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- W2016054305 abstract "L'adaptation des doses de théophylline per os contrôlées par la théophyllinémie a été réalisée chez 60 enfants atteints d'asthme sévère en utilisant soit une théophylline en solution aqueuse (30 cas), soit une théophylline retard (30 cas). La dose nécessaire à l'obtention d'une théophyllinémie efficace est atteinte en quatre à douze jours en atteignant une posologie variant de 11 à 30 mg/kg et par 24 heures. Ultérieurement une surveillance mensuelle de la théophyllinémie est recommandée du fait de variations, en apparence spontanées, plus importantes chez l'enfant que chez l'adulte [8]. The determination of the oral dose of theophylline, adjusted by the blood levels of theophylline, has been carried out in 60 children suffering from severe asthma by using an aqueous solution (30 cases) or a long acting preparation. The dose necessary for a satisfactory blood level was reached in 4 to 12 days with a daily dose varying from 11 to 30 mg/kg. Eventually a monthly monitoring of the blood level is recommended because of apparent spontaneous variations which are more important in children than in adults [8]." @default.
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- W2016054305 date "1981-04-01" @default.
- W2016054305 modified "2023-09-24" @default.
- W2016054305 title "Adaptation des doses de théophylline simple ou retard pour un traitement prolongé chez l'enfant" @default.
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- W2016054305 doi "https://doi.org/10.1016/s0335-7457(81)80001-9" @default.
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