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• W2016069807 endingPage "e1287" @default.
• W2016069807 startingPage "e1287" @default.
• W2016069807 abstract "The three sub-species of Trypanosoma brucei are important pathogens of sub-Saharan Africa. T. b. brucei is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. T. b. rhodesiense and T. b. gambiense are able to resist lysis by TLF. There are two distinct sub-groups of T. b. gambiense that differ genetically and by human serum resistance phenotypes. Group 1 T. b. gambiense have an invariant phenotype whereas group 2 show variable resistance. Previous data indicated that group 1 T. b. gambiense are resistant to TLF-1 due in-part to reduced uptake of TLF-1 mediated by reduced expression of the TLF-1 receptor (the haptoglobin-hemoglobin receptor (HpHbR)) gene. Here we investigate if this is also true in group 2 parasites.Isogenic resistant and sensitive group 2 T. b. gambiense were derived and compared to other T. brucei parasites. Both resistant and sensitive lines express the HpHbR gene at similar levels and internalized fluorescently labeled TLF-1 similar fashion to T. b. brucei. Both resistant and sensitive group 2, as well as group 1 T. b. gambiense, internalize recombinant APOL1, but only sensitive group 2 parasites are lysed.Our data indicate that, despite group 1 T. b. gambiense avoiding TLF-1, it is resistant to the main lytic component, APOL1. Similarly group 2 T. b. gambiense is innately resistant to APOL1, which could be based on the same mechanism. However, group 2 T. b. gambiense variably displays this phenotype and expression does not appear to correlate with a change in expression site or expression of HpHbR. Thus there are differences in the mechanism of human serum resistance between T. b. gambiense groups 1 and 2." @default.
• W2016069807 created "2016-06-24" @default.
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• W2016069807 creator A5084134156 @default.
• W2016069807 date "2011-09-06" @default.
• W2016069807 modified "2023-09-26" @default.
• W2016069807 title "Differences between Trypanosoma brucei gambiense Groups 1 and 2 in Their Resistance to Killing by Trypanolytic Factor 1" @default.
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• W2016069807 doi "https://doi.org/10.1371/journal.pntd.0001287" @default.
• W2016069807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3167774" @default.
• W2016069807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21909441" @default.
• W2016069807 hasPublicationYear "2011" @default.
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