Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016066896> ?p ?o ?g. }
- W2016066896 endingPage "98" @default.
- W2016066896 startingPage "89" @default.
- W2016066896 abstract "The effect of Kupffer cells on natural killer (NK) cell-mediated cytotoxicity was examined. Kupffer cells prepared from rat liver suppressed NK activity against K562 cells and other tumor cell lines through a soluble factor secreted into the culture supernatant. When human peripheral blood mononuclear cells were incubated with the Kupffer cell-culture supernatant, a significant reduction of the cytotoxic activity was observed in the 6-hr chromium-release assay. This activity was dose dependent and was evident at various effector/target cell ratios. Lipopolysaccharide stimulated generation of the suppressive factor released from Kupffer cells in a dose-dependent manner. Suppression of the NK activity was observed when the Kupffer cell-culture supernatant was present in the assay system, whereas pretreatment of effector/target cells with the supernatant had minimal inhibitory effects. Autologous monocytes in human peripheral mononuclear cells were not related to this suppression. The suppressive factor in the fraction had a molecular weight below 10,000. Indomethacin, an inhibitor of prostaglandin synthesis, ameliorated the suppressive effects. These results suggest that Kupffer cells may modulate NK activity by producing PGs (E1, E2, and F2α)." @default.
- W2016066896 created "2016-06-24" @default.
- W2016066896 creator A5007947253 @default.
- W2016066896 creator A5008027813 @default.
- W2016066896 creator A5019835015 @default.
- W2016066896 creator A5027437511 @default.
- W2016066896 creator A5051843684 @default.
- W2016066896 creator A5059642047 @default.
- W2016066896 creator A5075720321 @default.
- W2016066896 date "1987-06-01" @default.
- W2016066896 modified "2023-09-27" @default.
- W2016066896 title "Kupffer cells modulate natural killer cell activity in vitro by producing prostaglandins" @default.
- W2016066896 cites W1482804511 @default.
- W2016066896 cites W1502266768 @default.
- W2016066896 cites W1512164373 @default.
- W2016066896 cites W1519444595 @default.
- W2016066896 cites W1550686374 @default.
- W2016066896 cites W1554161798 @default.
- W2016066896 cites W1563827978 @default.
- W2016066896 cites W1574461901 @default.
- W2016066896 cites W1605611339 @default.
- W2016066896 cites W1677638125 @default.
- W2016066896 cites W1755086614 @default.
- W2016066896 cites W1779184714 @default.
- W2016066896 cites W1804866898 @default.
- W2016066896 cites W1920140886 @default.
- W2016066896 cites W1971500444 @default.
- W2016066896 cites W1974469534 @default.
- W2016066896 cites W1981684603 @default.
- W2016066896 cites W1987700142 @default.
- W2016066896 cites W1994591447 @default.
- W2016066896 cites W1998773202 @default.
- W2016066896 cites W2015708927 @default.
- W2016066896 cites W2022899050 @default.
- W2016066896 cites W2023840999 @default.
- W2016066896 cites W2025634075 @default.
- W2016066896 cites W2026822339 @default.
- W2016066896 cites W2051918741 @default.
- W2016066896 cites W2073201889 @default.
- W2016066896 cites W2079991918 @default.
- W2016066896 cites W2092317194 @default.
- W2016066896 cites W2094003620 @default.
- W2016066896 cites W2094729119 @default.
- W2016066896 cites W2101970353 @default.
- W2016066896 cites W2106059483 @default.
- W2016066896 cites W2126189428 @default.
- W2016066896 cites W2145558217 @default.
- W2016066896 cites W2259678527 @default.
- W2016066896 cites W4313310658 @default.
- W2016066896 doi "https://doi.org/10.1016/0008-8749(87)90268-1" @default.
- W2016066896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3581176" @default.
- W2016066896 hasPublicationYear "1987" @default.
- W2016066896 type Work @default.
- W2016066896 sameAs 2016066896 @default.
- W2016066896 citedByCount "27" @default.
- W2016066896 countsByYear W20160668962012 @default.
- W2016066896 crossrefType "journal-article" @default.
- W2016066896 hasAuthorship W2016066896A5007947253 @default.
- W2016066896 hasAuthorship W2016066896A5008027813 @default.
- W2016066896 hasAuthorship W2016066896A5019835015 @default.
- W2016066896 hasAuthorship W2016066896A5027437511 @default.
- W2016066896 hasAuthorship W2016066896A5051843684 @default.
- W2016066896 hasAuthorship W2016066896A5059642047 @default.
- W2016066896 hasAuthorship W2016066896A5075720321 @default.
- W2016066896 hasConcept C109316439 @default.
- W2016066896 hasConcept C134018914 @default.
- W2016066896 hasConcept C137061746 @default.
- W2016066896 hasConcept C1491633281 @default.
- W2016066896 hasConcept C149532602 @default.
- W2016066896 hasConcept C153911025 @default.
- W2016066896 hasConcept C154317977 @default.
- W2016066896 hasConcept C171122931 @default.
- W2016066896 hasConcept C202751555 @default.
- W2016066896 hasConcept C203014093 @default.
- W2016066896 hasConcept C2777198256 @default.
- W2016066896 hasConcept C2778102761 @default.
- W2016066896 hasConcept C2778904781 @default.
- W2016066896 hasConcept C28651165 @default.
- W2016066896 hasConcept C49039625 @default.
- W2016066896 hasConcept C51785407 @default.
- W2016066896 hasConcept C54355233 @default.
- W2016066896 hasConcept C55493867 @default.
- W2016066896 hasConcept C81885089 @default.
- W2016066896 hasConcept C86803240 @default.
- W2016066896 hasConcept C95444343 @default.
- W2016066896 hasConceptScore W2016066896C109316439 @default.
- W2016066896 hasConceptScore W2016066896C134018914 @default.
- W2016066896 hasConceptScore W2016066896C137061746 @default.
- W2016066896 hasConceptScore W2016066896C1491633281 @default.
- W2016066896 hasConceptScore W2016066896C149532602 @default.
- W2016066896 hasConceptScore W2016066896C153911025 @default.
- W2016066896 hasConceptScore W2016066896C154317977 @default.
- W2016066896 hasConceptScore W2016066896C171122931 @default.
- W2016066896 hasConceptScore W2016066896C202751555 @default.
- W2016066896 hasConceptScore W2016066896C203014093 @default.
- W2016066896 hasConceptScore W2016066896C2777198256 @default.
- W2016066896 hasConceptScore W2016066896C2778102761 @default.
- W2016066896 hasConceptScore W2016066896C2778904781 @default.