FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016070634> ?p ?o ?g. }

• W2016070634 endingPage "146" @default.
• W2016070634 startingPage "141" @default.
• W2016070634 abstract "Acetylsalicylic acid (ASA; aspirin) is one of the most widely used pain reliefs in the world and is certainly effective in the treatment of acute attacks of migraine of moderate severity. It has usually been considered that the action of ASA in migraine is related to peripheral inhibition of mediators of inflammation. Migraine involves episodic head pain that is thought generally to involve intracranial pain structures innervated by the ophthalmic (first) division of the trigeminal nerve, particularly vascular structures that have come to be known as the trigeminovascular system. In this study the effect of ASA on the cerebrovascular effects of the trigeminovascular system were assessed directly with measurements of cerebral blood flow. The trigeminovascular system was activated by stimulation of the superior sagittal sinus (SSS), a midline large venous sinus that is pain sensitive in humans. The SSS was stimulated electrically and cerebral blood flow measured using laser Doppler flowmetry (CBFLDF). Stimulation of the SSS resulted in a stimulus-locked frequency-dependent increase in CBFLDF that reached a mean maximum at 2 Hz with a 60 ± 6% reduction in calculated cerebrovascuiar resistance. Administration of ASA (30 mg/kg i.v.) resulted in a small non-sustained increase in blood pressure but no change in resting CBFLDF. The CBFLDF response to SSS stimulation was reduced at all but one frequency of stimulation to a maximum of a 43 ± 10% reduction in cerebrovascular resistance. Since electrical stimulation involves consecutive depolarization of trigeminovascular axons and bypasses the peripheral nerve vessel interaction it is likely that this effect of ASA is mediated in the central nervous system. Such a possibility draws attention to a possibly novel therapeutic locus of action for ASA and to the importance of central nervous system processing of trigeminovascular inputs that are integral to the clinical expression of migraine." @default.
• W2016070634 created "2016-06-24" @default.
• W2016070634 creator A5004525209 @default.
• W2016070634 creator A5011913237 @default.
• W2016070634 creator A5052319443 @default.
• W2016070634 date "1994-11-01" @default.
• W2016070634 modified "2023-10-17" @default.
• W2016070634 title "Acetylsalicylic acid inhibits cerebral cortical vasodilatation caused by superior sagittal sinus stimulation in the cat*" @default.
• W2016070634 cites W1987191495 @default.
• W2016070634 cites W1994952028 @default.
• W2016070634 cites W1998162142 @default.
• W2016070634 cites W2002698993 @default.
• W2016070634 cites W2007535917 @default.
• W2016070634 cites W2007968941 @default.
• W2016070634 cites W2013756203 @default.
• W2016070634 cites W2014783235 @default.
• W2016070634 cites W2027671989 @default.
• W2016070634 cites W2044558052 @default.
• W2016070634 cites W2046466893 @default.
• W2016070634 cites W2050139294 @default.
• W2016070634 cites W2052850366 @default.
• W2016070634 cites W2061882042 @default.
• W2016070634 cites W2063708538 @default.
• W2016070634 cites W2072984096 @default.
• W2016070634 cites W2074050181 @default.
• W2016070634 cites W2079044122 @default.
• W2016070634 cites W2081272256 @default.
• W2016070634 cites W2083821823 @default.
• W2016070634 cites W2085235556 @default.
• W2016070634 cites W2085595272 @default.
• W2016070634 cites W2087182196 @default.
• W2016070634 cites W2093456877 @default.
• W2016070634 cites W2094032508 @default.
• W2016070634 cites W2108426802 @default.
• W2016070634 cites W2111176046 @default.
• W2016070634 cites W2124142469 @default.
• W2016070634 cites W2128749821 @default.
• W2016070634 cites W2138814983 @default.
• W2016070634 cites W2162090140 @default.
• W2016070634 cites W2169613767 @default.
• W2016070634 cites W2313076091 @default.
• W2016070634 cites W2592900079 @default.
• W2016070634 cites W4239346705 @default.
• W2016070634 doi "https://doi.org/10.1111/j.1468-1331.1994.tb00062.x" @default.
• W2016070634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24283482" @default.
• W2016070634 hasPublicationYear "1994" @default.
• W2016070634 type Work @default.
• W2016070634 sameAs 2016070634 @default.
• W2016070634 citedByCount "10" @default.
• W2016070634 countsByYear W20160706342014 @default.
• W2016070634 countsByYear W20160706342020 @default.
• W2016070634 crossrefType "journal-article" @default.
• W2016070634 hasAuthorship W2016070634A5004525209 @default.
• W2016070634 hasAuthorship W2016070634A5011913237 @default.
• W2016070634 hasAuthorship W2016070634A5052319443 @default.
• W2016070634 hasConcept C120770815 @default.
• W2016070634 hasConcept C126322002 @default.
• W2016070634 hasConcept C148699463 @default.
• W2016070634 hasConcept C15490471 @default.
• W2016070634 hasConcept C157767197 @default.
• W2016070634 hasConcept C164705383 @default.
• W2016070634 hasConcept C170493617 @default.
• W2016070634 hasConcept C24998067 @default.
• W2016070634 hasConcept C2776620988 @default.
• W2016070634 hasConcept C2778541695 @default.
• W2016070634 hasConcept C2780868729 @default.
• W2016070634 hasConcept C42219234 @default.
• W2016070634 hasConcept C71924100 @default.
• W2016070634 hasConceptScore W2016070634C120770815 @default.
• W2016070634 hasConceptScore W2016070634C126322002 @default.
• W2016070634 hasConceptScore W2016070634C148699463 @default.
• W2016070634 hasConceptScore W2016070634C15490471 @default.
• W2016070634 hasConceptScore W2016070634C157767197 @default.
• W2016070634 hasConceptScore W2016070634C164705383 @default.
• W2016070634 hasConceptScore W2016070634C170493617 @default.
• W2016070634 hasConceptScore W2016070634C24998067 @default.
• W2016070634 hasConceptScore W2016070634C2776620988 @default.
• W2016070634 hasConceptScore W2016070634C2778541695 @default.
• W2016070634 hasConceptScore W2016070634C2780868729 @default.
• W2016070634 hasConceptScore W2016070634C42219234 @default.
• W2016070634 hasConceptScore W2016070634C71924100 @default.
• W2016070634 hasIssue "2" @default.
• W2016070634 hasLocation W20160706341 @default.
• W2016070634 hasLocation W20160706342 @default.
• W2016070634 hasOpenAccess W2016070634 @default.
• W2016070634 hasPrimaryLocation W20160706341 @default.
• W2016070634 hasRelatedWork W138243699 @default.
• W2016070634 hasRelatedWork W1964665289 @default.
• W2016070634 hasRelatedWork W1967246491 @default.
• W2016070634 hasRelatedWork W1971103717 @default.
• W2016070634 hasRelatedWork W2352125643 @default.
• W2016070634 hasRelatedWork W2374339866 @default.
• W2016070634 hasRelatedWork W2410756174 @default.
• W2016070634 hasRelatedWork W4251340453 @default.
• W2016070634 hasRelatedWork W856344202 @default.
• W2016070634 hasRelatedWork W182776809 @default.
• W2016070634 hasVolume "1" @default.
• W2016070634 isParatext "false" @default.

• next