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- W2016056208 abstract "19 patients of both sexes, aged 9.3 i 3.0 (X ± S.D.) years with bacteriologically confirmed typhoid orparatyphoid B fever were enrolled in this study and distributed in two treatment groups: Patients of Group I(N —1.1) received Cloramphenicol (CAP) palmitate (suspension) 50 mg/kg body weight (BW) in two daily doses;Group II patients (N—8) received CAP-crystalline (capsules) in the same doses and fiecuency of administratioaSeveral capillary blood samples were taken through twelve hours after the administration of the first dose. Freeplasma CAP was measured radioenzymatically. Pharmacokinetic parameters were calculated according to the onecompartment model. Significant differences in the plasma levels of the two pharmaceutical preparations at 30minutes (p<C0.001) were found, being higher those of crystalline CAP. Useful therapeutic concentrations wereobtained with both CAP preparations. No significant differences were found in the pharmacokinetic parameters.The clinical results were equally good with both preparations. Both CAP palmitate and crystalline base have thesame bioavailability and are suitable for the treatment of enteric fevers.(Key words: Chloramphenicol. Oral Palmitate Suspension. Crystaline. Pharmacokinetics. Typhoid Fever)." @default.
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- W2016056208 date "1986-04-01" @default.
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- W2016056208 title "Evaluación Farmacocinética en dos Formas Orales de Dosaje de Cloramfenicol en Niños con Fiebres Tíficas" @default.
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- W2016056208 doi "https://doi.org/10.4067/s0370-41061986000200001" @default.
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