FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016074405> ?p ?o ?g. }

• W2016074405 endingPage "e52" @default.
• W2016074405 startingPage "e52" @default.
• W2016074405 abstract "<b>Background:</b> Compound heterozygotes of the haemochromatosis gene (<i>HFE</i>) variants, H63D and C282Y, have raised transferrin saturation compared with that in the wild type. In the cohort of the Oxford Project To Investigate Memory and Ageing (OPTIMA), bicarriers of the <i>HFE</i> C282Y and the transferrin C2 gene variants are at five times greater risk of developing Alzheimer’s disease; the addition of <i>HFE</i> H63D may raise the risk still further. <b>Objective:</b> To investigate transferrin saturation by <i>HFE</i> and transferrin genotype among people without dementia–that is, controls and those with mild cognitive impairment (MCI)—and also among those with Alzheimer’s disease. <b>Methods:</b> Serum iron status and genotype were examined of 177 patients with Alzheimer’s disease, 69 patients with MCI and 197 controls from the OPTIMA cohort. <b>Results:</b> Although each of these variants alone had relatively little effect on iron status, the combination of either <i>HFE</i> C282Y and <i>HFE</i> H63D or of <i>HFE</i> C282Y and transferrin C2 markedly raised transferrin saturation in those without dementia, but had little effect in those with mature Alzheimer’s disease. <b>Conclusions:</b> These combinations may raise the risk for Alzheimer’s disease, owing to higher iron loads and therefore oxidative stress in the preclinical phase. If replicated, these findings will have implications for the prevention of Alzheimer’s disease." @default.
• W2016074405 created "2016-06-24" @default.
• W2016074405 creator A5030330229 @default.
• W2016074405 creator A5031025531 @default.
• W2016074405 creator A5043275257 @default.
• W2016074405 creator A5063798423 @default.
• W2016074405 creator A5067159657 @default.
• W2016074405 creator A5072087469 @default.
• W2016074405 creator A5073029717 @default.
• W2016074405 creator A5078698655 @default.
• W2016074405 date "2006-03-29" @default.
• W2016074405 modified "2023-09-26" @default.
• W2016074405 title "Iron genes, iron load and risk of Alzheimer's disease" @default.
• W2016074405 cites W1542215809 @default.
• W2016074405 cites W1968144312 @default.
• W2016074405 cites W1975788427 @default.
• W2016074405 cites W1977738320 @default.
• W2016074405 cites W1985859760 @default.
• W2016074405 cites W1985985118 @default.
• W2016074405 cites W1989237980 @default.
• W2016074405 cites W1990663225 @default.
• W2016074405 cites W2010527441 @default.
• W2016074405 cites W2024183011 @default.
• W2016074405 cites W2034897558 @default.
• W2016074405 cites W2038944724 @default.
• W2016074405 cites W2054401837 @default.
• W2016074405 cites W2112587738 @default.
• W2016074405 cites W2114766252 @default.
• W2016074405 cites W2122522567 @default.
• W2016074405 cites W2141937988 @default.
• W2016074405 cites W2146501109 @default.
• W2016074405 cites W2146729934 @default.
• W2016074405 cites W2152907424 @default.
• W2016074405 cites W2156220037 @default.
• W2016074405 cites W2159122349 @default.
• W2016074405 cites W2160400039 @default.
• W2016074405 cites W220834664 @default.
• W2016074405 doi "https://doi.org/10.1136/jmg.2006.040519" @default.
• W2016074405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2563163" @default.
• W2016074405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17047092" @default.
• W2016074405 hasPublicationYear "2006" @default.
• W2016074405 type Work @default.
• W2016074405 sameAs 2016074405 @default.
• W2016074405 citedByCount "47" @default.
• W2016074405 countsByYear W20160744052012 @default.
• W2016074405 countsByYear W20160744052013 @default.
• W2016074405 countsByYear W20160744052014 @default.
• W2016074405 countsByYear W20160744052015 @default.
• W2016074405 countsByYear W20160744052016 @default.
• W2016074405 countsByYear W20160744052018 @default.
• W2016074405 countsByYear W20160744052019 @default.
• W2016074405 countsByYear W20160744052020 @default.
• W2016074405 countsByYear W20160744052022 @default.
• W2016074405 countsByYear W20160744052023 @default.
• W2016074405 crossrefType "journal-article" @default.
• W2016074405 hasAuthorship W2016074405A5030330229 @default.
• W2016074405 hasAuthorship W2016074405A5031025531 @default.
• W2016074405 hasAuthorship W2016074405A5043275257 @default.
• W2016074405 hasAuthorship W2016074405A5063798423 @default.
• W2016074405 hasAuthorship W2016074405A5067159657 @default.
• W2016074405 hasAuthorship W2016074405A5072087469 @default.
• W2016074405 hasAuthorship W2016074405A5073029717 @default.
• W2016074405 hasAuthorship W2016074405A5078698655 @default.
• W2016074405 hasBestOaLocation W20160744052 @default.
• W2016074405 hasConcept C104317684 @default.
• W2016074405 hasConcept C126322002 @default.
• W2016074405 hasConcept C135763542 @default.
• W2016074405 hasConcept C153852466 @default.
• W2016074405 hasConcept C22814914 @default.
• W2016074405 hasConcept C2776590208 @default.
• W2016074405 hasConcept C2778248108 @default.
• W2016074405 hasConcept C2778319317 @default.
• W2016074405 hasConcept C2779134260 @default.
• W2016074405 hasConcept C2779483572 @default.
• W2016074405 hasConcept C2779875672 @default.
• W2016074405 hasConcept C3019184707 @default.
• W2016074405 hasConcept C502032728 @default.
• W2016074405 hasConcept C54355233 @default.
• W2016074405 hasConcept C71924100 @default.
• W2016074405 hasConcept C72563966 @default.
• W2016074405 hasConcept C86803240 @default.
• W2016074405 hasConceptScore W2016074405C104317684 @default.
• W2016074405 hasConceptScore W2016074405C126322002 @default.
• W2016074405 hasConceptScore W2016074405C135763542 @default.
• W2016074405 hasConceptScore W2016074405C153852466 @default.
• W2016074405 hasConceptScore W2016074405C22814914 @default.
• W2016074405 hasConceptScore W2016074405C2776590208 @default.
• W2016074405 hasConceptScore W2016074405C2778248108 @default.
• W2016074405 hasConceptScore W2016074405C2778319317 @default.
• W2016074405 hasConceptScore W2016074405C2779134260 @default.
• W2016074405 hasConceptScore W2016074405C2779483572 @default.
• W2016074405 hasConceptScore W2016074405C2779875672 @default.
• W2016074405 hasConceptScore W2016074405C3019184707 @default.
• W2016074405 hasConceptScore W2016074405C502032728 @default.
• W2016074405 hasConceptScore W2016074405C54355233 @default.
• W2016074405 hasConceptScore W2016074405C71924100 @default.
• W2016074405 hasConceptScore W2016074405C72563966 @default.
• W2016074405 hasConceptScore W2016074405C86803240 @default.

• next