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• W2016066013 abstract "ISEE-495 Introduction: To investigate the association of Parkinson’s disease (PD) with occupational exposures using a case-control study design. Methods: We used the medical records-linkage system of the Rochester Epidemiology Project to identify subjects who developed PD in Olmsted County, MN from 1976 through 1995. Each incident case was matched by age (+/− 1 year) and sex to a general population control. For cases and controls, we collected information about all occupations held for more than one year and preceding the onset of PD using both a review of the complete medical records in the system and a direct or proxy telephone interview. We investigated the association of PD with occupational groups as per the Standard Occupational Classification (SOC), and with occupations possibly related to toxic or infectious exposures. Results: Information from medical records abstracting was available for 196 cases and 196 controls. Information from telephone interview was available for 149 cases (49 direct and 100 proxy) and 129 controls (63 direct and 66 proxy). We found consistent results from the two sources of exposure information for the majority of job groups considered. Physicians were at significantly increased risk of PD (odds ratio [OR] = 3.7; 95% CI = 1.0 to 13.1 using the medical records data and OR = 10.1; 95% CI = 1.2 to 82.0 using the telephone interview data). Among the 11 physicians with PD, there were 3 generalists, 2 surgeons, and 6 specialists (from 6 distinct specialties). Three SOC groups showed an inverse association with PD using one exposure source but not the other (construction and extractive workers, production workers, and metal workers). Farmers and agricultural workers were not at increased risk of PD in this population (OR = 1.1; 95% CI = 0.6 to 1.9 using the medical records data and OR = 1.2; 95% CI = 0.7 to 2.2 using the telephone interview data). We did not find any associations with other occupations possibly related to toxic exposure or infectious exposures. Discussion: Our results suggest that physicians are the only occupational group with an increased risk of PD. We cannot exclude that this association is partly explained by a surveillance bias (earlier detection of PD in physicians). However, the time lag between onset of symptoms and diagnosis was similar among physicians and non-physicians. We did not confirm the association of PD with farming in this population." @default.
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• W2016066013 date "2004-07-01" @default.
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• W2016066013 title "OCCUPATIONAL EXPOSURES AND PARKINSON’S DISEASE: A POPULATION-BASED, CASE-CONTROL STUDY" @default.
• W2016066013 doi "https://doi.org/10.1097/00001648-200407000-00518" @default.
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