an ipsilateral upregulation of OX42-positive cells (72 and 20%, respectively) and no or little (8% upregulation) change in GFAP-positive cells in the ipsilateral dorsal lumbar spinal cord. We also found that chronic intraperitoneal injection of the minocycline (microglial inhibitor) and pentoxifylline (cytokine inhibitor) attenuated CCI-induced activation of microglia, and both, but not fluorocitrate (astroglial inhibitor), diminished neuropathic pain symptoms and tactile and cold sensitivity. Our findings indicate that spinal microglia are more activated than astrocytes in peripheral injury-induced neuropathic pain. These findings implicate a glial regulation of the pain response and suggest that pharmacologically targeting microglia could effectively prevent clinical pain syndromes in programmed and/or anticipated injury." @default.
• W2016052090 created "2016-06-24" @default.
• W2016052090 creator A5003101597 @default.
• W2016052090 creator A5025654219 @default.
• W2016052090 creator A5041505362 @default.
• W2016052090 creator A5041585871 @default.
• W2016052090 creator A5067906620 @default.
• W2016052090 creator A5069011269 @default.
• W2016052090 creator A5074476887 @default.
• W2016052090 date "2009-11-01" @default.
• W2016052090 modified "2023-10-18" @default.
• W2016052090 title "Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain" @default.
• W2016052090 cites W1535641516 @default.
• W2016052090 cites W1841237986 @default.
• W2016052090 cites W1965102171 @default.
• W2016052090 cites W1966671044 @default.
• W2016052090 cites W1971063834 @default.
• W2016052090 cites W1972659294 @default.
• W2016052090 cites W1976219259 @default.
• W2016052090 cites W1979859079 @default.
• W2016052090 cites W1981014302 @default.
• W2016052090 cites W1983747933 @default.
• W2016052090 cites W1988869340 @default.
• W2016052090 cites W1990378054 @default.
• W2016052090 cites W1992206444 @default.
• W2016052090 cites W1995471440 @default.
• W2016052090 cites W1998863234 @default.
• W2016052090 cites W2000982837 @default.
• W2016052090 cites W2006050476 @default.
• W2016052090 cites W2006537861 @default.
• W2016052090 cites W2009761130 @default.
• W2016052090 cites W2012824802 @default.
• W2016052090 cites W2016448869 @default.
• W2016052090 cites W2017271614 @default.
• W2016052090 cites W2021336522 @default.
• W2016052090 cites W2022579067 @default.
• W2016052090 cites W2030568628 @default.
• W2016052090 cites W2033634651 @default.
• W2016052090 cites W2034494380 @default.
• W2016052090 cites W2039519643 @default.
• W2016052090 cites W2040088974 @default.
• W2016052090 cites W2041008164 @default.
• W2016052090 cites W2045294705 @default.
• W2016052090 cites W2046096689 @default.
• W2016052090 cites W2049593742 @default.
• W2016052090 cites W2050476288 @default.
• W2016052090 cites W2055197670 @default.
• W2016052090 cites W2058020736 @default.
• W2016052090 cites W2059522164 @default.
• W2016052090 cites W2062436855 @default.
• W2016052090 cites W2063885093 @default.
• W2016052090 cites W2065470571 @default.
• W2016052090 cites W2065686546 @default.
• W2016052090 cites W2066294954 @default.
• W2016052090 cites W2067899795 @default.
• W2016052090 cites W2067931227 @default.
• W2016052090 cites W2076783994 @default.
• W2016052090 cites W2080957703 @default.
• W2016052090 cites W2081945827 @default.
• W2016052090 cites W2082534109 @default.
• W2016052090 cites W2087454739 @default.
• W2016052090 cites W2090863733 @default.
• W2016052090 cites W2092595668 @default.
• W2016052090 cites W2093177418 @default.
• W2016052090 cites W2093738970 @default.
• W2016052090 cites W2099854799 @default.
• W2016052090 cites W2101457198 @default.
• W2016052090 cites W2113617025 @default.
• W2016052090 cites W2126112217 @default.
• W2016052090 cites W2127269510 @default.
• W2016052090 cites W2131810796 @default.
• W2016052090 cites W2138507450 @default.
• W2016052090 cites W2141180259 @default.
• W2016052090 cites W2170019750 @default.
• W2016052090 cites W2172201406 @default.
• W2016052090 doi "https://doi.org/10.1016/j.ejphar.2009.09.030" @default.
• W2016052090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19766105" @default.
• W2016052090 hasPublicationYear "2009" @default.
• W2016052090 type Work @default.
• W2016052090 sameAs 2016052090 @default.
• W2016052090 citedByCount "156" @default.
• W2016052090 countsByYear W20160520902012 @default.
• W2016052090 countsByYear W20160520902013 @default.
• W2016052090 countsByYear W20160520902014 @default.
• W2016052090 countsByYear W20160520902015 @default.
• W2016052090 countsByYear W20160520902016 @default.
• W2016052090 countsByYear W20160520902017 @default.
• W2016052090 countsByYear W20160520902018 @default.
• W2016052090 countsByYear W20160520902019 @default.
• W2016052090 countsByYear W20160520902020 @default.
• W2016052090 countsByYear W20160520902021 @default.
• W2016052090 countsByYear W20160520902022 @default.
• W2016052090 countsByYear W20160520902023 @default.
• W2016052090 crossrefType "journal-article" @default.
• W2016052090 hasAuthorship W2016052090A5003101597 @default.
• W2016052090 hasAuthorship W2016052090A5025654219 @default.
• W2016052090 hasAuthorship W2016052090A5041505362 @default.
• W2016052090 hasAuthorship W2016052090A5041585871 @default.

• next