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• W2016065995 abstract "We have previously demonstrated a marked loss in N-methyl-d-aspartate (NMDA) receptors in the hippocampus and cerebral cortex of patients dying with dementia of the Alzheimer type (DAT). In addition, we have found that the dissociative anesthetic N-(1-[2-thienyl]cyclohexyl)3,4-piperidine ([3H]TCP) binds to a site whose regional distribution is highly correlated with that of NMDA receptor sites. We studied the binding of [3H]TCP to sections of hippocampi from 8 controls, 12 patients with DAT and 7 patients with other dementias. [3H]TCP binding was significantly reduced in strata pyramidalia of CA1/CA2, CA3 and subiculum of DAT hippocampal formation compared to that of control. Labelled dissociative anestheties could potentially be used with positron emission tomography in the diagnosis of DAT." @default.
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• W2016065995 date "1987-03-01" @default.
• W2016065995 modified "2023-10-18" @default.
• W2016065995 title "Loss of hippocampal [3H]TCP binding in Alzheimer's disease" @default.
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• W2016065995 doi "https://doi.org/10.1016/0304-3940(87)90326-0" @default.
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