Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016069829> ?p ?o ?g. }
- W2016069829 endingPage "13947" @default.
- W2016069829 startingPage "13937" @default.
- W2016069829 abstract "Rapid changes in cell volume characterize macrophage activation, but the role of water channels in inflammation remains unclear. We show here that, in vitro, aquaporin (AQP) blockade or deficiency results in reduced IL-1β release by macrophages activated with a variety of NLRP3 activators. Inhibition of AQP specifically during the regulatory volume decrease process is sufficient to limit IL-1β release by macrophages through the NLRP3 inflammasome axis. The immune-related activity of AQP was confirmed in vivo in a model of acute lung inflammation induced by crystals. AQP1 deficiency is associated with a marked reduction of both lung IL-1β release and neutrophilic inflammation. We conclude that AQP-mediated water transport in macrophages constitutes a general danger signal required for NLRP3-related inflammation. Our findings reveal a new function of AQP in the inflammatory process and suggest a novel therapeutic target for anti-inflammatory therapy. Rapid changes in cell volume characterize macrophage activation, but the role of water channels in inflammation remains unclear. We show here that, in vitro, aquaporin (AQP) blockade or deficiency results in reduced IL-1β release by macrophages activated with a variety of NLRP3 activators. Inhibition of AQP specifically during the regulatory volume decrease process is sufficient to limit IL-1β release by macrophages through the NLRP3 inflammasome axis. The immune-related activity of AQP was confirmed in vivo in a model of acute lung inflammation induced by crystals. AQP1 deficiency is associated with a marked reduction of both lung IL-1β release and neutrophilic inflammation. We conclude that AQP-mediated water transport in macrophages constitutes a general danger signal required for NLRP3-related inflammation. Our findings reveal a new function of AQP in the inflammatory process and suggest a novel therapeutic target for anti-inflammatory therapy." @default.
- W2016069829 created "2016-06-24" @default.
- W2016069829 creator A5003715910 @default.
- W2016069829 creator A5009742767 @default.
- W2016069829 creator A5027204791 @default.
- W2016069829 creator A5030358123 @default.
- W2016069829 creator A5032386621 @default.
- W2016069829 creator A5032680309 @default.
- W2016069829 creator A5033792420 @default.
- W2016069829 creator A5039069579 @default.
- W2016069829 creator A5064346970 @default.
- W2016069829 creator A5068749565 @default.
- W2016069829 creator A5082873920 @default.
- W2016069829 creator A5083161591 @default.
- W2016069829 date "2014-05-01" @default.
- W2016069829 modified "2023-10-17" @default.
- W2016069829 title "Critical Role of Aquaporins in Interleukin 1β (IL-1β)-induced Inflammation" @default.
- W2016069829 cites W1680053970 @default.
- W2016069829 cites W1972348350 @default.
- W2016069829 cites W1975296966 @default.
- W2016069829 cites W1981013578 @default.
- W2016069829 cites W1984284559 @default.
- W2016069829 cites W1989707197 @default.
- W2016069829 cites W1990560000 @default.
- W2016069829 cites W1996387393 @default.
- W2016069829 cites W2001079584 @default.
- W2016069829 cites W2005417769 @default.
- W2016069829 cites W2009004909 @default.
- W2016069829 cites W2013471060 @default.
- W2016069829 cites W2024171691 @default.
- W2016069829 cites W2026950841 @default.
- W2016069829 cites W2029342850 @default.
- W2016069829 cites W2032704948 @default.
- W2016069829 cites W2045365811 @default.
- W2016069829 cites W2045790003 @default.
- W2016069829 cites W2045887134 @default.
- W2016069829 cites W2048788248 @default.
- W2016069829 cites W2049230124 @default.
- W2016069829 cites W2051206939 @default.
- W2016069829 cites W2061540394 @default.
- W2016069829 cites W2067190952 @default.
- W2016069829 cites W2067814837 @default.
- W2016069829 cites W2073716580 @default.
- W2016069829 cites W2076063079 @default.
- W2016069829 cites W2078840632 @default.
- W2016069829 cites W2079882002 @default.
- W2016069829 cites W2080572190 @default.
- W2016069829 cites W2094444020 @default.
- W2016069829 cites W2098780311 @default.
- W2016069829 cites W2099806775 @default.
- W2016069829 cites W2101015806 @default.
- W2016069829 cites W2108066317 @default.
- W2016069829 cites W2121454052 @default.
- W2016069829 cites W2124178650 @default.
- W2016069829 cites W2125241840 @default.
- W2016069829 cites W2126384811 @default.
- W2016069829 cites W2127302126 @default.
- W2016069829 cites W2128056463 @default.
- W2016069829 cites W2129500302 @default.
- W2016069829 cites W2141286193 @default.
- W2016069829 cites W2141331384 @default.
- W2016069829 cites W2147208800 @default.
- W2016069829 cites W2155582127 @default.
- W2016069829 cites W2168428983 @default.
- W2016069829 doi "https://doi.org/10.1074/jbc.m113.534594" @default.
- W2016069829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4022865" @default.
- W2016069829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24700466" @default.
- W2016069829 hasPublicationYear "2014" @default.
- W2016069829 type Work @default.
- W2016069829 sameAs 2016069829 @default.
- W2016069829 citedByCount "56" @default.
- W2016069829 countsByYear W20160698292014 @default.
- W2016069829 countsByYear W20160698292015 @default.
- W2016069829 countsByYear W20160698292016 @default.
- W2016069829 countsByYear W20160698292017 @default.
- W2016069829 countsByYear W20160698292018 @default.
- W2016069829 countsByYear W20160698292019 @default.
- W2016069829 countsByYear W20160698292020 @default.
- W2016069829 countsByYear W20160698292021 @default.
- W2016069829 countsByYear W20160698292022 @default.
- W2016069829 countsByYear W20160698292023 @default.
- W2016069829 crossrefType "journal-article" @default.
- W2016069829 hasAuthorship W2016069829A5003715910 @default.
- W2016069829 hasAuthorship W2016069829A5009742767 @default.
- W2016069829 hasAuthorship W2016069829A5027204791 @default.
- W2016069829 hasAuthorship W2016069829A5030358123 @default.
- W2016069829 hasAuthorship W2016069829A5032386621 @default.
- W2016069829 hasAuthorship W2016069829A5032680309 @default.
- W2016069829 hasAuthorship W2016069829A5033792420 @default.
- W2016069829 hasAuthorship W2016069829A5039069579 @default.
- W2016069829 hasAuthorship W2016069829A5064346970 @default.
- W2016069829 hasAuthorship W2016069829A5068749565 @default.
- W2016069829 hasAuthorship W2016069829A5082873920 @default.
- W2016069829 hasAuthorship W2016069829A5083161591 @default.
- W2016069829 hasBestOaLocation W20160698291 @default.
- W2016069829 hasConcept C150903083 @default.
- W2016069829 hasConcept C185592680 @default.
- W2016069829 hasConcept C202751555 @default.