FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016073193> ?p ?o ?g. }

• W2016073193 endingPage "S820" @default.
• W2016073193 startingPage "S820" @default.
• W2016073193 abstract "In stereotactic ablative radiation therapy (SABR), high doses per fraction are delivered so that the desired target receives the prescribed dose, with a minimal excess volume and a sharp dose fall-off outside the target volume. The purpose of this study is to evaluate the relationship between the conformity index (CI), the homogeneity index (HI), and the conformity gradient index (CGI) and the development of radiation pneumonitis (RP) in early stage non small cell lung cancer (NSCLC) patients treated with SABR delivered by Helical Tomotherapy (HT). From May 2009 to May 2011, nine consecutive I-IIA stage NSCLC patients with a median age of 75 years (range, 70 to 79) underwent SABR with HT. Patients were treated with 60 Gy at 12 Gy/fraction (n = 7) or 7.5 Gy/fraction (n = 2). Median follow-up time was 16 months (range, 8 to 40). Clinical toxicity was scored using the CTC v3.0. CI was assessed according the RTOG (CIRTOG = [Volume of the reference isodose]/[Target volume]) and Paddick (CIPaddick = [Target volume covered by the reference isodose]/ [Target volume * Volume of the reference isodose]) criteria. HI was evaluated according the RTOG criteria (HIRTOG = [Maximum isodose in the target]/[Reference isodose]). Finally, the CGI was defined as [(Target volume)/(Volume of the reference isodose)]*100. Data were analyzed by using Spearman's correlation test. Median planning target volume (PTV) was 68 cc (range, 41-157). Mean lung dose (MLD) was 6Gy. Median lung volume receiving 5 (V5) and 20 Gy (V20) was 43% and 24%, respectively, for the ipsilateral lung; and 5% and 0.3%, respectively, for the contralateral lung. The average dose conformity and homogeneity index values were 1.25 +/-0.06 and 1.15 +/-0.05, respectively. CGI ranged from 75 to 88 (average 84). A greater PTV was correlated with a better CIPaddick (r = 0.83: P = 0.006) and CIRTOG (r = 0,98; P <0.0001). A better HIRTOG was correlated with a lower total lung V20 (r = 0.78:P = 0.013) and a lower contralateral lung V20 (r = 0.79:P = 0.011). Eight patients experienced RP: 6 had Grade 1 RP and 2 had Grade 2 RP. A higher RP was correlated with a higher contralateral lung V20 (r = 0.79:P = 0.012) or a worse HIRTOG (r = 0.69:P = 0.04). In addition, a higher PTV was marginally correlated with a higher RP (r = 0.62: P = 0.076). Finally, a better CGI was correlated with a higher RP (r = 0.76: P = 0.018). The HI and the CGI correlated with RP in early stage NSCLC patients treated with SABR delivered by HT, the better the HI, the lower the RP Grade; and the better the CGI, the higher the RP Grade. Additionally, a higher contralateral lung V20 was correlated with a higher RP Grade. If validated in a larger population, this information should help to design treatment plans for patients who are at high risk of toxicity." @default.
• W2016073193 created "2016-06-24" @default.
• W2016073193 creator A5002376034 @default.
• W2016073193 creator A5024711322 @default.
• W2016073193 creator A5031823334 @default.
• W2016073193 creator A5049366267 @default.
• W2016073193 creator A5054266059 @default.
• W2016073193 creator A5065061632 @default.
• W2016073193 creator A5076536874 @default.
• W2016073193 creator A5085065870 @default.
• W2016073193 creator A5090466794 @default.
• W2016073193 date "2012-11-01" @default.
• W2016073193 modified "2023-10-05" @default.
• W2016073193 title "Stereotactic Ablative Radiation Therapy Delivered by Helical Tomotherapy for Early-Stage Non-small Cell Lung Cancer: Dosimetric Evaluation and Toxicity" @default.
• W2016073193 doi "https://doi.org/10.1016/j.ijrobp.2012.07.2194" @default.
• W2016073193 hasPublicationYear "2012" @default.
• W2016073193 type Work @default.
• W2016073193 sameAs 2016073193 @default.
• W2016073193 citedByCount "1" @default.
• W2016073193 countsByYear W20160731932017 @default.
