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• W2016062514 abstract "Scalaradial (SLD), a marine natural product isolated from the sponge (Cacospongia sp., possesses anti-inflammatory properties in vivo and in vitro (Pharmacologist 32: 168, 1990). In this study we characterize its effects against bee venom phospholipase A2 (PLA2; EC 3.1.1.4). SLD is a potent inactivator of bee venom PLA2 with an IC50 value of 0.07 microM. Inactivation of bee venom PLA2 occurred in a time-dependent, irreversible manner. The rate of inactivation followed first-order reaction kinetics and was dependent on the concentration of SLD. Kinetic analysis suggested a two-step mechanism of inactivation: an initial apparent noncovalent binding (Ki = 4.5 x 10(-5) M) followed by covalent modification. The rate of inactivation was reduced markedly in the presence of excess phosphatidylcholine, suggesting that modification of the enzyme occurs at or near the substrate binding site." @default.
• W2016062514 created "2016-06-24" @default.
• W2016062514 creator A5034753390 @default.
• W2016062514 creator A5059198554 @default.
• W2016062514 date "1991-09-01" @default.
• W2016062514 modified "2023-10-14" @default.
• W2016062514 title "Two-step inactivation of bee venom phospholipase A2 by scalaradial" @default.
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• W2016062514 doi "https://doi.org/10.1016/0006-2952(91)90432-5" @default.
• W2016062514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1930288" @default.
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