FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016070017> ?p ?o ?g. }

• W2016070017 endingPage "12024" @default.
• W2016070017 startingPage "12020" @default.
• W2016070017 abstract "Ribonucleotide reductase (EC 1.17.4.1; RNR), a cell-cycle-regulated enzyme, catalyzes the rate-limiting step in the de novo synthesis of deoxyribonucleotides by the reduction of the corresponding ribonucleotides. The important role of the RNR in DNA synthesis and cell division makes this enzyme an excellent target for chemotherapy. However, nothing is known about this enzyme from the malaria parasite Plasmodium falciparum. We have isolated cDNA clones encoding both the large and small RNR subunits. The sequences of full-length clones of the large and small RNR subunits revealed an open reading frame encoding 806 and 349 amino acids, respectively, and showed significant identity with other RNR sequences in the data base. RNA blot analysis showed that the size of the large and small RNR subunit transcripts are 5.4 kb and 2.2 kb, respectively. Both the RNR subunit transcripts fluctuate in level during the cell cycle, reaching a peak preceding maximal DNA synthesis activity. An oligodeoxynucleotide phosphorothioate that is complementary to sequences around the translational initiation codon of the small RNR subunit showed significant inhibition of growth, as measured by the inhibition in DNA synthesis." @default.
• W2016070017 created "2016-06-24" @default.
• W2016070017 creator A5050852618 @default.
• W2016070017 creator A5063795605 @default.
• W2016070017 creator A5064928599 @default.
• W2016070017 date "1993-12-15" @default.
• W2016070017 modified "2023-10-16" @default.
• W2016070017 title "Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum." @default.
• W2016070017 cites W1521664811 @default.
• W2016070017 cites W1967830103 @default.
• W2016070017 cites W1969503178 @default.
• W2016070017 cites W1972147130 @default.
• W2016070017 cites W1981784972 @default.
• W2016070017 cites W1990807584 @default.
• W2016070017 cites W1996498777 @default.
• W2016070017 cites W2009105413 @default.
• W2016070017 cites W2009310436 @default.
• W2016070017 cites W2013187491 @default.
• W2016070017 cites W2020251171 @default.
• W2016070017 cites W2027073862 @default.
• W2016070017 cites W2029365127 @default.
• W2016070017 cites W2036776952 @default.
• W2016070017 cites W2055043387 @default.
• W2016070017 cites W2092167912 @default.
• W2016070017 cites W2102249603 @default.
• W2016070017 cites W2134812217 @default.
• W2016070017 cites W2138270253 @default.
• W2016070017 cites W2178778111 @default.
• W2016070017 cites W4211183610 @default.
• W2016070017 cites W4231925106 @default.
• W2016070017 doi "https://doi.org/10.1073/pnas.90.24.12020" @default.
• W2016070017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/48117" @default.
• W2016070017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8265664" @default.
• W2016070017 hasPublicationYear "1993" @default.
• W2016070017 type Work @default.
• W2016070017 sameAs 2016070017 @default.
• W2016070017 citedByCount "47" @default.
• W2016070017 countsByYear W20160700172012 @default.
• W2016070017 countsByYear W20160700172013 @default.
• W2016070017 countsByYear W20160700172016 @default.
• W2016070017 countsByYear W20160700172017 @default.
• W2016070017 countsByYear W20160700172018 @default.
• W2016070017 countsByYear W20160700172019 @default.
• W2016070017 countsByYear W20160700172021 @default.
• W2016070017 countsByYear W20160700172022 @default.
• W2016070017 countsByYear W20160700172023 @default.
• W2016070017 crossrefType "journal-article" @default.
• W2016070017 hasAuthorship W2016070017A5050852618 @default.
• W2016070017 hasAuthorship W2016070017A5063795605 @default.
• W2016070017 hasAuthorship W2016070017A5064928599 @default.
• W2016070017 hasBestOaLocation W20160700172 @default.
• W2016070017 hasConcept C104292427 @default.
• W2016070017 hasConcept C104317684 @default.
• W2016070017 hasConcept C153911025 @default.
• W2016070017 hasConcept C167625842 @default.
• W2016070017 hasConcept C187882448 @default.
• W2016070017 hasConcept C203014093 @default.
• W2016070017 hasConcept C2778048844 @default.
• W2016070017 hasConcept C2778371730 @default.
• W2016070017 hasConcept C4710235 @default.
• W2016070017 hasConcept C47289529 @default.
• W2016070017 hasConcept C552990157 @default.
• W2016070017 hasConcept C55493867 @default.
• W2016070017 hasConcept C64241487 @default.
• W2016070017 hasConcept C86803240 @default.
• W2016070017 hasConceptScore W2016070017C104292427 @default.
• W2016070017 hasConceptScore W2016070017C104317684 @default.
• W2016070017 hasConceptScore W2016070017C153911025 @default.
• W2016070017 hasConceptScore W2016070017C167625842 @default.
• W2016070017 hasConceptScore W2016070017C187882448 @default.
• W2016070017 hasConceptScore W2016070017C203014093 @default.
• W2016070017 hasConceptScore W2016070017C2778048844 @default.
• W2016070017 hasConceptScore W2016070017C2778371730 @default.
• W2016070017 hasConceptScore W2016070017C4710235 @default.
• W2016070017 hasConceptScore W2016070017C47289529 @default.
• W2016070017 hasConceptScore W2016070017C552990157 @default.
• W2016070017 hasConceptScore W2016070017C55493867 @default.
• W2016070017 hasConceptScore W2016070017C64241487 @default.
• W2016070017 hasConceptScore W2016070017C86803240 @default.
• W2016070017 hasIssue "24" @default.
• W2016070017 hasLocation W20160700171 @default.
• W2016070017 hasLocation W20160700172 @default.
• W2016070017 hasLocation W20160700173 @default.
• W2016070017 hasLocation W20160700174 @default.
• W2016070017 hasOpenAccess W2016070017 @default.
• W2016070017 hasPrimaryLocation W20160700171 @default.
• W2016070017 hasRelatedWork W1946357342 @default.
• W2016070017 hasRelatedWork W1973806491 @default.
• W2016070017 hasRelatedWork W2061886669 @default.
• W2016070017 hasRelatedWork W2087913780 @default.
• W2016070017 hasRelatedWork W2088063203 @default.
• W2016070017 hasRelatedWork W2135592928 @default.
• W2016070017 hasRelatedWork W2169705930 @default.
• W2016070017 hasRelatedWork W2357569463 @default.
• W2016070017 hasRelatedWork W2385878716 @default.
• W2016070017 hasRelatedWork W386297418 @default.
• W2016070017 hasVolume "90" @default.
• W2016070017 isParatext "false" @default.

• next