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• W2016058274 abstract "We have evaluated the ability of ovalbumin to induce T-cell-specific tolerance in SJL mice. A significant decrease of interleukin 2 in lymph-node culture supernatants from tolerant mice upon antigen stimulation was seen. Oral tolerization was less effective than i.p.- or s.c.-tolerization protocols. Transfer experiments of either splenic or lymph-node T cells from tolerant mice to naive mice definitely ruled out suppression as a mechanism involved in tolerant mice. Surprisingly, we found that, before the establishment of specific T-cell tolerance to ovalbumin, T cells from mice that will display tolerance were responsive and synthesized interleukin 2 upon antigen challenge in vitro. Thus, we concluded that anergy cannot account solely for the T-cell unresponsiveness in tolerant mice. Furthermore, although we cannot rule out the hypothesis that the T-cell unresponsiveness in tolerant mice can be explained by programmed cell death of ovalbumin-specific T cells, these data led us to speculate that T-cell refractoriness could explain the drop of interleukin 2 production in lymph-node T-cell culture supernatant from tolerant mice." @default.
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• W2016058274 date "1994-06-07" @default.
• W2016058274 modified "2023-09-26" @default.
• W2016058274 title "Specific T-cell tolerance may be preceded by a primary response." @default.
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• W2016058274 doi "https://doi.org/10.1073/pnas.91.12.5627" @default.
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