FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016060470> ?p ?o ?g. }

• W2016060470 endingPage "171" @default.
• W2016060470 startingPage "164" @default.
• W2016060470 abstract "β-arrestin 1 and 2 (also known as arrestin 2 and 3) are homologous adaptor proteins that regulate seven-transmembrane receptor trafficking and signalling. Other proteins with predicted 'arrestin-like' structural domains but lacking sequence homology have been indicated to function like β-arrestin in receptor regulation. We demonstrate that β-arrestin2 is the primary adaptor that rapidly binds agonist-activated β(2) adrenergic receptors (β(2)ARs) and promotes clathrin-dependent internalization, E3 ligase Nedd4 recruitment and ubiquitin-dependent lysosomal degradation of the receptor. The arrestin-domain-containing (ARRDC) proteins 2, 3 and 4 are secondary adaptors recruited to internalized β(2)AR-Nedd4 complexes on endosomes and do not affect the adaptor roles of β-arrestin2. Rather, the role of ARRDC proteins is to traffic Nedd4-β(2)AR complexes to a subpopulation of early endosomes." @default.
• W2016060470 created "2016-06-24" @default.
• W2016060470 creator A5016396161 @default.
• W2016060470 creator A5063246729 @default.
• W2016060470 creator A5083173744 @default.
• W2016060470 date "2012-12-04" @default.
• W2016060470 modified "2023-10-13" @default.
• W2016060470 title "Distinct roles for β‐arrestin2 and arrestin‐domain‐containing proteins in β ₂ adrenergic receptor trafficking" @default.
• W2016060470 cites W1987038656 @default.
• W2016060470 cites W1994539207 @default.
• W2016060470 cites W2003113804 @default.
• W2016060470 cites W2003609221 @default.
• W2016060470 cites W2008272668 @default.
• W2016060470 cites W2025472785 @default.
• W2016060470 cites W2025569306 @default.
• W2016060470 cites W2027030905 @default.
• W2016060470 cites W2027832797 @default.
• W2016060470 cites W2029000864 @default.
• W2016060470 cites W2030222651 @default.
• W2016060470 cites W2030854565 @default.
• W2016060470 cites W2047703003 @default.
• W2016060470 cites W2048669565 @default.
• W2016060470 cites W2049004084 @default.
• W2016060470 cites W2053476250 @default.
• W2016060470 cites W2058334083 @default.
• W2016060470 cites W2059960663 @default.
• W2016060470 cites W2078835223 @default.
• W2016060470 cites W2091073917 @default.
• W2016060470 cites W2091366475 @default.
• W2016060470 cites W2096986888 @default.
• W2016060470 cites W2108934064 @default.
• W2016060470 cites W2118579624 @default.
• W2016060470 cites W2119398013 @default.
• W2016060470 cites W2128764621 @default.
• W2016060470 cites W2135319033 @default.
• W2016060470 cites W2139073905 @default.
• W2016060470 cites W2157972644 @default.
• W2016060470 cites W2165488941 @default.
• W2016060470 doi "https://doi.org/10.1038/embor.2012.187" @default.
• W2016060470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3596129" @default.
• W2016060470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23208550" @default.
• W2016060470 hasPublicationYear "2012" @default.
• W2016060470 type Work @default.
• W2016060470 sameAs 2016060470 @default.
• W2016060470 citedByCount "100" @default.
• W2016060470 countsByYear W20160604702013 @default.
• W2016060470 countsByYear W20160604702014 @default.
• W2016060470 countsByYear W20160604702015 @default.
• W2016060470 countsByYear W20160604702016 @default.
• W2016060470 countsByYear W20160604702017 @default.
• W2016060470 countsByYear W20160604702018 @default.
• W2016060470 countsByYear W20160604702019 @default.
• W2016060470 countsByYear W20160604702020 @default.
• W2016060470 countsByYear W20160604702021 @default.
• W2016060470 countsByYear W20160604702022 @default.
• W2016060470 countsByYear W20160604702023 @default.
• W2016060470 crossrefType "journal-article" @default.
• W2016060470 hasAuthorship W2016060470A5016396161 @default.
• W2016060470 hasAuthorship W2016060470A5063246729 @default.
• W2016060470 hasAuthorship W2016060470A5083173744 @default.
• W2016060470 hasBestOaLocation W20160604702 @default.
• W2016060470 hasConcept C102747710 @default.
• W2016060470 hasConcept C104317684 @default.
• W2016060470 hasConcept C134459356 @default.
• W2016060470 hasConcept C135285700 @default.
• W2016060470 hasConcept C139770010 @default.
• W2016060470 hasConcept C170493617 @default.
• W2016060470 hasConcept C183786373 @default.
• W2016060470 hasConcept C185592680 @default.
• W2016060470 hasConcept C25602115 @default.
• W2016060470 hasConcept C2777265272 @default.
• W2016060470 hasConcept C2777503648 @default.
• W2016060470 hasConcept C28005876 @default.
• W2016060470 hasConcept C55493867 @default.
• W2016060470 hasConcept C62478195 @default.
• W2016060470 hasConcept C63162447 @default.
• W2016060470 hasConcept C79747257 @default.
• W2016060470 hasConcept C79879829 @default.
• W2016060470 hasConcept C86803240 @default.
• W2016060470 hasConcept C95444343 @default.
• W2016060470 hasConceptScore W2016060470C102747710 @default.
• W2016060470 hasConceptScore W2016060470C104317684 @default.
• W2016060470 hasConceptScore W2016060470C134459356 @default.
• W2016060470 hasConceptScore W2016060470C135285700 @default.
• W2016060470 hasConceptScore W2016060470C139770010 @default.
• W2016060470 hasConceptScore W2016060470C170493617 @default.
• W2016060470 hasConceptScore W2016060470C183786373 @default.
• W2016060470 hasConceptScore W2016060470C185592680 @default.
• W2016060470 hasConceptScore W2016060470C25602115 @default.
• W2016060470 hasConceptScore W2016060470C2777265272 @default.
• W2016060470 hasConceptScore W2016060470C2777503648 @default.
• W2016060470 hasConceptScore W2016060470C28005876 @default.
• W2016060470 hasConceptScore W2016060470C55493867 @default.
• W2016060470 hasConceptScore W2016060470C62478195 @default.
• W2016060470 hasConceptScore W2016060470C63162447 @default.
• W2016060470 hasConceptScore W2016060470C79747257 @default.
• W2016060470 hasConceptScore W2016060470C79879829 @default.
• W2016060470 hasConceptScore W2016060470C86803240 @default.

• next