• W2016073193 crossrefType "journal-article" @default.
• W2016073193 hasAuthorship W2016073193A5002376034 @default.
• W2016073193 hasAuthorship W2016073193A5024711322 @default.
• W2016073193 hasAuthorship W2016073193A5031823334 @default.
• W2016073193 hasAuthorship W2016073193A5049366267 @default.
• W2016073193 hasAuthorship W2016073193A5054266059 @default.
• W2016073193 hasAuthorship W2016073193A5065061632 @default.
• W2016073193 hasAuthorship W2016073193A5076536874 @default.
• W2016073193 hasAuthorship W2016073193A5085065870 @default.
• W2016073193 hasAuthorship W2016073193A5090466794 @default.
• W2016073193 hasBestOaLocation W20160731931 @default.
• W2016073193 hasConcept C106159729 @default.
• W2016073193 hasConcept C126322002 @default.
• W2016073193 hasConcept C126838900 @default.
• W2016073193 hasConcept C146357865 @default.
• W2016073193 hasConcept C151730666 @default.
• W2016073193 hasConcept C162324750 @default.
• W2016073193 hasConcept C187625094 @default.
• W2016073193 hasConcept C19617505 @default.
• W2016073193 hasConcept C27101514 @default.
• W2016073193 hasConcept C2776256026 @default.
• W2016073193 hasConcept C2776713427 @default.
• W2016073193 hasConcept C2777714996 @default.
• W2016073193 hasConcept C2780387249 @default.
• W2016073193 hasConcept C2989005 @default.
• W2016073193 hasConcept C509974204 @default.
• W2016073193 hasConcept C71924100 @default.
• W2016073193 hasConcept C85393063 @default.
• W2016073193 hasConcept C86803240 @default.
• W2016073193 hasConcept C91602232 @default.
• W2016073193 hasConceptScore W2016073193C106159729 @default.
• W2016073193 hasConceptScore W2016073193C126322002 @default.
• W2016073193 hasConceptScore W2016073193C126838900 @default.
• W2016073193 hasConceptScore W2016073193C146357865 @default.
• W2016073193 hasConceptScore W2016073193C151730666 @default.
• W2016073193 hasConceptScore W2016073193C162324750 @default.
• W2016073193 hasConceptScore W2016073193C187625094 @default.
• W2016073193 hasConceptScore W2016073193C19617505 @default.
• W2016073193 hasConceptScore W2016073193C27101514 @default.
• W2016073193 hasConceptScore W2016073193C2776256026 @default.
• W2016073193 hasConceptScore W2016073193C2776713427 @default.
• W2016073193 hasConceptScore W2016073193C2777714996 @default.
• W2016073193 hasConceptScore W2016073193C2780387249 @default.
• W2016073193 hasConceptScore W2016073193C2989005 @default.
• W2016073193 hasConceptScore W2016073193C509974204 @default.
• W2016073193 hasConceptScore W2016073193C71924100 @default.
• W2016073193 hasConceptScore W2016073193C85393063 @default.
• W2016073193 hasConceptScore W2016073193C86803240 @default.
• W2016073193 hasConceptScore W2016073193C91602232 @default.
• W2016073193 hasIssue "3" @default.
• W2016073193 hasLocation W20160731931 @default.
• W2016073193 hasOpenAccess W2016073193 @default.
• W2016073193 hasPrimaryLocation W20160731931 @default.
• W2016073193 hasRelatedWork W1999715968 @default.
• W2016073193 hasRelatedWork W2016073193 @default.
• W2016073193 hasRelatedWork W2040306711 @default.
• W2016073193 hasRelatedWork W2081086746 @default.
• W2016073193 hasRelatedWork W2337379543 @default.
• W2016073193 hasRelatedWork W2468978631 @default.
• W2016073193 hasRelatedWork W2559911131 @default.
• W2016073193 hasRelatedWork W2604581058 @default.
• W2016073193 hasRelatedWork W3210566707 @default.
• W2016073193 hasRelatedWork W4385225528 @default.
• W2016073193 hasVolume "84" @default.
• W2016073193 isParatext "false" @default.
• W2016073193 isRetracted "false" @default.
• W2016073193 magId "2016073193" @default.
• W2016073193 workType "article" @default.