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• W2016054154 abstract "To explore the osteogenic mechanism of nonvascular transport distraction osteogenesis (NTDO) by constructing mandibular defects in dogs.Sixty adult dogs were randomly divided into three groups with 20 dogs in each group. Canine mandibular defect models of NTDO were constructed. Animals were euthanized 1, 4 and 12 weeks after distraction, and the transport disc and surrounding tissue were collected and fixed. Histochemical staining using hematoxylin and eosin (H&E) and electron microscopic observations were used to examine bone regeneration.Distraction bone regeneration was observed in the distraction gap and around the transport disc, and osseous connections had formed between new bone and the transport disc after one week. Osteoclasts gathered around the transport disc, and bone absorption pit formation could be seen. After 4 weeks of distraction, the new bone around the transport disc was close to maturity with thick sclerostin on the middle of the transport disc. After 12 weeks the new bone and the transport disc were fully integrated, and were difficult to distinguish by H&E staining and electron microscopy.Canine mandibular defects were successfully repaired by NTDO resulting in ideal new bone formation and fully recovered mandibular physiological function. The surrounding tissues, including musculoskeletal tissues, the periosteum and other soft tissues and the nonvascular transport disc, together contribute to bone regeneration and neovascularization in NTDO." @default.
• W2016054154 created "2016-06-24" @default.
• W2016054154 creator A5028584185 @default.
• W2016054154 creator A5051198641 @default.
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• W2016054154 date "2015-01-01" @default.
• W2016054154 modified "2023-09-28" @default.
• W2016054154 title "Nonvascular transport distraction osteogenesis in bone formation and regeneration. Is it an accidental phenomenon?" @default.
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• W2016054154 doi "https://doi.org/10.1016/j.jcms.2014.10.004" @default.
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