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• W2016059890 abstract "The survival to term of mammalian fetuses regardless of their expression of paternal or embryonic developmental antigens suggests that some alteration in the immune capabilities of a female occur during pregnancy. The immunocompetence of female Syrian golden hamsters during pregnancy was investigated with respect to the blastogenic response of spleen cells to the T-cell mitogen concanavalin A (Con A). The blastogenic response of spleen cells from pregnant hamsters during mid- or late gestation is 10% of that observed for spleen cells from age-matched, virgin female animals. The degree of depression of Con A-induced blastogenesis is independent of the parity status of the animal, and in all parities, the normal magnitude of response to Con A returns within 10 days of parturition. The concentration of Con A required for maximal stimulation is unaffected by the state of pregnancy. The spleen cells from pregnant hamsters are not capable of suppressing the proliferative response of spleen cells from virgin females to Con A. However, the serum from pregnant hamsters, in comparison with serum from virgin female animals, is capable of reducing this mitogenic response. Extensive washing of the splenocytes from pregnant hamsters does reduce the degree of suppression. These results suggest that the hamster is an excellent animal model for the investigation of the mechanism(s) of immune regulation that operate during pregnancy." @default.
• W2016059890 created "2016-06-24" @default.
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• W2016059890 date "1980-08-01" @default.
• W2016059890 modified "2023-09-23" @default.
• W2016059890 title "Regulation of hamster splenocyte reactivity to concanavalin a during pregnancy" @default.
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• W2016059890 doi "https://doi.org/10.1016/0008-8749(80)90201-4" @default.
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