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• W2016064248 abstract "We undertook a kinetic analysis of the generation of mature T cells in TCR and coreceptor transgenic mice using BrdU labeling. We observed that the selection efficiency of mature CD4-CD8+ and CD4+CD8- thymocytes could be as high as 40% and 90% of CD4+CD8+ precursors, respectively. The surprisingly high efficiency of selection favors an instructional model of lineage commitment and is incompatible with a stochastic model in which the efficiency of selection would be no greater than 100% in both lineages combined." @default.
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• W2016064248 modified "2023-09-24" @default.
• W2016064248 title "Highly Efficient Selection of CD4 and CD8 Lineage Thymocytes Supports an Instructive Model of Lineage Commitment" @default.
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• W2016064248 doi "https://doi.org/10.1016/s1074-7613(00)80190-9" @default.
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