Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016067897> ?p ?o ?g. }
- W2016067897 endingPage "1152" @default.
- W2016067897 startingPage "1144" @default.
- W2016067897 abstract "The ErbB receptor family has been implicated in brain metastases (BM) formation in various cancer types and specific targeted therapies are available. We investigated the overexpression of EGFR, HER2 and HER3 in BM of non-small cell lung cancer (NSCLC) patients to get a better insight on pathobiology of BM and potential drugable targets. We performed immunohistochemical analysis of EGFR, HER2 and HER3 on tissue microarrays of 131 NSCLC-BM. Fifty-one of 131 (38.9%) specimens were considered as positive for EGFR overexpression, 12/131 (9.2%) for HER2 and 27/131 (20.6%) for HER3 respectively. Sixty-nine of 131 (52.7%) of the cases showed overexpression of at least one marker. Four of 131 (3.1%) were positive for all three markers. Strong correlation was observed between HER2 and HER3 overexpression (p = 0.009; Chi-square test after Bonferroni-Holmes correction). No statistically significant correlation of EGFR, HER2 or HER3 overexpression with clinico-pathological parameters including overall survival times was observed. We observed overexpression of ErbB receptor family members, which represent established therapeutic targets in various primary tumours, in approximately half of NSCLC-BM. Further studies should investigate the role of the ErbB pathway in development of and as a therapeutic target in BM of NSCLC patients." @default.
- W2016067897 created "2016-06-24" @default.
- W2016067897 creator A5001781588 @default.
- W2016067897 creator A5004114090 @default.
- W2016067897 creator A5005818602 @default.
- W2016067897 creator A5015650022 @default.
- W2016067897 creator A5017210624 @default.
- W2016067897 creator A5025877193 @default.
- W2016067897 creator A5028667261 @default.
- W2016067897 creator A5036883323 @default.
- W2016067897 creator A5053746026 @default.
- W2016067897 creator A5057141936 @default.
- W2016067897 creator A5062119624 @default.
- W2016067897 creator A5064983617 @default.
- W2016067897 date "2013-06-12" @default.
- W2016067897 modified "2023-09-27" @default.
- W2016067897 title "Frequent overexpression of ErbB - receptor family members in brain metastases of non-small cell lung cancer patients" @default.
- W2016067897 cites W1533487512 @default.
- W2016067897 cites W1762294177 @default.
- W2016067897 cites W1967005016 @default.
- W2016067897 cites W1970476748 @default.
- W2016067897 cites W1972202167 @default.
- W2016067897 cites W1972870283 @default.
- W2016067897 cites W1974820090 @default.
- W2016067897 cites W1975775723 @default.
- W2016067897 cites W2017215174 @default.
- W2016067897 cites W2023673693 @default.
- W2016067897 cites W2024772577 @default.
- W2016067897 cites W2031659472 @default.
- W2016067897 cites W2035982498 @default.
- W2016067897 cites W2062778062 @default.
- W2016067897 cites W2072077210 @default.
- W2016067897 cites W2078068853 @default.
- W2016067897 cites W2081740550 @default.
- W2016067897 cites W2087810003 @default.
- W2016067897 cites W2089588020 @default.
- W2016067897 cites W2098785500 @default.
- W2016067897 cites W2100439220 @default.
- W2016067897 cites W2114060414 @default.
- W2016067897 cites W2115091425 @default.
- W2016067897 cites W2118221532 @default.
- W2016067897 cites W2128601644 @default.
- W2016067897 cites W2130327416 @default.
- W2016067897 cites W2133208325 @default.
- W2016067897 cites W2145640226 @default.
- W2016067897 cites W2147840374 @default.
- W2016067897 cites W2155894313 @default.
- W2016067897 cites W2165948908 @default.
- W2016067897 doi "https://doi.org/10.1111/apm.12063" @default.
- W2016067897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23756255" @default.
- W2016067897 hasPublicationYear "2013" @default.
- W2016067897 type Work @default.
- W2016067897 sameAs 2016067897 @default.
- W2016067897 citedByCount "14" @default.
- W2016067897 countsByYear W20160678972014 @default.
- W2016067897 countsByYear W20160678972015 @default.
- W2016067897 countsByYear W20160678972016 @default.
- W2016067897 countsByYear W20160678972017 @default.
- W2016067897 countsByYear W20160678972019 @default.
- W2016067897 countsByYear W20160678972020 @default.
- W2016067897 countsByYear W20160678972021 @default.
- W2016067897 countsByYear W20160678972022 @default.
- W2016067897 crossrefType "journal-article" @default.
- W2016067897 hasAuthorship W2016067897A5001781588 @default.
- W2016067897 hasAuthorship W2016067897A5004114090 @default.
- W2016067897 hasAuthorship W2016067897A5005818602 @default.
- W2016067897 hasAuthorship W2016067897A5015650022 @default.
- W2016067897 hasAuthorship W2016067897A5017210624 @default.
- W2016067897 hasAuthorship W2016067897A5025877193 @default.
- W2016067897 hasAuthorship W2016067897A5028667261 @default.
- W2016067897 hasAuthorship W2016067897A5036883323 @default.
- W2016067897 hasAuthorship W2016067897A5053746026 @default.
- W2016067897 hasAuthorship W2016067897A5057141936 @default.
- W2016067897 hasAuthorship W2016067897A5062119624 @default.
- W2016067897 hasAuthorship W2016067897A5064983617 @default.
- W2016067897 hasConcept C121608353 @default.
- W2016067897 hasConcept C126322002 @default.
- W2016067897 hasConcept C142724271 @default.
- W2016067897 hasConcept C143998085 @default.
- W2016067897 hasConcept C170493617 @default.
- W2016067897 hasConcept C193270364 @default.
- W2016067897 hasConcept C204232928 @default.
- W2016067897 hasConcept C207886595 @default.
- W2016067897 hasConcept C2776256026 @default.
- W2016067897 hasConcept C2777714996 @default.
- W2016067897 hasConcept C2779251935 @default.
- W2016067897 hasConcept C502942594 @default.
- W2016067897 hasConcept C71924100 @default.
- W2016067897 hasConceptScore W2016067897C121608353 @default.
- W2016067897 hasConceptScore W2016067897C126322002 @default.
- W2016067897 hasConceptScore W2016067897C142724271 @default.
- W2016067897 hasConceptScore W2016067897C143998085 @default.
- W2016067897 hasConceptScore W2016067897C170493617 @default.
- W2016067897 hasConceptScore W2016067897C193270364 @default.
- W2016067897 hasConceptScore W2016067897C204232928 @default.
- W2016067897 hasConceptScore W2016067897C207886595 @default.
- W2016067897 hasConceptScore W2016067897C2776256026 @default.
- W2016067897 hasConceptScore W2016067897C2777714996 @default.