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• W2016065812 abstract "Naive T cells can be induced to differentiate from an uncommitted precursor to T helper 1 (Thl ) and Th2 cells. During this differentiation, genes for transcription factors are activated, and transcription factors such as AP-1 accumulate. To study this activation, we have developed reporter transgenic mice for a number of factors, including AP-1. Naive T cells require two signals to activate AP-1. However, upon becoming effector cells, activation through diacylglycerol analogues is sufficient. Rested effector cells lose accumulated AP-1, and the induction of AP-1 synthesis requires both Ca2+ diacylglycerol signals, but not co-stimulation." @default.
• W2016065812 created "2016-06-24" @default.
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• W2016065812 date "2007-09-28" @default.
• W2016065812 modified "2023-10-18" @default.
• W2016065812 title "Regulation of CD4+ T Cell Differentiation" @default.
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• W2016065812 doi "https://doi.org/10.1002/9780470514849.ch11" @default.
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